Pathogenesis of Generalized Dermal Pigmentation Secondary to Malignant Melanoma and Melanuria*

Fitzpatrick, Thomas B.; Montgomery, Hamilton; Lerner, Aaron B.

doi:10.1038/jid.1954.22

Cited by 60 publications

(19 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diffuse melanosis in malignant melanoma is clinically characterized by a striking argyria-like slate-blue discolouration of the skin and melanuria (Albertini & Walthard 1927,Odel & Horton 1937, Dixon 1938, Albeaux-Fernet, Laumonier & Collart 1949, Ritz 1949, Fitzpatrick, Montgomery & Lerner 1954, Goodall & Spriggs 1961, Silberberg, Kopf & Gumport 1968, Bork, Korting & Rumpelt 286 J.Eide 1977. The bluish colour is due to deposition of melanin pigment in the deeper part of the dermis (Ode1 & Horton 1937, Albeaux-Fernet et al 1949, Fitzpatrick et al 1954, Goodall & Spriggs 1961, Silberberg et al 1968, ,Holcomb et al 1975, Bork et al 1977.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Eide

1981

Histopathology

View full text Add to dashboard Cite

A case of disseminated malignant melanoma with generalized melanosis of the skin and other tissues, melanuria, melanoptysis, and a dark brown blood serum is reported. The reticuloendothelial system contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally, in other cells, was noted. Single cell metastases contributed to melanin pigmentation of most organs, but were not found in sections of the skin. Melanoptysis (black sputum) was due to diffuse melanoma cell infiltration of the lungs, with secondary pigment deposition in macrophages and in bronchial epithelial cells. In this case the 'glomerular melanoma cell emboli' recorded by previous authors consisted of melanin pigment and cell debris. Focal damage of glomeruli affected by pigment emboli is described allowing access of melanoma cell debris (including melanin pigment granules) into glomerular tubules.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The bluish colour is due to deposition of melanin pigment in the deeper part of the dermis (Ode1 & Horton 1937, Albeaux-Fernet et al 1949, Fitzpatrick et al 1954, Goodall & Spriggs 1961, Silberberg et al 1968, ,Holcomb et al 1975, Bork et al 1977.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Eide

1981

Histopathology

View full text Add to dashboard Cite

show abstract

“…This theory has been supported by the documented observations of melanin precursors, melanin, melanosomes, and melanophages in patients’ serum. [3,6,11] …”

Section: Discussionmentioning

confidence: 99%

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Maj

Jankowska‐Konsur²,

Gruber³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.Patient concerns:A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization.Diagnosis:Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis.Interventions:The patient refused to the treatment.Outcomes:The patient died eight months after DMC appeared.Lessons:DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom.

show abstract

“…The clinical appearance can be variable from slate-blue to slate-gray [1,3,4]. In some cases, an accentuation of the melanosis in sun-exposed regions was reported [3,5]. It appears that there is no localization of the primary melanoma predisposing to generalized melanosis.…”

Section: Discussionmentioning

confidence: 99%

“…According to these clinical observations, 3 of our 4 patients died 1, 8 and 8 weeks, respectively, after the melanosis cutis had become first apparent. The clinical appearance can be variable from slate-blue to slate-gray [1,3,4]. In some cases, an accentuation of the melanosis in sun-exposed regions was reported [3,5].…”

Section: Discussionmentioning

confidence: 99%

Diffuse Melanosis cutis in Disseminated Malignant Melanoma

Hofmann¹,

Kiecker²,

Audring³

et al. 2004

Dermatology

View full text Add to dashboard Cite

Pathogenesis of Generalized Dermal Pigmentation Secondary to Malignant Melanoma and Melanuria*

Cited by 60 publications

References 6 publications

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Diffuse Melanosis cutis in Disseminated Malignant Melanoma

Contact Info

Product

Resources

About