Pathogenesis of swine vesicular disease after exposure of pigs to an infected environment

Dekker, A.; Moonen, P.L.J.M.; Boer-Luijtze, Els A. de; Terpstra, C.

doi:10.1016/0378-1135(95)00032-6

Cited by 35 publications

(33 citation statements)

References 6 publications

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“…As the clinical signs resemble those of foot-and-mouth disease, SVD is classified as an OIE list A disease. The skin is considered the main entry site of the virus [2][3][4]. Inoculation on that predilection site, however, even with high doses, does not always produce clinical signs in all inoculated pigs [2].…”

Section: Introductionmentioning

confidence: 99%

Isotype specific ELISAs to detect antibodies against swine vesicular disease virus and their use in epidemiology

Dekker¹,

Hemert-Kluitenberg²,

Baars³

et al. 2002

Epidemiol. Infect.

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Isotype specific ELISAs to detect antibodies against swine vesicular disease, which may help to estimate the moment of infection, were developed and validated on sera from pigs experimentally infected with four different isolates of swine vesicular disease virus. Virus specific IgM antibodies could be detected from days 3–49 and occasionally up to day 91 after infection. IgG1 antibodies were first detected at day 8 and IgG2 at day 11. IgA antibodies coincided with IgG1 antibodies, but antibody titres varied widely. From the results obtained with the sera from the experimentally infected pigs, we calculated the day at which 50% of the pigs had become positive (D50). A D50 of 5, 4, 12, 12 and 24 days was calculated, respectively, for the appearance of antibodies in the virus neutralization test, the IgM, total IgG, IgG1 and IgG2 ELISA. A D50 of 49 days was calculated for the disappearance of IgM antibodies. The isotype specific ELISAs proved to be valuable tools to study the epidemiology of the disease.

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Section: Introductionmentioning

confidence: 99%

Isotype specific ELISAs to detect antibodies against swine vesicular disease virus and their use in epidemiology

Dekker¹,

Hemert-Kluitenberg²,

Baars³

et al. 2002

Epidemiol. Infect.

Self Cite

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“…Experimental SVDV infection can lead to clinical signs within 2 days and SVDV has been isolated from a wide range of tissues (6,10,14,33).…”

Section: Pathogenesismentioning

confidence: 99%

“…For this reason, it was suggested that the pigs may have become infected at the slaughterhouse (Terpstra, personal communication). This finding led to experiments which showed that, after contact of a pig with a SVDV-contaminated environment, viraemia can develop within 1 day, which is equal to the time needed when pigs are directly inoculated (Table 1) (14). Table 1 also shows that virus can be isolated from various lymph nodes, probably due to drainage of sites where the virus replicates.…”

Section: Pathogenesismentioning

confidence: 99%

“…SVDV has a strong tropism for epithelial tissues but virus titres in the myocardium and the brain significantly exceed those in plasma. So, epithelial tissues, myocardium, and brain are probably the sites of virus replication (10,14,33). Lymph nodes also may contain high titres of SVDV after experimental infection.…”

Section: Pathogenesismentioning

confidence: 99%

“…The exceptionally high stability of the virus outside the host is the reason why indirect contacts like transport vehicles or waste food play an essential role in the epizootiology of SVD. Dekker et al (14) showed that contact with a contaminated environment can lead to viraemia in 1 day and clinical signs within 2 days. Studies on SVDV transmission within an outbreak farm showed that spread from one pen to probably occurs when there is a shared open drainage system or frequent movement of pigs between pens.…”

Section: Epizootiologymentioning

confidence: 99%

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