Pathogenesis of Post-Traumatic Stress Disorder and Therapeutic Targets

Lapshin, M. S.; Kondashevskaya, M. V.; Epishev, V. V.; Patochkina, N. A.

doi:10.1007/s11055-023-01501-w

Cited by 2 publications

(1 citation statement)

References 71 publications

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“…This same study found alterations in stress hormones in connection to both violence exposure and psychological distress [assessed by Diagnostic Interview Schedule for Children, Version IV, ( 54 )]. Alterations in cortisol levels have also been associated with elevated risks of anxiety, depression, and PTSD [e.g., ( 55 )]. The combination of the absence of relevant neurobiological findings regarding violence exposure and psychological distress in adults in the body of literature and our findings that there are no gender-based differences in the relation between violence exposure and psychological distress among a cohort of highly exposed middle-aged individuals could suggest that as individuals age, gendered differences in the violence-distress interplay decrease.…”

Section: Discussionmentioning

confidence: 99%

The link between exposure to violence and psychological distress among middle-aged Muslims in Israel: the role of gender

Iktilat,

Isacson,

Tzemah-Shahar

et al. 2024

Front. Public Health

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IntroductionTo date, it is still unclear if exposure to violence affects psychological distress in middle-aged adults and if the effects are gender specific. This age group is of special interest as it is at the onset of the aging process and is often overlooked or understudied in scholarly research. Specifically, targeted research on middle-aged Muslims living in Israel, a unique population exposed to increasing violence, is lacking.MethodsWe examined the relationship between exposure to violence and psychological distress in a cohort of 363 middle-aged adults (223 women) from three Muslim villages in northern Israel, collecting data on violence exposure (Screen for Adolescent Violence Exposure (SAVE) questionnaire), psychological distress (Kessler 6 Psychological Distress questionnaire), and other demographic characteristics including education level and socioeconomic status. We used this data to answer two questions: (1) is exposure to violence a predictor of psychological distress in middle-aged Muslims, and (2) does the relationship between exposure and distress differ between men and women?ResultsWe revealed a positive link between exposure to violence and psychological distress (β = 0.145, p = 0.017) when controlling for gender, age, education level, and socioeconomic level.DiscussionDespite previous evidence of gender-based differences in this interplay in younger cohorts, we did not find a significant interaction between gender and the violence exposure-psychological distress interplay. Our findings are some of the first to focus on middle-aged individuals and show that both men and women exhibit connections between exposure to violence and psychological distress when considering covariates. This research provides insights that can be used when planning community-wide interventions and treatment schemes to support healthy aging.

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Section: Discussionmentioning

confidence: 99%

The link between exposure to violence and psychological distress among middle-aged Muslims in Israel: the role of gender

Iktilat,

Isacson,

Tzemah-Shahar

et al. 2024

Front. Public Health

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The Synergistic Trio of Metabolic Master Regulators Sustaining a Vicious Circle of Pathological Processes in Post-Traumatic Stress Disorder

Kondashevskaya,

Artemyeva,

Mikhaleva

2024

J Evol Biochem Phys

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Post-traumatic stress disorder (PTSD) is a maladaptive response to the exposure of an extraordinary-intensity stressor. The animal and human body responds to any external challenges at the systemic, organismal and cellular levels. In stress-sensitive individuals, the collaboration of stress-implementing and stress-limiting systems is compromised, causing the transformation of behavior, cognitive abilities and other functions of the central nervous system. It is commonly accepted now that changes in the abundance and repertoire of the intestinal microbiota play an important role in the pathogenesis of PTSD. In this regard, the methods of improving the microflora are high on the agenda. Analyzing the literature data, we came to the conclusion that metabolic, somatic and mental health largely depends on the coordinated functioning of the key interdependent metabolic components: hepatobiliary system, intestinal microbiota and, as we believe, the state of mast cells. Close scrutiny of the interplay of these components will help identify new therapeutic targets and the most effective methods to treat PTSD.

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Pathogenesis of Post-Traumatic Stress Disorder and Therapeutic Targets

Cited by 2 publications

References 71 publications

The link between exposure to violence and psychological distress among middle-aged Muslims in Israel: the role of gender

The link between exposure to violence and psychological distress among middle-aged Muslims in Israel: the role of gender

The Synergistic Trio of Metabolic Master Regulators Sustaining a Vicious Circle of Pathological Processes in Post-Traumatic Stress Disorder

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