Pathogenesis of meningo-encephalitis produced in calves by infectious bovine rhinotracheitis herpesvirus

Bagust, T. J.; Clark, Leigh

doi:10.1016/0021-9975(72)90036-9

Cited by 73 publications

(66 citation statements)

References 12 publications

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“…Todos os animais estudados apresentaram achados histoló-gicos característicos de infecção por BHV-5, evidenciados por meningoencefalite difusa, não supurativa, associada a necrose do córtex cerebral e, exceto em 3 casos, à presença de corpúsculos de inclusão intranucleares eosinofílicos ou basofílicos em astrócitos e neurônios (Bagust & Clark 1972, Hill et al 1984.…”

Section: Discussionunclassified

“…Esses fatos sugerem que, inicialmente, as lesões podem ocorrer mais gravemente no tronco encefálico, evoluindo posteriormente para a região cortical. Estas conclusões estariam de acordo com Bagust & Clark (1972), que encontraram o vírus em níveis detectáveis apenas na região do tronco encefálico com 6 dias decorridos da inoculação experimental, e no tronco encefálico e córtex no 8º dia, sendo difusa a infeção viral a partir do 11º dia após a inoculação.…”

Section: Discussionunclassified

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Meningoencefalite em bovinos causada por herpesvírus bovino-5 no Mato Grosso do Sul e São Paulo

et al. 1998

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Fifteen outbreaks of bovine herpesvirus-type 5 (BHV-5) infection were diagnosed from August 1993 to December 1996. Fourteen outbreaks occurred in the State of Mato Grosso do Sul and one in the State of São Paulo. Cattle 6 to 60 months old were affected. Morbidity reached 0.05% to 5% and case fatality rate was nearly 100%. The disease occurred in different municipalities and at different times of the year. Clinical signs were exclusively nervous, and the clinical course varied from 1 to 15 days. The main histologic lesions were meningitis, diffuse encephalitis and necrosis of the cerebral cortex with intranuclear inclusion bodies in astrocytes and neurons. BHV-5 was isolated from 11 out of 12 brains of infected animals inoculated in calf testis cells and MDBK cells. The virus was identified by immunoperoxidase staining with use of monoclonal specific antibodies. Outbreaks of infection by BHV-5 represent 5% of the total number of bovine cases submitted for diagnosis to the Clinical Hospital of the University of Mato Grosso do Sul. These results indicate the importance of the disease in Mato Grosso do Sul and the need for its differentiation from other diseases which affect the nervous system. INDEX TERMS: Meningoencephalitis, bovine herpesvirus-5, BHV-5, cortical cerebral necrosis, cattle, Mato Grosso do Sul.1 Aceito para publicação em 6 de março de 1998. Os sinais clínicos foram exclusivamente nervosos e o curso da enfermidade variou de 1 a 15 dias. As principais lesões histológicas detectadas foram meningite e encefalite difusa com malacia do córtex cerebral e presença de corpúsculos de inclusão intranucleares em astrócitos e neurônios. O vírus foi isolado do cérebro de 11 de um total de 12 animais, e sua identidade confirmada por imunoperoxidase, utilizando-se anticorpos monoclonais específicos. Os surtos de encefalite por BHV-5 representam 5% dos diagnósticos realizados em bovinos pelo Hospital Veterinário da Universidade Federal do Mato Grosso do Sul. Os resultados deste trabalho evidenciam a importância da doença no Mato Grosso do Sul e indicam a necessidade de incluir a encefalite por BHV-5 no diagnóstico diferencial de outras doenças do sistema nervoso de bovinos frequentes no Estado. TERMOS DE INDEXAÇÃO: Meningoencefalite, herpesvírus bovino-5, BHV-5, polioencefalomalacia, bovinos, Mato Grosso do Sul.

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Section: Discussionunclassified

Meningoencefalite em bovinos causada por herpesvírus bovino-5 no Mato Grosso do Sul e São Paulo

et al. 1998

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“…Comparative experiments of inoculation with BoHV-1 and BoHV-5 have been carried out in cattle [5,6,11,51,83,111]. After primary infection by intranasal inoculation, BoHV-1 and BoHV-5 replicate at the portal of entry in the respiratory mucosa [6].…”

Section: Bovine Herpesvirusmentioning

confidence: 99%

“…The dissemination of BoHV-5 infection probably follows the same three routes as BoHV-1: blood, nervous system and cellto-cell spread [6,11,51,82,91]. BoHV-5 induces a replication cycle in the cells of the respiratory epithelium and reaches the nervous system by a mechanism strongly associated with intra-axonal transport.…”

Section: Bovine Herpesvirusmentioning

confidence: 99%

“…Commercially available BoHV-1 gB blocking ELISA has been tried in other animal species, namely goats and red deer. Compared to CpHV-1 seroneutralisation, this test, applied to the detection of anti-CpHV-1 antibodies in goats, exhibits a relative sensitivity of 95.8% ± 2.4% for experimental sera and 5 98.7% ± 2.5% for field sera, as well as a relative specificity of 96.9% ± 2.5% for experimental sera and 91.4% ± 9.2% for field sera 6 . These good relative intrinsic values are enough to recommend their use at the herd level but not on an individual basis.…”

Section: Serological Diagnosismentioning

confidence: 99%

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Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

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