Pathogenesis of<i>Brucella</i>epididymoorchitis-game of<i>Brucella</i>death

Yu, Jiuwang; Li, Sha; Wang, Lu; Zhao, Dong; Si, Lengge; Wu, Lan

doi:10.1080/1040841x.2021.1944055

Cited by 7 publications

(4 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to age, recent data suggested that osteoarticular complications were related to a genetic predisposition and HLA-B39. 6 Brucella is characterized by strong tissue tropism for reproductive systems, 16 and drives clinical disease manifestations and pathology. The prevalence of epididymoorchitis ranged from 3.4% to 10%, 8,23 and most patients with epididymoorchitis were in acute stage.…”

Section: Discussionmentioning

confidence: 99%

“…Usually, brucellosis in human is not lethal; 1 whereas if treated improperly, persistent intracellular infection may result in chronic and severe complications including arthritis and spondylitis, which subsequently leads to high rate of disability. 3,5,6 It was reported that 10-30% of patients developed to chronic brucellosis and suffered from persistent complications, despite early diagnosis and treatment. 7 However, little is known about the differences in epidemiology and clinical characteristics between patients with acute and chronic brucellosis, as well as those with and without focal complications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China

Zhang¹,

Chen²,

Xiao³

et al. 2022

IJGM

View full text Add to dashboard Cite

Brucellosis is an ongoing zoonotic disease in China, but there are few data in Beijing. This study was designed to illustrate clinical characteristics of patients with brucellosis in Beijing, China and explore the risk factors for focal brucellosis. Patients and Methods: Data of patients with brucellosis were retrospectively collected from the patients' electronic medical records in Beijing Youan Hospital during 2010 to 2021, including epidemiological, demographic and clinical features. Risk factors for focal brucellosis were identified by multivariable logistic regression models. Results: A total of 197 patients were included in the study, with 165 (83.8%) cases in acute phase and 32 (16.2%) cases in chronic phase. Patients in acute phase were more likely to have splenomegaly (24.2% vs 3.1%, p=0.007) than those in chronic phase, but had less arthralgia (62.4% vs 81.3%, p=0.040). The median level of alanine aminotransferase (36.9 vs 20.7, p=0.001) was higher in patients at acute stage than those at chronic stage. Of all the patients, 76 (38.6%) were reported with focal complications, including 16 (8.1%) peripheral arthritis, 36 (18.3%) spondylitis, 17 (8.6%) epididymoorchitis, 8 (4.1%) meningitis and 3 (1.3%) endocarditis. Additionally, male (OR 2.76, 95% CI 1.15-6.64, p = 0.023), arthralgia (OR 6.23, 95% CI 2.36-16.43, p < 0.001) and higher level of platelets (OR 1.01, 95% CI 1.00-1.01, p < 0.001) were the independent risk factors for focal brucellosis. Conclusion:The control of human brucellosis still cannot be ignored due to the re-emerging cases in Beijing, which are more likely to present splenomegaly and abnormal liver function in acute phase. Moreover, male, arthralgia and high level of platelets were the independent risk factors for focal brucellosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China

Zhang¹,

Chen²,

Xiao³

et al. 2022

IJGM

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5] In addition to SSCs and spermatocytes in the testis, other somatic cells are involved in the spermatogenesis process, such as Sertoli cells that support and nourish germ cells, 6 Leydig cells that secrete androgens, 7 peritubular myoid cells that provide a telescoping function for the seminiferous tubule, 8 and testicular macrophages that mediate immune homeostasis. 9 The blood-testis barrier (BTB) in the testis is resistant to the invasion of most pathogenic microbes; however, several microbes, such as Brucella, 10 and several RNA viruses 11 can disrupt the structure and function of the BTB, impair the homeostasis of SSCs and affect the testicular microenvironment, leading to abnormal spermatogenesis and reduced fertility. In addition, various hormones, secretory factors, and epigenetic factors in the testis are involved in the spermatogenesis process and are closely associated with posttranslational modifications.…”

Section: Introductionmentioning

confidence: 99%

UCHL1 maintains microenvironmental homeostasis in goat germline stem cells

Yang,

Zhang,

Chen

et al. 2023

The FASEB Journal

View full text Add to dashboard Cite

Spermatogonial stem cells (SSCs) play a crucial role in mammalian spermatogenesis and maintain the stable inheritance of the germline in livestock. However, stress and bacterial or viral infections can disrupt immune homeostasis of the testes, thereby leading to spermatogenesis destruction and infertility, which severely affects the health and productivity of mammals. This study aimed to explore the effect of ubiquitin C‐terminal hydrolase L1 (UCHL1) knockdown (KD) in goat SSCs and mouse testes and investigate the potential anti‐inflammatory function of UCHL1 in a poly(I:C)‐induced inflammation model to maintain microenvironmental homeostasis. In vitro, the downregulation of UCHL1 (UCHL1 KD) in goat SSCs increased the expression levels of apoptosis and inflammatory factors and inhibited the self‐renewal and proliferation of SSCs. In vivo, the structure of seminiferous tubules and spermatogenic cells was disrupted after UCHL1 KD, and the expression levels of apoptosis‐ and inflammation‐related proteins were significantly upregulated. Furthermore, UCHL1 inhibited the TLR3/TBK1/IRF3 pathway to resist poly(I:C)‐induced inflammation in SSCs by antagonizing HSPA8 and thus maintaining SSC autoimmune homeostasis. Most importantly, the results of this study showed that UCHL1 maintained immune homeostasis of SSCs and spermatogenesis. UCHL1 KD not only inhibited the self‐renewal and proliferation of goat SSCs and spermatogenesis but was also involved in the inflammatory response of goat SSCs. Additionally, UCHL1 has an antiviral function in SSCs by antagonizing HSPA8, which provides an important basis for exploring the specific mechanisms of UCHL1 in goat spermatogenesis.

show abstract

“…People are often infected with Brucella after eating animal products such as unpasteurized milk and meat or coming into direct contact with infected animals. Many large livestock are also afflicted by Brucellosis, leading to reduced productivity and hampered development of the industry [ 3 , 4 , 5 ]. According to incomplete statistics, there are at least 500,000 cases of Brucella infection worldwide every year [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

Xiao

Guo

et al. 2022

IJMS

View full text Add to dashboard Cite

Brucellosis is a severe zoonotic infectious disease caused by the infection of the Brucella, which is widespread and causes considerable economic losses in underdeveloped areas. Brucella is a facultative intracellular bacteria whose main target cells for infection are macrophages, placental trophoblast cells and dendritic cells. The main clinical signs of Brucella infection in livestock are reproductive disorders and abortion. At present, the pathogenesis of placentitis or abortion caused by Brucella in livestock is not fully understood, and further research on the effect of Brucella on placental development is still necessary. This review will mainly introduce the research progress of Brucella infection of placental trophoblast cells as well as the inflammatory response caused by it, explaining the molecular regulation mechanism of Brucella leading to reproductive system disorders and abortion, and also to provide the scientific basis for revealing the pathogenesis and infection mechanism of Brucella.

show abstract

Pathogenesis ofBrucellaepididymoorchitis-game ofBrucelladeath

Cited by 7 publications

References 169 publications

Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China

Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China

UCHL1 maintains microenvironmental homeostasis in goat germline stem cells

Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

Contact Info

Product

Resources

About