Pathogenesis of juvenile nasopharyngeal fibroma

Maurice, Matthew J.; Milad, M

doi:10.1017/s0022215100091891

Cited by 22 publications

(16 citation statements)

References 17 publications

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“…They are by some authors considered to be true neoplasms, exposing androgen receptors or activated transforming growth factor beta‐1 within the neoplasm . Other authors suggested a vascular origin, a specific variant of angioma, reactive overgrowth of connective tissue, irregular vessels set in fibrous stroma typical for vascular malformations, a result of pituitary‐dependent sex‐hormone dysfunction or hamartoma . Finally, angiofibromas are acknowledged as a vascular malformation deriving from an incomplete regression of the first branchial arch artery.…”

Section: Discussionmentioning

confidence: 99%

Extranasopharyngeal angiofibroma revisited

Windfuhr

Vent

2017

Clinical Otolaryngology

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Background Angiofibromas in the head and neck region usually arise in the nasopharynx, but may also occur elsewhere. This study aims at evaluating the incidence and clinical features of extranasopharyngeal angiofibroma (ENA). Material and Methods Systematic review of the literature (Medline® and Google™) up to 31 December 2015. Results 174 cases of ENA were retrieved from a total of 170 publications. In contrast to former publications and previous understanding, the nasal septum was by far the most common site of the disease. Four patients had a congenital lesion, the oldest patient was 87 years old (mean: 28.7 years; median: 23 years). Male gender was predominantly affected, but the sex ratio was more balanced (2.13:1) than in previous reports in the literature until 12/2015. The majority of patients presented with nasal obstruction, either in combination with epistaxis (25.8%) or other symptoms (12.6%). Symptoms had developed within 13.1 months on average (median: 4 months). Brisk bleeding resulted in 11 of 43 biopsy procedures. Surgical resection as first‐line therapy was performed in 170 patients. A tumour regrowth within 12 months was registered in four patients. Conclusion The increasing awareness of ENA and the willingness to publish case reports—not only in Medline‐listed journals—resulted in a significant increase of published case reports lately. Although extremely rare, ENAs have to be taken into account in the differential diagnosis of unclear masses, particularly in adult patients presenting with a rapidly developing nasal obstruction resulting from a nasal septum tumour. Female gender or normal vascularity does not exclude the diagnosis. Transnasal resection is sufficient in most cases, and recurrences are rare. Pathologists as well as clinicians should consider ENA in their differential diagnosis of any mass of the upper airway.

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Section: Discussionmentioning

confidence: 99%

Extranasopharyngeal angiofibroma revisited

Windfuhr

Vent

2017

Clinical Otolaryngology

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“…Schiff, 1959, proposed that the tumor growth should be related to the vascular component while the connective tissue content would correspond to the activity of the sex hormone sensitive tissue, following a disturbance of pituitary activity (Table 3.3). Maurice, in 1981, from pathological studies of JAF tumors and penilecavernous tissue, found enough similarities to support the concept that ectopic genital erectile tissue in the choanal region represented the same target cells. Johns, MacLeod et al in 1980 introduced the notion of target cells, located in the nasopharynx and dormant before puberty.…”

Section: D) Global Hypothesis For the Development Of Lafmentioning

confidence: 75%

“…Electron microscopy has not yet completely classified the function of the stroma. This would account for some cases of so called spontaneous regression and provide some rationale for tumors seen after adolescence, which tend to have a slower rate of growth, a higher proportion of fibrous tissue and less tendency to bleed (Maurice, 1981). Various authors have tried to show a correlation between the spectrum of histopathologic findings and the variable clinical presentations.…”

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confidence: 99%

Surgical Neuroangiography

Lasjaunias¹,

Berenstein²

1987

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“…Einige Autoren lehnen die Entstehung im Nasopharynx ab [28,29]. Angiofibrome wurden aber auch als Neoplasien [19 ± 22], Gefäûtumoren [34], Variante eines Angioms [35], reaktives übermäûiges Wachstum von Bindegewebe [36], irreguläre Gefäûbildungen in Bindegewebe wie bei vaskulä-ren Malformationen [37], Ergebnis einer Hypophysen-abhängi-gen hormonellen Dysfunktion [16] oder Hamartom [38,39] angesehen. Der Einfluss von Sexualhormonen ist immer wieder erwähnt worden [2,40], Farag gelang bereits 1987 der Nachweis von Androgen-spezifischen Rezeptoren [41].…”

Section: Diskussionunclassified

Extranasopharyngeale Angiofibrome der Nasenhaupt- und -nebenhöhlen

Remmert²

2004

Laryngorhinootologie

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Extranasopharyngeal angiofibromas of the nasal cavity or paranasal sinuses should be included in the differential diagnosis of nasal tumors. Compared to nasopharyngeal angiofibromas, more female patients are involved, symptoms develop more quickly but hypervascularity is less common. Signs of questionable hypervascularity in Computed Tomography and Magnetic Resonance Imaging (MRI) should indicate arteriography prior to surgical procedures. Preoperative embolization of hypervascular lesions during arteriography will reduce the risk of brisk bleeding during biopsy or surgical tumor removal.

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Pathogenesis of juvenile nasopharyngeal fibroma

Cited by 22 publications

References 17 publications

Extranasopharyngeal angiofibroma revisited

Extranasopharyngeal angiofibroma revisited

Surgical Neuroangiography

Extranasopharyngeale Angiofibrome der Nasenhaupt- und -nebenhöhlen

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