Pathogenesis of Fungal Infections in Cystic Fibrosis

Williams, Craig; Ranjendran, Ranjith; Ramage, Gordon

doi:10.1007/s12281-016-0268-z

Cited by 47 publications

(48 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cystic fibrosis (CF) is the most common monogenetic autosomal recessive disease in Northern Europe. The disease is caused by mutations in a cystic fibrosis transmembrane conductance regulator (CFTR) gene whose product is a chloride channel (Williams et al [ 1 ]). CFTR mutations result in reduced excretion of chloride ions in the apical membrane of epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…The colonization of the lower respiratory tract with microorganisms progresses with the duration of cystic fibrosis. In the early phases, the most common bacteria are Staphylococcus aureus and Haemophilus influenzae , whereas a wide range of bacteria, mainly Pseudomonas aeruginosa , Burkholderia cepacia complex, and other Gram-negative bacteria as well as fungal species, are isolated in the later stages of the disease [ 1 ]. There are several studies analyzing the prevalence of the pathogenic bacteria and fungi in patients with CF (for recent reviews, see [ 3 – 5 ]).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Coexistence of Candida species and bacteria in patients with cystic fibrosis

Haiko

Saeedi

Bagger

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Cystic fibrosis (CF) patients become colonized by pathogenic bacteria as well as by Candida species. The interplay between different microorganisms may play a key role in the prognosis of CF. The aim of the study was to analyze the coexistence patterns of bacteria and Candida spp. in sputum samples of patients with CF and to compare these patterns with the results of patients with other respiratory disorders (ORD). Sputum samples from 130 patients with CF and 186 patients with ORD were cultured on six different agar plates promoting the growth of bacteria and yeasts. Bacterial and Candida species were identified with MALDI-TOF MS. Pathogenic bacteria were found in 69.2% of the sputum samples of the CF patients, and in 44.1% the patients with ORD. CF patients tended to have growth of Pseudomonas aeruginosa and Staphylococcus aureus in sputum more often than patients with ORD. Overall, there was no difference in the coexistence of pathogenic bacteria and Candida spp. in these patient groups. However, when analyzed at the species level, P. aeruginosa and S. aureus coexisted with Candida spp. more frequently in sputum samples of CF patients compared with patients with ORD. Also, when analyzed according to age, it was shown that the adult (≥ 18 years) CF patients had a higher rate of coexistence of any pathogenic bacteria and Candida spp. than the children with CF and the adult patients with ORD. The rate for colonization with Candida together with pathogenic bacteria is increased in adult patients with CF.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coexistence of Candida species and bacteria in patients with cystic fibrosis

Haiko

Saeedi

Bagger

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…and Aspergillus spp.) [18] in the airways of people with CF, although their involvement in respiratory disease remains controversial and largely understudied [10,19,20]. Metagenomic studies have also revealed an impact of respiratory viral infections in CF airway damage [21][22][23], as well as the presence of bacterial viruses (phages) in CF airways [24,25].…”

mentioning

confidence: 99%

Deciphering the Ecology of Cystic Fibrosis Bacterial Communities: Towards Systems-Level Integration

Bevivino

Bacci

Dřevı́nek

et al. 2019

Trends in Molecular Medicine

View full text Add to dashboard Cite

“…However, as the disease progresses, the lung microbiome of patients with CF is dominated by the bacterium Pseudomonas aeruginosa [33]. Some recent studies have reported that co-colonisation of the airways by C. albicans or A. fumigatus with P. aeruginosa lead to more exacerbations and decreased lung function [34,35]. Other fungal species frequently detected in the airways from patients with CF include Penicillium species, nonfumigatus Aspergillus species, Scedosporium, Exophiala Fig.…”

Section: The Mycobiome and Chronic Lung Diseasesmentioning

confidence: 99%

The Human Lung Mycobiome in Chronic Respiratory Disease: Limitations of Methods and Our Current Understanding

Weaver

Gago

Bromley

et al. 2019

Curr Fungal Infect Rep

View full text Add to dashboard Cite

Purpose of the Review This review summarises the characteristics of the lung mycobiome in patients with chronic respiratory diseases and fungal lung diseases. We have also reviewed the limitations of the current methods in mycobiome studies. Recent Findings Available studies in the impacts of the mycobiome in chronic and fungal lung diseases are scarce and comparison of the available studies is hindered by heterogeneity in the sample sizes, methods and patient selection. Summary The impact of the diversity and composition of the lung mycobiome in chronic and fungal lung diseases is poorly understood. Most studies involve detection of fungi in respiratory samples by culture. However, such methods lack sensitivity and the emergence of next-generation sequencing technologies is an important advance. However, differences in the sequencing methodologies limit study comparisons. Well-designed methodological approaches and large cohort studies are needed to evaluate the impact of the lung mycobiome in respiratory diseases.

show abstract

Pathogenesis of Fungal Infections in Cystic Fibrosis

Cited by 47 publications

References 87 publications

Coexistence of Candida species and bacteria in patients with cystic fibrosis

Coexistence of Candida species and bacteria in patients with cystic fibrosis

Deciphering the Ecology of Cystic Fibrosis Bacterial Communities: Towards Systems-Level Integration

The Human Lung Mycobiome in Chronic Respiratory Disease: Limitations of Methods and Our Current Understanding

Contact Info

Product

Resources

About