Pathogenesis of large vessel vasculitis: Implications for disease classification and future therapies

Harky, Amer; Fok, Matthew; Balmforth, Damian; Bashir, Mohamad

doi:10.1177/1358863x18802989

Cited by 30 publications

(25 citation statements)

References 97 publications

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“…The prevalence in USA is estimated at 0.3/100,000, thus 1/100 of that of GCA 3 . The pathophysiological mechanisms in TA are similar to GCA 4 . Genetic associations for TA have been shown with HLA loci and IL12B 4 .…”

mentioning

confidence: 86%

Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden

Thomsen¹,

Li²,

Sundquist³

et al. 2020

Sci Rep

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Giant cell arteritis (GCA, also called temporal arteritis) is a rare and Takayasu arteritis (TA) is an even rarer autoimmune disease (AID), both of which present with inflammatory vasculitis of large and medium size arteries. The risk factors are largely undefined but disease susceptibility has been associated with human leukocyte antigen locus. Population-level familial risk is not known. In the present nation-wide study we describe familial risk for GCA and for GCA and TA with any other AID based on the Swedish hospital diagnoses up to years 2012. Family relationships were obtained from the Multigeneration Register. Familial standardized incidence ratios (SIRs) were calculated for offspring whose parents or siblings were diagnosed with GCA, TA or any other AID. The number of GCA patients in the offspring generation was 4695, compared to 209 TA patients; for both, familial patients accounted for 1% of all patients. The familial risk for GCA was 2.14, 2.40 for women and non-significant for men. GCA was associated with 10 other AIDs and TA was associated with 6 other AIDs; both shared associations with polymyalgia rheumatica and rheumatoid arthritis. The results showed that family history is a risk factor for GCA. Significant familial associations of both GCA and TA with such a number of other AIDs provide evidence for polyautoimmunity among these diseases.

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mentioning

confidence: 86%

Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden

Thomsen¹,

Li²,

Sundquist³

et al. 2020

Sci Rep

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“…The open surgery was deemed at high surgical risk because of the extreme friability of the aortic tissue due to the arteritic active phase according to histopathological features. 2 After written informed consent, the procedure was performed under general anesthesia and cerebrospinal fluid drainage. Through open tetralateral limb access, the brachial arteries were cannulated with a 9F Cook Flexor introducer (Cook Medical, Bloomington, IN, USA), whereas the femoral arteries were cannulated with 20F on the right and 12F on the left introducer sheaths (GORE DrySeal Flex, W.L.…”

Section: Case Reportmentioning

confidence: 99%

Thoracoabdominal Aortic Aneurysm Secondary to Aggressive Giant Cell Arteritis

Bozzani

Bobbio-Pallavicini

Arici

et al. 2020

Annals of Vascular Surgery

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“…This is supported by histological evidence of a granulomatous panarteritis with cell wall infiltration of the vessel. 1,28,29 A key activator in the inflammatory process seems to be the expression of the 65 kDa heat-shock protein in the aortic tissue; however, it is unclear as to what initiates the heat-shock protein. The heat-shock proteins induce the major histocompatibility class I chain-related A (MICA) on vascular smooth muscle, which is recognized by γδ T cells and NK cells.…”

Section: Pathogenesis Of Takayasu's Arteritismentioning

confidence: 99%

Current Controversies in Large-Vessel Inflammatory Vasculitis and Thoracic Aortic Aneurysm Disease

et al. 2019

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Large-vessel vasculitis encompasses the spectrum of vasculitides, which pathologically cause chronic granulomatous inflammatory changes, primarily in the aorta and its major branches. These patients are at risk of developing life-threatening aortic lesions that, without recognition and prompt treatment, can cause detrimental effects. Many provocative issues surrounding large-vessel vasculitis and its surgical treatment still remain, spanning from recognition to management. In this review, we discuss the main large-vessel vasculitides, Takayasu's arteritis and giant cell arteritis. We include the key points and current controversies surrounding diagnostic imaging, timing of interventions, and patient outcomes.

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Pathogenesis of large vessel vasculitis: Implications for disease classification and future therapies

Cited by 30 publications

References 97 publications

Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden

Familial risks between giant cell arteritis and Takayasu arteritis and other autoimmune diseases in the population of Sweden

Thoracoabdominal Aortic Aneurysm Secondary to Aggressive Giant Cell Arteritis

Current Controversies in Large-Vessel Inflammatory Vasculitis and Thoracic Aortic Aneurysm Disease

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