Pathogenesis of Endometriosis

Witz, Craig A.

doi:10.1159/000049425

Cited by 63 publications

(35 citation statements)

References 81 publications

(94 reference statements)

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“…According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue, by inducing an angiogenic phenotype and stimulating the production of proinflammatory, growth, and tissue remodeling factors (Akoum et al 2000, 2002, Taylor et al 2002, Seli & Arici 2003, Wu & Ho 2003, Osteen et al 2004. Furthermore, our and other previous studies showed augmented sensitivity of endometriotic cells to the biological actions of IL-1 (Akoum et al 1995, 2002, Lebovic et al 2000, which may account for their ability to favor their own ectopic growth.…”

Section: Discussionmentioning

confidence: 70%

“…Dual immuofluorescence analysis further identified endothelial cells and inflammatory cells, such as macrophages and T-lymphocytes, as cells markedly expressing IL-1RI in the stroma. These findings are suggestive of a relationship between IL-1RI expression and the implant's activity considering that active endometriotic lesions show a more marked vascularization and leukocyte infiltration (Halme et al 1987, Hill et al 1988, Wiegerinck et al 1993, Kokorine et al 1997, Jones et al 1998, McLaren 2000, Witz 2002, Taylor & Mueller 2004. …”

Section: Discussionmentioning

confidence: 93%

“…Inflammation around and within active endometrial implants, and increased leukocyte infiltration and cytokine secretion as compared to eutopic endometrial tissue have widely been described (Halme et al 1987, Hill et al 1988, Tseng et al 1996, Jolicoeur et al 1998, Jones et al 1998, Witz 2002, Wu & Ho 2003. The secretion of proinflammatory and mitogenic proteins by endometriotic lesions and associated immune cells into the peritoneal environment may contribute to a cascade of events favoring tissue remodeling and invasion of the host tissue, angiogenesis and cell proliferation in the growing lesions and further chemoattraction of leukocytes to these foci of peritoneal inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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The establishment and progression of ectopic endometrial implants are dependent upon their interaction with and responsiveness to the stimuli present in their new environment. According to our and other previous studies, immune cells-derived cytokines, such as IL-1, may alone or in concert with estrogens, enhance the capability of ectopic endometrial cells to implant and develop into the host tissue. In the present study, immunohistochemical and dual immunofluorescence analyses showed that the functional signaling interleukin-1 receptor type 1 (IL-1RI) is expressed in endometriotic tissue, particularly in the glands, and identified endothelial cells, macrophages, and T-lymphocytes as cells having marked expression of IL-1RI. The highest concentrations of IL-1RI protein in endometriotic tissue, as evaluated using histological score (HSCORE) and measured by ELISA, were found in red endometriotic lesions as compared with typical black-blue or white lesions. Western blotting showed a significant increase in the levels of the 50 kDa band, whose apparent molecular weight corresponds to the soluble form of IL-1RI. RT-PCR analysis of IL-1 mRNA levels showed a pattern of expression comparable to that of the protein. Interestingly, IL-1RI expression was more significant in the proliferative than in the secretory phase of the menstrual cycle. Marked expression of IL-1RI, the functional signaling receptor that mediates cell activation by IL-1, in red endometriotic implants, which are highly vascularized and represent the earliest and most active forms of the disease, point to a higher cell receptivity for IL-1 in these lesions, a relationship with the activity of the disease and a possible involvement in the early steps of endometriotic tissue growth and development. Reproduction (2007) 133 265-274

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions

Lawson

Al-Akoum

Maheux³

et al. 2007

Reproduction

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“…Many theories have been proposed to explain this condition as the endometrium implantation theory, the coelomic metaplasia theory, the lymphatic and vascular metastasis theories, the mechanical transplant theory of remnant endometrium in spontaneous or operative delivery, the embryonic rests theory, a recent hypothesis based on the relationship of local immune factors [4].…”

Section: Discussionmentioning

confidence: 99%

Perineal endometriosis: a case report and review of the literature

et al. 2010

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Endometriosis is the presence of endometrial-like tissue outside the uterine cavity, which most commonly affects peritoneal surfaces, ovaries and uterine ligaments. Even it is quite rare, endometriosis may affect the vulva, vagina, rectovaginal septum or perineal region, generally secondary to obstetric or surgical trauma. In this case report, we present a patient with perineal endometriosis in an episiotomy scar. Diagnostic tools used included transvaginal and endorectal ultrasonography (USG), magnetic resonance imaging (MRI) and biopsy. The endometriotic mass was wide-excised together with episiotomy scar. The recovery was uneventful with excellent functional and esthetic results. Six months after operation, woman is asymptomatic. According to the literature and our own experience, wide excision of endometriotic tissue seems to be the best chance of cure with satisfactory functional results and should be recommended.

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“…Cependant l'association exceptionnelle d'une ascite à l'endomé-triose résulte de conditions très particulières favorables au développement des implants superficiels. Il s'agit d'anomalies cellulaires du liquide péritonéal (anomalies des macrophages avec diminution des cellules Natural Killer) et d'une sécrétion élevée de facteurs angiogéniques, de facteurs de croissance, d'adhésion, et des cytokines [8,9]. La physiopathologie de l'épanchement pleural reste également mal élu-cidée.…”

Section: Discussionunclassified