Pathogenesis of oral squamous cell carcinoma- An update

Abstract

Oral cancer is the sixth most common malignancy in the world. Oral cancer is of major concern in Southeast Asia primarily because of the deleterious habits such as smoking, betel nut chewing and alcohol consumption. Despite recent advances in cancer diagnoses and therapies, the survival rate of oral cancer patients has remained at a dismal 50% in the last few decades. This paper is an overview of the various etiological agents and risk factors implicated in the development of oral cancer.

Comparative evaluation of XPD and XPG gene polymorphism in oral squamous cell carcinoma and tobacco chewers: An observational study

“…More than 90% of OSCC has shown association with tobacco habit. [ 6 ] The disproportionately higher incidence of OSCC in relation to other malignancies in India may be due to the use of tobacco in various forms, consumption of alcohol, low socioeconomic condition related to poor hygiene, poor diet, and rampant viral infections. [ 7 ]…”