Pathogenesis of pancreatic fibrosis in chronic alcoholic pancreatitis

Tanaka, Takuo; Fujii, Tsutomu; Matsugu, Yasuhiro; Kodoh, Y.; Koide, Kei; Miura, Yoshifumi; Ichiba, Yasuyuki; Dohi, Kiyohiko

doi:10.1016/s0016-5085(98)82039-8

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ansa pancreatica is widely assumed to be a predisposing factor for pancreatitis, particularly in heavy alcohol consumers[24-26]. Indeed, we found that the frequency of ansa pancreatica was highest in patients with alcoholic pancreatitis, although this was not statistically significant.…”

Section: Discussioncontrasting

confidence: 62%

Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis

Hayashi¹,

Gonoi²,

Yoshikawa³

et al. 2016

WJG

View full text Add to dashboard Cite

AIMTo determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging (MRI).METHODSOur institutional review board approved this cross-sectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis (55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis). All of the subjects underwent abdominal MRI including magnetic resonance cholangiopancreatography, medical examinations, and blood tests. Two board-certified, diagnostic, abdominal radiologists evaluated the images, and ansa pancreatica was diagnosed based on its characteristic anatomy on MRI.RESULTSCompared with the community group [5/587 (0.85%)], patients with recurrent acute pancreatitis had a significantly higher frequency of ansa pancreatica [2/18 (11.1%)] (P = 0.016; OR = 14.3; 95%CI: 1.27-96.1), but not compared with patients with single-episode acute pancreatitis [1/55 (1.8%)] (P = 0.42; OR = 2.1; 95%CI: 0.44-19.7). Multiple logistic regression analysis using age, alcohol intake, presence of ansa pancreatica, and presence of autoimmune disease as independent covariates, revealed a significant relationship between the presence of ansa pancreatica and recurrent acute pancreatitis. The presence of autoimmune disease was also significantly associated with the onset of recurrent acute pancreatitis. On the other hand, neither age nor alcohol intake were significantly related to the onset of recurrent acute pancreatitis.CONCLUSIONThe present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis.

show abstract

Section: Discussioncontrasting

confidence: 62%

Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis

Hayashi¹,

Gonoi²,

Yoshikawa³

et al. 2016

WJG

View full text Add to dashboard Cite

show abstract

“…Less common configurations include a rudimentary duct of Santorini (30% of cases), a dominant duct of Santorini (1%), and "ansa pancreatica," in which the duct of Santorini forms a sigmoid curve as it courses to the duct of Wirsung (Fig 6) (9). Narrowing of the caliber of the duct at the "knee" of the MPD can be seen, a finding that represents the site of fusion of the dorsal and ventral ducts.…”

Section: Anatomic Variants Pancreasmentioning

confidence: 99%

Multimodality Imaging of Pancreatic and Biliary Congenital Anomalies

Mortelé¹,

Rocha²,

Streeter³

et al. 2006

RadioGraphics

277

174

View full text Add to dashboard Cite

A wide spectrum of anomalies of the pancreas, the pancreatic ductal system, and the biliary tree are commonly encountered at radiologic evaluation. These anomalies may simulate various neoplastic, inflammatory, and posttraumatic conditions and should be part of the differential diagnosis for a variety of abnormalities found at diagnostic imaging. Anatomic variants, developmental anomalies (eg, pancreas divisum, annular pancreas, ectopic pancreas, pancreatic agenesis and hypoplasia), and congenital diseases (congenital pancreatic cysts, von Hippel-Lindau disease, choledochal cysts), in addition to potential imaging pitfalls (uneven distribution of fat, "pseudomasses"), can all pose a diagnostic challenge for the radiologist. Familiarity with these anomalies, the imaging techniques available for their study, and their variable imaging manifestations is necessary for differentiating them from other biliary and pancreatic conditions. A basic understanding of the embryologic development and normal anatomy of the pancreas and biliary tree is also essential for identifying these anomalies.

show abstract

“…Calcium carbonate is deposited over the nidus through multiple layers and stages [ 13 ]. In cases of chronic pancreatitis associated with alcohol, there is decreased pancreatic stone protein secretion which results in the crystallization of calcium carbonate and its deposition leading to stone formation [ 14 ]. Pancreatic duct strictures result in pancreatic juice stagnation and promote the development of pancreatic stones.…”

Section: Reviewmentioning

confidence: 99%

Management of Pancreatic Calculi in Chronic Pancreatitis: A Review Article

Kaushik¹,

Dasari²,

Jain³

2023

Cureus

View full text Add to dashboard Cite

Chronic pancreatitis is a slow, irreversible, and progressive inflammatory condition with abdominal pain, loss of parenchyma, fibrosis, and calculus formation. It also causes loss of exocrine and endocrine function. Gallstones and alcohol is the most frequent cause of chronic pancreatitis. It is also caused by other factors, including oxidative stress, fibrosis, and repeated incidence of acute pancreatitis. Chronic pancreatitis is followed by several sequelae, one of them being formation of calculi in the pancreas. The formation of calculi can occur in the main pancreatic duct, branches of the duct, and parenchyma. The cardinal sign of chronic pancreatitis is pain caused by obstruction of pancreatic ducts and its branches leading to ductal hypertension resulting in pain. The main aim of endotherapy includes pancreatic duct decompression. The management options vary based on the type and size of the calculus. The treatment of choice for small-sized pancreatic calculi is endoscopic retrograde cholangiopancreatography (ERCP) followed by sphincterotomy and extraction. The large-sized calculi need fragmentation before extraction, which is done by extracorporeal shock wave lithotripsy (ESWL). Surgery can be an option for patients having severe pancreatic calculi if endoscopic therapy fails. For diagnostic purposes, imaging plays a very important role. The treatment options remain complex if the radiological and laboratory findings overlap. Due to advancements in diagnostic imaging, treatment options have become precise and helpful. It can significantly lower the quality of life along with immediate and long-term problems that pose a serious risk to life. This review comprises the various management options available for removing calculi following chronic pancreatitis, including surgical, endoscopic, and medical therapy.

show abstract

Pathogenesis of pancreatic fibrosis in chronic alcoholic pancreatitis

Cited by 4 publications

References 0 publications

Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis

Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis

Multimodality Imaging of Pancreatic and Biliary Congenital Anomalies

Management of Pancreatic Calculi in Chronic Pancreatitis: A Review Article

Contact Info

Product

Resources

About