Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Song, Yan; Huang, Xiaohan; Yu, Ge-Ping; Qiao, Jianjun; Cheng, Jun; Wu, Jianyong; Chen, Jianghua

doi:10.3389/fimmu.2021.771619

Cited by 67 publications

(82 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, some see IgA nephropathy and IgAVN as different expressions of the same disease [29][30][31]. Clinical course and extrarenal manifestations are necessary to differentiate IgA nephropathy and IgAVN.…”

Section: Discussionmentioning

confidence: 99%

Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up

et al. 2022

View full text Add to dashboard Cite

Background There is scarce information on biopsy-verified kidney disease in childhood and its progression to chronic kidney disease stage 5 (CKD 5). This study aims to review biopsy findings in children, and to investigate risk of kidney replacement therapy (KRT). Methods We conducted a retrospective long-term follow-up study of children included in the Norwegian Kidney Biopsy Registry (NKBR) and in the Norwegian Renal Registry (NRR) from 1988 to 2021. Results In total, 575 children with a median (interquartile range, IQR) age of 10.7 (6.1 to 14.1) years were included, and median follow-up time (IQR) after kidney biopsy was 14.3 (range 8.9 to 21.6) years. The most common biopsy diagnoses were minimal change disease (MCD; n = 92), IgA vasculitis nephritis (IgAVN; n = 76), IgA nephropathy (n = 63), and focal and segmental glomerulosclerosis (FSGS; n = 47). In total, 118 (20.5%) of the biopsied children reached CKD 5, median (IQR) time to KRT 2.3 years (7 months to 8.4 years). Most frequently, nephronophthisis (NPHP; n = 16), FSGS (n = 30), IgA nephropathy (n = 9), and membranoproliferative glomerulonephritis (MPGN; n = 9) led to KRT. Conclusions The risk of KRT after a kidney biopsy diagnosis is highly dependent on the diagnosis. None of the children with MCD commenced KRT, while 63.8% with FSGS and 100% with NPHP reached KRT. Combining data from kidney biopsy registries with registries on KRT allows for detailed information concerning the risk for later CKD 5 after biopsy-verified kidney disease in childhood. Graphical abstract A higher resolution version of the Graphical abstract is available as Supplementary information

show abstract

Section: Discussionmentioning

confidence: 99%

Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up

et al. 2022

View full text Add to dashboard Cite

show abstract

“…IgA vasculitis is an immune complex-mediated small-vessel vasculitis characterized by IgA1-dominant immune deposits in vessel walls [1]. Typically, IgA vasculitis occurs after an upper respiratory tract infection, although the pathogenesis of IgA vasculitis is still not completely understood.…”

Section: Discussionmentioning

confidence: 99%

Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines

et al. 2022

View full text Add to dashboard Cite

IgA vasculitis is an immune complex-mediated small-vessel vasculitis that mainly occurs in children and is characterized by palpable purpura, arthralgia, abdominal pain, and glomerulonephritis. We report three cases of new-onset IgA vasculitis involving major organs in adult patients after they received either the ChAdOx1 viral vector (Oxford/AstraZeneca) vaccine or the messenger RNA-1273 (Moderna) vaccine. These cases suggest that COVID-19 vaccines have the potential to trigger IgA vasculitis and indicate that physicians need to monitor for this possible complication.

show abstract

“…IgAV is the most common small vessel inflammatory disease in childhood and worldwide and mainly involves the small vasculature of the skin, joints, gastrointestinal tract and kidneys ( 8 ). The clinical manifestations of IgAVN are mainly hematuria and proteinuria, which long-term prognosis depends on the severity of renal damage ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

Risk assessment and prediction model of renal damage in childhood immunoglobulin A vasculitis

Yang

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

ObjectivesTo explore the risk factors for renal damage in childhood immunoglobulin A vasculitis (IgAV) within 6 months and construct a clinical model for individual risk prediction.MethodsWe retrospectively analyzed the clinical data of 1,007 children in our hospital and 287 children in other hospitals who were diagnosed with IgAV. Approximately 70% of the cases in our hospital were randomly selected using statistical product service soltions (SPSS) software for modeling. The remaining 30% of the cases were selected for internal verification, and the other hospital's cases were reviewed for external verification. A clinical prediction model for renal damage in children with IgAV was constructed by analyzing the modeling data through single-factor and multiple-factor logistic regression analyses. Then, we assessed and verified the degree of discrimination, calibration and clinical usefulness of the model. Finally, the prediction model was rendered in the form of a nomogram.ResultsAge, persistent cutaneous purpura, erythrocyte distribution width, complement C3, immunoglobulin G and triglycerides were independent influencing factors of renal damage in IgAV. Based on these factors, the area under the curve (AUC) for the prediction model was 0.772; the calibration curve did not significantly deviate from the ideal curve; and the clinical decision curve was higher than two extreme lines when the prediction probability was ~15–82%. When the internal and external verification datasets were applied to the prediction model, the AUC was 0.729 and 0.750, respectively, and the Z test was compared with the modeling AUC, P > 0.05. The calibration curves fluctuated around the ideal curve, and the clinical decision curve was higher than two extreme lines when the prediction probability was 25~84% and 14~73%, respectively.ConclusionThe prediction model has a good degree of discrimination, calibration and clinical usefulness. Either the internal or external verification has better clinical efficacy, indicating that the model has repeatability and portability.Clinical trial registration:www.chictr.org.cn, identifier ChiCTR2000033435.

show abstract

Pathogenesis of IgA Vasculitis: An Up-To-Date Review

Cited by 67 publications

References 130 publications

Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up

Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up

Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines

Risk assessment and prediction model of renal damage in childhood immunoglobulin A vasculitis

Contact Info

Product

Resources

About