Pathogenesis of rheumatoid arthritis and its treatment with anti-inflammatory natural products

Sharma, Ayushi; Goel, Anjana

doi:10.1007/s11033-023-08406-4

Cited by 16 publications

(11 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The past 5 years have seen the identification of novel biomarkers, particularly genomics, which are the fields that follow from the study of proteins (proteomics) and metabolites (metabolomics). When treating patients with RA, these indicators help the doctor choose the best course of action [ 56 ].…”

Section: Clinical Biomarkers and Diagnosis Of Ramentioning

confidence: 99%

See 1 more Smart Citation

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

Atta,

Salem,

El-Said

et al. 2024

Cell Mol Biol Lett

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration and worsening symptoms. Adenosine deaminase (ADA), an enzyme in purine metabolism, influences adenosine levels and joint inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases in hypoxic and inflammatory conditions. Lymphocytes with ADA play a role in RA. Inhibiting lymphocytic ADA activity has an immune-regulatory effect. Synovial fluid levels of ADA are closely associated with the disease’s systemic activity, making it a useful parameter for evaluating joint inflammation. Flavonoids, such as quercetin (QUE), are natural substances that can inhibit ADA activity. QUE demonstrates immune-regulatory effects and restores T-cell homeostasis, making it a promising candidate for RA therapy. In this review, we will explore the impact of QUE in suppressing ADA and reducing produced the inflammation in RA, including preclinical investigations and clinical trials. Graphical Abstract

show abstract

Section: Clinical Biomarkers and Diagnosis Of Ramentioning

confidence: 99%

“…The circulating mononuclear cells from patients with RA had far lower levels of ADA than cells from healthy individuals. On the other hand, the synovial effusions of those with RA contained high quantities of this enzyme activity [ 56 ].…”

Section: Adenosine Deaminase (Ada) a Key Inflammatory Enzymementioning

confidence: 99%

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

Atta,

Salem,

El-Said

et al. 2024

Cell Mol Biol Lett

View full text Add to dashboard Cite

show abstract

“…Other symptoms may be present, and additional organs may also be affected. This is a common disorder with a prevalence of 0.5-1.0% [71,72]. Females are 2-3 times more prone to RA than males [72].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

“…This is a common disorder with a prevalence of 0.5-1.0% [71,72]. Females are 2-3 times more prone to RA than males [72]. It is believed that the pain in RA is initiated by local inflammation, and that after the inflammation subsides, the main mechanism underlying the pain resides in the CNS in the form of central sensitization.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Satellite Glial Cells in Human Disease

Hanani

2024

Cells

View full text Add to dashboard Cite

Satellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suffering from common painful diseases, such as rheumatoid arthritis and fibromyalgia, may contribute to the pain phenotype. It was found that immunoglobulins G (IgG) from fibromyalgia patients can induce pain-like behavior in mice. Moreover, these IgGs bind preferentially to SGCs and activate them, which can sensitize the sensory neurons, causing nociception. In other human diseases, the evidence is not as direct as in fibromyalgia, but it has been found that an antibody from a patient with rheumatoid arthritis binds to mouse SGCs, which leads to the release of pronociceptive factors from them. Herpes zoster is another painful disease, and it appears that the zoster virus resides in SGCs, which acquire an abnormal morphology and may participate in the infection and pain generation. More work needs to be undertaken on SGCs in humans, and this review points to several promising avenues for better understanding disease mechanisms and developing effective pain therapies.

show abstract

“…Herbal therapies have been used conveniently for some time with no obvious toxicity or adverse effects, prompting a fresh wave of research into conventional methods currently. Sharma and Goel (2023) suggest that now is the time to look for new and improved natural medicines that can be used for the long-term treatment of RA.…”

Section: Introductionmentioning

confidence: 99%

Analysis of anti-rheumatic activity of Nyctanthes arbor-tristis via in vivo and pharmacovigilance approaches

Sharma,

Goel,

Lin

2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Introduction: Rheumatoid arthritis (RA) is an immune-mediated disease associated with chronic inflammation of numerous joints. Nyctanthes arbor-tristis (NAT) is a traditional remedy for RA, a chronic inflammatory disorder.Aim: The current project aims to demonstrate the role of the NAT extracts in sub-acute toxicity, pharmacovigilance, and anti-rheumatic biomarkers.Method: Hydroethanolic extract (1:1) of plant leaves was prepared by using the reflux method. The safety of the dose was evaluated in Sprague–Dawley rats, and the anti-inflammatory effects of NAT on RA symptoms, including paw volumes, body weight, arthritic index, withdrawal latency, hematology and serological test, radiology, and histopathology, were evaluated in Freund’s complete adjuvant (FCA)-induced arthritis Sprague–Dawley rat models. The inflammatory (TNF-α and COX-2) and anti-inflammatory markers (IL-10) were analyzed in control and experimental groups.Result: The study showed that 500 mg/kg BW NAT leaf extract was found to be least toxic without showing any subacute toxicity symptoms. The pharmacovigilance study highlighted the potential side effects of NAT, such as drowsiness, sedation, and lethargy, at high dosages. Treatment with the plant extract mitigated paw edema, restored the immune organ and body weights, and ameliorated the level of blood parameters such as hemoglobin, red blood cells, platelets, white blood cells, aspartate aminotransferase (AST), alanine transaminase (ALT), C-reactive proteins, and rheumatoid factor. Treatment with the plant extracts also reduced the level of cyclooxygenase 2 and TNF-α and increased the level of IL-10 in the serum of arthritic rats dose-dependently. Radiographic analysis of the ankle joint showed an improvement in the hind legs. Histological examination of the ankle joints revealed that the plant extract treatment decreased pannus formation, inflammation, and synovial hyperplasia in arthritic animals.Conclusion: NAT 500 mg/kg could serve as a promising therapeutic option for the treatment of inflammatory arthritis.

show abstract

Pathogenesis of rheumatoid arthritis and its treatment with anti-inflammatory natural products

Cited by 16 publications

References 92 publications

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review

Satellite Glial Cells in Human Disease

Analysis of anti-rheumatic activity of Nyctanthes arbor-tristis via in vivo and pharmacovigilance approaches

Contact Info

Product

Resources

About