Pathogenesis of Exercise-Induced Asthma: Implications for Treatment

Haltom, James R.; Strunk, Robert C.

doi:10.1146/annurev.me.37.020186.001043

Cited by 8 publications

(3 citation statements)

References 46 publications

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“…45 .4 6 Cigarette smoke, automobile exhaust fumes, and perfumes affect persons with asthma more than they do the general population. Practically speaking, many nonspecific irritants are difficult to avoid.…”

Section: Nonspecific Irritantsmentioning

confidence: 99%

Common triggers of asthma

Spector¹

1991

Postgraduate Medicine

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Control of asthma is enhanced when careful consideration is given to underlying mechanisms. Patients can be advised of ways to avoid or minimize contact with offending allergens, and, in some cases, pharmacologic management may not be necessary. Care must be taken when treating patients with concomitant disorders, such as hyperthyroidism. Also, psychological factors may have a role in exacerbating symptoms in suggestible patients. Noncompliance, in some cases due to inability to pay for medication, may be an unrecognized cause of treatment failure.

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Section: Nonspecific Irritantsmentioning

confidence: 99%

Common triggers of asthma

Spector¹

1991

Postgraduate Medicine

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“…Exercise is a common and troublesome precipitating factor in childhood asthma. 2 The severity of the exerciseinduced bronchospasm (EIB) is related to the intensity and duration of the exercise. It is important to recognize that a negative history for EIB does not rule out its presence, for many children with asthma have learned that they cannot exercise and then never exercise enough to induce bronchospasm.…”

Section: Identification Of Precipitating Factorsmentioning

confidence: 99%

An Approach to Pediatric Patients with Chronic Asthma

Strunk¹

1987

Semin Respir Crit Care Med

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“…The development of asthma is a complex interaction between genetics and a variety of environmental factors, both antenatal and postnatal. It is also clear that exacerbations can be triggered by a variety of environmental factors such as occupational exposures, 2 exercise, 3 soya bean dust, 4 fungal spores 5 and thunderstorms 6,7 and other factors such as the time of the menstrual cycle 8 . We are beginning to understand that the ‘asthma syndrome’ is a heterogenous group of disorders with different phenotypes 9 .…”

Section: Introductionmentioning

confidence: 99%

Patients with a longer duration of symptoms of acute asthma are more likely to require admission to hospital

2002

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Objective: To determine whether, for patients with moderate or severe asthma presenting to emergency departments, there is a difference in need for hospitalization between those with a duration of symptoms less than 6 h and those with a longer duration of symptoms. Methods: This prospective, observational study investigated a sample of patients presenting with acute asthma between 21 August and the 3 September 2000, attending study emergency departments and classified as having moderate or severe asthma according to the National Asthma Guidelines. Data collected included duration of symptoms (less than 6 h or greater than 6 h) and disposition following emergency department treatment (home, ward, intensive care unit, high dependency unit, transfer). Data analysis was by Chi square analysis. Results: Of 381 eligible patients, 348 had sufficient data for entry into this study (33 had missing data). Patients with duration of symptoms more than 6 h were more likely to require hospital admission (P < 0.0001). The relative risk for hospital admission or transfer as opposed to discharge from the emergency department for the group with a duration of symptoms of more than 6 h was 2.2. Conclusion: Patients presenting with moderate or severe asthma and a duration of symptoms of more than 6 h are more likely to require hospital admission or transfer for further treatment than patients with a shorter duration of symptoms. This has implications for decision making regarding asthma management and disposition in the emergency department.

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Pathogenesis of Exercise-Induced Asthma: Implications for Treatment

Abstract: Although the clinical features of exercise-induced asthma (EIA) have been clearly described, the pathophysiology is incompletely understood. This review addresses some of the current concepts about the pathogenetic mechanisms of EIA and their implications for treatment of this problem.

Cited by 8 publications

References 46 publications

Common triggers of asthma

Common triggers of asthma

An Approach to Pediatric Patients with Chronic Asthma

Patients with a longer duration of symptoms of acute asthma are more likely to require admission to hospital

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