Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors

Weiner, Shoshana; Neragi-Miandoab, Siyamek

doi:10.1007/s00432-008-0444-9

Cited by 44 publications

(12 citation statements)

References 129 publications

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“…Mechanistic studies in cell cultures and in rodents suggest that SV40 viral oncoproteins induce mesothelial cell transformation and diffuse malignant mesothelioma, although human epidemiological studies do not support a causal association (Weiner & Neragi-Miandoab, 2009). Additional epidemiological studies using specific serological markers for SV40 virus infections are needed (Kean et al, 2009).…”

Section: Knowledge and Data Gaps For The Biologic Mechanisms For Neopmentioning

confidence: 99%

Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure

Broaddus

Everitt

Black

et al. 2011

Journal of Toxicology and Environmental Health, Part B

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Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research.

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Section: Knowledge and Data Gaps For The Biologic Mechanisms For Neopmentioning

confidence: 99%

Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure

Broaddus

Everitt

Black

et al. 2011

Journal of Toxicology and Environmental Health, Part B

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“…While asbestos is generally accepted as a risk factor for the majority of mesotheliomas (70-80%), several other potentially causal factors have been identified [2], including micro-environmental exposures to fibers from volcanic rocks [3,4]; exposure to chemicals such as beryllium [5,6] and liquid paraffin [7]; and chronic irritation, inflammation [8,9], and infection [10]. Recent reports have suggested that the SV40 virus may also contribute to the development of mesothelioma [11][12][13], and that there may be a genetic susceptibility to mesothelioma [11].…”

Section: Introductionmentioning

confidence: 99%

Ionizing radiation: a risk factor for mesothelioma

Goodman

Nascarella

Valberg

2009

Cancer Causes Control

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In the majority of mesothelioma cases worldwide, asbestos is a likely causal factor, but several alternative factors, such as ionizing radiation, have been recognized. We reviewed ionizing-radiation evidence from epidemiology studies of (1) patients exposed to the diagnostic X-ray contrast medium "Thorotrast," (2) patients undergoing radiation therapy (i.e., to treat cancer), and (3) atomic energy workers chronically exposed to lower levels of radiation. The results from these populations are also supported by case reports of mesothelioma following therapeutic radiation. Statistically significant associations were found in many, but not all, epidemiology studies (particularly those of Thorotrast- and radiation-treated patients). Given the low mesothelioma rate in the general population, the consistently increased risk among these radiation-exposed individuals is noteworthy. Many studies were limited by the lack of a uniform manner in which mesothelioma was reported prior to introduction of a uniform classification system (ICD-10). Future studies that rely on ICD-10 should have greater power to detect an association. While the evidence falls short of a definitive causal link, considering studies in which statistical significance was achieved, the case reports, and the plausible mode of action, we conclude that the evidence is supportive of a causal link between ionizing radiation exposure and mesothelioma risk.

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“…[ 2 ] Risk factors for mesothelioma include occupational or industrial exposure to amphibole type asbestos fibers, genetic predisposition, and radiation. [ 3 ] The risk factors for pleural and peritoneal mesotheliomas are similar; however, asbestos exposure is more frequently associated with pleural disease.…”

Section: Introductionmentioning

confidence: 99%

Personalized Oncogenomics: Clinical Experience with Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing

et al. 2015

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Peritoneal mesothelioma is a rare and sometimes lethal malignancy that presents a clinical challenge for both diagnosis and management. Recent studies have led to a better understanding of the molecular biology of peritoneal mesothelioma. Translation of the emerging data into better treatments and outcome is needed. From two patients with peritoneal mesothelioma, we derived whole genome sequences, RNA expression profiles, and targeted deep sequencing data. Molecular data were made available for translation into a clinical treatment plan. Treatment responses and outcomes were later examined in the context of molecular findings. Molecular studies presented here provide the first reported whole genome sequences of peritoneal mesothelioma. Mutations in known mesothelioma-related genes NF2, CDKN2A, LATS2, amongst others, were identified. Activation of MET-related signaling pathways was demonstrated in both cases. A hypermutated phenotype was observed in one case (434 vs. 18 single nucleotide variants) and was associated with a favourable outcome despite sarcomatoid histology and multifocal disease. This study represents the first report of whole genome analyses of peritoneal mesothelioma, a key step in the understanding and treatment of this disease.

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Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors

Cited by 44 publications

References 129 publications

Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure

Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure

Ionizing radiation: a risk factor for mesothelioma

Personalized Oncogenomics: Clinical Experience with Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing

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