:Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model

Mycobacteriosis in naturally infected ring-neck doves (Streptopelia risoria): investigation of the association between feather colour and susceptibility to infection, disease and lesions type

“…However, it is more likely that these birds had recently overcome a mycobacterial infection through a mild but adequate cell-mediated immune response. It is probable that the mild lesions observed in these four birds represented a controlled or at least an arrested infection, similar to that seen in other mycobacterial infections (Jubb et al, 1993;Cotran et al, 1999;Dannemberg, 2006). It suggests that at least some birds may recover from natural infection.…”

“…Both environmental and genetic factors and their interaction influence susceptibility to tuberculosis in humans (Casanova & Abel, 2002;Schurr, 2007), in laboratory animals such as rabbits and mice, and in domestic mammals (Barthel et al, 2000;Phillips et al, 2002;Di Pietrantonio & Schurr, 2005;Dannemberg, 2006). For example, in humans infected with M. tuberculosis, less than 10% of infections progress to clinical disease (Cole et al, 2004).…”

The Cellular Immune Response to Mycobacterium tuberculosis Infection in the Guinea Pig

“…Current concepts of the pathogenesis in the guinea pig is based on early studies (28,30,42). This model supports during acute infection with M. tuberculosis the initial presence of bacilli results in the absence of tissue damage.…”

Establishment of A Guinea Pig Model of Latent Tuberculosis with GFP-introduced Mycobacterium Tuberculosis

“…Humans and rabbits infected with M. tuberculosis develop cavities in the lungs, whereas guinea pigs do not (Dannenberg 2006). After reactivation of latent infection or exogenous reinfection with M. tuberculosis, caseous lesions and cavities may develop.…”