Pathogenesis of COVID-19 and multi-system inflammatory syndrome in children

Shankaralingappa, Arundhathi; Babu, Thirunavukkarasu Arun

doi:10.18203/2349-3291.ijcp20211096

Cited by 8 publications

(10 citation statements)

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“…The pathogenesis of COVID-19 pneumonia in children is similar to that of adults, where viral entry is via angiotensin-converting enzyme receptor 2, the difference being that fewer receptors in children give milder symptoms. In MIS-C, once the viral entry has been established, the early infection activates the macrophages after the T-helper cells causing cytokine release [ 3 ]. One after that develops a hyperimmune state by activating the B-cells causing the production of autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Multisystemic Inflammatory Syndrome

Ebrahim¹,

Moturi²,

Mongare³

et al. 2022

Case Reports in Medicine

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COVID-19 pneumonia in children presents with very mild symptoms through an entity of multisystem inflammatory syndrome and can result in a life-threatening hyperinflammatory condition, with involvement of at least four organ systems and a marked inflammatory state. We present an 18-year-old high school student who presented with a sore throat, macular rash, abdominal pain, diarrhea, fevers, and joint pains. He presented with acute kidney injury and confusion with multiple tests and was eventually diagnosed with multisystem inflammatory syndrome in children (MIS-C).

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Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Multisystemic Inflammatory Syndrome

Ebrahim¹,

Moturi²,

Mongare³

et al. 2022

Case Reports in Medicine

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“…Clinical and laboratory observations suggest many hypotheses of the inflammatory state that occurs in the disease some 2-6 weeks following an acute illness or exposure to SARS-CoV-2. Immune dysregulation in the genesis of MIS-C resulting from an exaggerated hyperimmune response is supported by positive serology and negative PCR testing, while the antibody or T-cell recognition of self-antigens (molecular mimicry) leading to the synthesis of autoantibodies and formation of circulating immune complexes have been proposed [14]. The role of genes in the…”

Section: Sars-cov-2 Pathogenicitymentioning

confidence: 99%

“…clinical expression is suggested by differences in disease incidence in various parts of the world [14].…”

Section: Sars-cov-2 Pathogenesis Human Milk Protection Against Mucosa...mentioning

confidence: 99%

“…The protective mechanisms include reduced expression of receptors that the virus utilizes to enter target cells or the differences in innate and adaptive immunity in this age group compared to adults which contribute to different immune dynamics. The differences in childhood immunity may preserve the pulmonary endothelial barrier and prevent acute respiratory distress syndrome (ARDS) [4,14]. Vitamin D which has antiinflammatory and anti-oxidative properties is noted to be at lower levels in the older age groups and could also contribute to different disease patterns [4]…”

Section: Immunobiology In Children Against Sars-cov-2mentioning

confidence: 99%

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Importance of Human Milk for Health and as Antiviral Immunotherapy - A Narrative Review

Kutty

2022

JAMMR

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Background: Immunological protection against novel mucosal pathogens is crucial to us as our immunity is unable to effectively defend against specific pathogens without previous immune encounters, as experienced in the SARS-CoV-2 pandemic. However, a nursing neonate is protected from many novel infections by exclusive human milk feeding despite having a naïve immune system without much previous pathogen exposure. It is observed that SARS-CoV-2 is not transmitted to the nursing infant through human milk and that natural maternal infections produce specific antibody responses in human milk. Furthermore, maternal vaccination against SARS-CoV-2 may modify some of these responses compared to natural infections. In this setting, it was felt necessary to also explore if early, innate immunity in human milk can protect against SARS-CoV-2.To explore this hypothesis, I reviewed the pathogenic mechanisms of COVID-19 focusing on the methods of viral entry through the human mucosae, infection establishment, immune dysregulation, and disease causation, and integrated these with the early actions by human milk feeding on mucosal infections. I then extrapolated the relevant pathways of human milk immune protection as potentials to protect against SARS-CoV-2. Methods: This was divided into three steps which firstly included a literature search, secondly a stepwise analysis and synthesis of data, and thirdly, an integration of data to form a hypothesis. The first step searched articles in two areas. In the first area, articles included were on the infection and pathogenesis of SARS-CoV-2, and in the second area, articles included were on innate immunity in human milk. In the second step, I analyzed the immunological actions in human milk against mucosal infections, on the whole, and synthesized some of these relevant actions against the pathogenesis of SARS-CoV-2 infections. In the third step, I integrated human milk immune pathways that could interfere with the establishment of SARS-CoV-2 infection, viral invasion, immune dysregulation, and the progression of the disease. Results: Infection by SARS-CoV-2 can theoretically be reduced or mitigated by the effect of early immune constituents in human milk. Human milk feeding may confer protection against all stages of the disease including the establishment of SARS-CoV-2 infection, invasion, and immune dysregulation and these actions may benefit both the individual and the community. Limitations: The multifunctional and dynamic nature in which human milk constituents function in a nursing infant cannot be fully reproduced by studying isolated components under experimental conditions. Even when such factors can theoretically offer protection against the virus, this concept has to be further researched in large cohorts of nursing infants. Conclusion: The role of human milk in preventing infection by SARS-CoV-2 must be explored further and if true, exclusive human milk feeding must be considered another reason for the smaller number of infections observed in children compared to adults in the pandemic. The additional counseling of human milk feeding for protection against novel pathogens, besides its established role in reducing neonatal mortality, would enhance rates of exclusive human milk feeding. General health can be developed and promoted through the potential immunotherapy provided by it.

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“…To the Editor: Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening complication of COVID-19 that may occur during or after recovery from acute infection [ 1 ]. Very limited clinical data are available on MIS-C from India till date [ 2 , 3 ].…”

mentioning

confidence: 99%