Pathogenesis of Primary Acquired Nasolacrimal Duct Obstruction

Kashkouli, Mohsen Bahmani; Sadeghipour, Alireza; Kaghazkanani, Reza; Bayat, Azar; Pakdel, Farzad; Aghai, Gholam Hosseyn

doi:10.3109/01676830903207828

Cited by 45 publications

(27 citation statements)

References 18 publications

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“…A non-specific chronic inflammation with fibrosis is the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens obtained during DCR [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. However, many other pathological processes (of special importance are those with malignant biological behavior) may arise in the lacrimal sac and masquerade as chronic inflammation with clinical symptoms and signs of presumed primary chronic dacryocystitis [1,3,.…”

Section: Introductionmentioning

confidence: 99%

A 7-year prospective study of routine histopathological evaluation of the lacrimal sac wall incisional biopsy specimens obtained during external dacryocystorhinostomy in adults and a review of the literature

Knežević¹,

Stojković²,

Jovanović³

et al. 2011

Med Oncol

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The most common lacrimal sac pathology is chronic inflammation with or without occlusive fibrosis. However, a substantial number of lacrimal sac-specific pathologies were reported throughout the literature which may mimic chronic inflammation and be misdiagnosed. From a tertiary ophthalmic care centre in Serbia, in a single ophthalmic pathology laboratory, during a 7-year period (January 2004 to October 2010), a 599 consecutive lacrimal sac wall biopsy samples routinely obtained during external dacryocystorhinostomy in adult patients with clinically presumed primary acquired lacrimal drainage system obstruction were analysed. Although non-specific lacrimal sac pathology was present in the vast majority of cases (578 biopsy specimens; 96.49%), this report also reveals a relatively substantial number (21 biopsy specimens; 3.51%) of clinically non-suspected or intraoperatively unexpected primary lacrimal sac-specific pathology--among them, six lesions with malignant biological behaviour were identified: one microinvasive squamous cell carcinoma and five malignant lymhoproliferative lesions. Usefulness of routine lacrimal sac wall biopsy during surgery for primary acquired lacrimal drainage system obstruction is undoubtful and commensurate with the constant need for better understanding of the pathological processes that involve lacrimal drainage system.

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Section: Introductionmentioning

confidence: 99%

A 7-year prospective study of routine histopathological evaluation of the lacrimal sac wall incisional biopsy specimens obtained during external dacryocystorhinostomy in adults and a review of the literature

Knežević¹,

Stojković²,

Jovanović³

et al. 2011

Med Oncol

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show abstract

“…Idiopathic chronic inflammation, with or without fibrosis, occurs in clinically presumed primary acquired nasolacrimal duct obstruction (PANDO) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. A wide variety of causes, such as specific inflammatory [9][10][11][12][13], traumatic, mechanical, or neoplastic [14][15][16][17][18] may mimic idiopathic inflammation [19][20][21] in secondary acquired lacrimal drainage system obstruction (SALDO). Neoplastic causes are of special clinical interest ( Figure 1) [22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature

Koturović

Knežević

Rašić

2016

Bosn J of Basic Med Sci

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The main purpose of this paper is to provide the information about the incidence and types of pathology of secondary acquired obstructions of the lacrimal excretory outflow system caused by primary lacrimal sac non-neoplastic and neoplastic lesions. After a thorough literature search, 17 case-control studies were found and selected, data were extracted and categorized, to evaluate specific lacrimal sac pathology mimicking inflammation. A total of 3865 histopathologically examined lacrimal sac wall biopsy specimens from 3662 patients, taken during dacryocystorhinostomy for clinically presumed primary chronic dacryocystitis, were analyzed. The most common reported histopathological finding was non-specific chronic inflammation with or without fibrosis (94.15% of cases). Lacrimal sac-specific pathologies were present in 226 (5.85%) cases. Unsuspected lacrimal sac-specific pathologies were present in 55/226 (24.34%) cases. Almost 45% of primary lacrimal sac malignant neoplasms were not suspected, preoperatively and intraoperatively. Tumor-like lesions of the lacrimal sac were the most common pathology found: (1) lacrimal stones-dacryoliths, (2) pyogenic granuloma, (3) granulation tissues, (4) reactive lymphoid hyperplasia, and (5) lacrimal sac-specific inflammation (Wegener's granulomatosis and sarcoidosis). Neoplastic pathology was found in 55/3865 (1.42%) lacrimal sac wall biopsy specimens; of those, malignant cases were 2.24 times more frequent than benign. Lymphoma was the most common preoperatively unsuspected or intraoperatively unexpected neoplastic pathology. This analysis of the relevant literature highlights the value of routine lacrimal sac biopsy during surgery for clinically presumed primary acquired nasolacrimal duct obstruction.

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“…It affects women, typically after age 40, more frequently than men (Woog, 2007). Studies have shown the higher incidence of NLDO in women is not related to sexual hormones, viral infection, or eye make-up (Kashkouli et al, 2010). The increased incidence is believed to be related to the anatomical difference between the bony nasolacrimal excretory system in men versus women (Groessl et al, 1997).…”

mentioning

confidence: 98%

Facial Asymmetry and Nasal Septal Deviation in Acquired Nasolacrimal Duct Obstruction

Taban

Jarullazada

Mancini

et al. 2011

Orbit

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Pathogenesis of Primary Acquired Nasolacrimal Duct Obstruction

Abstract: This study did not find any evidence in favor of the role of viral infection (HSV1, HSV2, HPV), eye make-up, and sex hormones in pathogenesis of PANDO. No abnormal pathology was found in lacrimal sac biopsy of patients with PANDO.

Cited by 45 publications

References 18 publications

A 7-year prospective study of routine histopathological evaluation of the lacrimal sac wall incisional biopsy specimens obtained during external dacryocystorhinostomy in adults and a review of the literature

A 7-year prospective study of routine histopathological evaluation of the lacrimal sac wall incisional biopsy specimens obtained during external dacryocystorhinostomy in adults and a review of the literature

Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature

Facial Asymmetry and Nasal Septal Deviation in Acquired Nasolacrimal Duct Obstruction

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