Pathogenesis of degenerative temporomandibular joint arthritides

Milam, Stephen B.

doi:10.1007/s10266-005-0056-7

Cited by 120 publications

(89 citation statements)

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“…The TMJ disc, a dense fibrocartilaginous tissue, distributes stress and aids in lubrication of the joint (Nickel and McLachlan, 1994). It is generally believed that pathological mechanical loading (e.g., sustained jaw clenching or traumatic impact) triggers a cascade of molecular events leading to TMJ disc degeneration and derangement, which are central to many TMJ disorders and pathophysiology (Milam, 2005). However, the molecular mechanism through which biomechanical loading at the tissue level initiates remodeling processes at the cellular level is still poorly understood.…”

Section: Introduction Tmentioning

confidence: 99%

Effect of Mechanical Loading on Electrical Conductivity in Porcine TMJ Discs

et al. 2011

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The objective of this study was to examine the impact of mechanical loading on solute transport in porcine temporomandibular joint (TMJ) discs using the electrical conductivity method. The electrical conductivity, as well as ion diffusivity, of TMJ discs was determined under confined compression with 3 strains in 5 disc regions. The average electrical conductivity over the 5 regions (mean ± SD) at 0% strain was 3.10 ± 0.68 mS/cm, decreased to 2.76 ± 0.58 mS/cm (-11.0%) at 10% strain, and 2.38 ± 0.55 mS/cm (-22.2%) at 20% compressive strain. Correspondingly, the average relative ion diffusivity (mean ± SD) at 0% strain was 0.273 ± 0.055, decreased to 0.253 ± 0.048 (-7.3%) at 10% strain, and 0.231 ± 0.048 (-15.4%) at 20% compressive strain. These results indicated that compressive strain impeded solute transport in the TMJ disc. Furthermore, our results showed that the transport properties of TMJ discs were regiondependent. The electrical conductivity and ion diffusivity in the anterior region were significantly higher than in the posterior region. This regional difference is likely due to the significant differences of tissue hydration between these 2 regions. This study provides important insight into the electrical and solute transport behaviors in TMJ discs under mechanical loading and aids in the understanding of TMJ pathophysiology related to tissue nutrition.

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Section: Introduction Tmentioning

confidence: 99%

Effect of Mechanical Loading on Electrical Conductivity in Porcine TMJ Discs

et al. 2011

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“…Aberrant mechanical loading is one of the etiological factors of TMJ degenerative disease by either trauma or altered mastication 19) . SAMP3 mice are characterized by the degeneration of the bone and cartilage tissue of the TMJ 6) .…”

Section: Discussionmentioning

confidence: 99%

TMJ Degenerative Changes in SAMP3 Mice by Occlusal Disharmony and Aging

Elshawi

Wakamatsu

Iinuma

et al. 2012

J. Hard Tissue Biology.

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Aging and mechanical loading by occlusal disharmony are critical and etiological factors for the onset of temporomandibular joint disorders (TMDs). Senescence-accelerated mouse prone 3 (SAMP3) is one of the animal models for studying age-related degenerative changes of various tissues and organs. To evaluate the influences of both the aging and/or the mechanical loading induced by occlusal disharmony on the SAMP3 TMJ condyle, histological and immunohistochemical analyses were performed.Fifty-five, 4-week-old SAMP3 mice were divided into two groups as an experimental and control. In the experimental group, the maxillary molars were trimmed out from the occlusal plane, which also served as mechanical force loading on the condylar surface. Then the condyles were removed and proceeded for histological and immunohistochemical analysis. The subchondral bone ossification was also evaluated by micro-focusing computed tomography (micro-CT) analysis.The results indicated that induced occlusal disharmony in an aging background promotes TMD, including osteoarthritis (OA) like disease. OA-like TMJ lesions in the SAMP3 mice, accompanied by mandibular condylar cartilage degradation, were characterized by loss of proteoglycans (PGs) and changes of the localization of the extracellular matrix, such as collagen type I, II and MMP13. Changes in the microarchitecture of the condyle were also caused under OA-like lesion. Disrupted Wnt/ -catenin signaling by means of immunohistochemical analysis of -catenin contributes to this irreversible cartilage tissue damage.The present study indicates that the experimentally induced occlusal disharmony (under the age-related background) promotes the TMJ OA accompanied by the alteration to components of the extracellular matrix, and Wnt/ -catenin signaling disorder contributes to these irreversible cartilage tissue damage.

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“…С этим согласуются результаты отечественных авторов, которые также выявили возрастные различия встречаемости указанной патологии: у детей и подростков она колебалась от 14 до 20% [18], у лиц 35-40 лет превы-шала 75% [7,8]. Согласно сведениям Американской сто-матологической ассоциации, проявления ДВНЧС обна-руживаются у 6-12% населения, или примерно у 10 млн взрослых, а затраты на их лечение уступают таковым лишь при злокачественных опухолях [35] За годы изучения ДВНЧС предложено множество те-орий развития данной патологии. Анализируя научно-ис-…”

Section: стоматология 6 2014unclassified