Pathogenesis of cervical artery dissections

Brandt, Tobias; Orberk, E.; Weber, R.; Werner, Inge; Busse, O.; Müller, Bárbara; Wigger, Frank; Grau, Armin J.; Grond‐Ginsbach, Caspar; Haußer, Ingrid

doi:10.1212/wnl.57.1.24

Cited by 281 publications

(181 citation statements)

References 43 publications

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“…(3) A skin biopsy from each patient was studied by light and electron microscopy in order to detect connective tissue alterations according to published criteria. 4,10 Microarray data sets were analyzed with different CNV calling algorithms. The Birdsuite algorithm yielded significantly more CNVs calls than PennCNV, with a higher proportion of Birdsuite calls being false positives, as was also found by others.…”

Section: Discussionmentioning

confidence: 99%

“…2 For this study we selected nontraumatic CeAD-patients from the databases of the University hospitals of Basel and Heidelberg who met the following inclusion criteria: (1) written informed consent, (2) Caucasian ethnicity (ie, both parents white Europeans), (3) information about the presence or absence of dermal connective tissue alterations based on criteria published previously 4,10 and (4) availability of sufficient DNA. Seventy-seven patients met the inclusion criteria.…”

Section: Patients and Control Subjectsmentioning

confidence: 99%

“…A genetic predisposition seems likely as CeAD is associated with inherited microscopic and submicroscopic connective tissue alterations in skin biopsy samples from about half of the patients. 3,4 However, the search for mutations in candidate genes in patients with CeAD has yielded disappointing results. 5 Rare copy number variants (CNVs) have a role in the etiology of tetralogy of Fallot, sporadic epilepsy syndromes or autism.…”

Section: Introductionmentioning

confidence: 99%

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Copy number variation in patients with cervical artery dissection

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Section: Patients and Control Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Copy number variation in patients with cervical artery dissection

et al. 2012

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“…The patient did not have signs of connective tissue disease but this diagnosis could not be completely ruled out. Ultrastructural connective tissue abnormalities have been described in skin biopsies of patients with cervical artery dissections who had no other clinical manifestation of a connective tissue disease 28 , alerting to phenotypical heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Progressive cervicocranial arteriopathy with dilatations and stenoses: case report

Conforto

Puglia

Yamamoto

et al. 2004

Arq. Neuro-Psiquiatr.

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-We report the case of a 36 year-old woman who presented occlusion of a basilar artery fusiform aneurysm (FA) associated with pontine infarction, and two episodes of subarachnoid hemorrhage possibly due to arterial dissection. She also had asymptomatic FAs in the right middle cerebral and left internal carotid arteries. Over 5 years, lesions suggestive of fibromuscular dysplasia in the right vertebral artery and occlusion of the left vertebral artery were observed. This combination of lesions emphasizes the possibility of a common pathogenetic mechanism causing different degrees of media disruption in cervicocranial arteries.KEY WORDS: arterial cervicocranial disease, fusiform aneurysms, fibromuscular dysplasia, arterial dissection, subarachnoid hemorrhage. Arteriopatia progressiva com dilatações e estenoses: relato de casoRESUMO -Relatamos o caso de uma doente de 36 anos que apresentou oclusão de um aneurisma fusiforme de artéria basilar associado a infarto pontino e dois episódios de hemorragia subaracnóide provavelmente devido a dissecção arterial. Ela também apresentava aneurismas fusiformes assintomáticos na artéria cerebral média direita e na artéria carótida interna esquerda. Ao longo de 5 anos, lesões compatíveis com displasia fibromuscular foram observadas na artéria vertebral direita, assim como oclusão da artéria vertebral esquerda. Esta combinação de lesões sugere que um mecanismo etiopatogênico comum tenha causado diferentes graus de comprometimento da camada média de artérias cervicocranianas. PALAVRAS-CHAVE: doença arterial cervicocraniana, aneurisma fusiforme, displasia fibromuscular, dissecção arterial, hemorragia meníngea.

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“…A apresentação mais freqüente é o acometimento unilateral da artéria carótida interna 4,5 . A dissecção multiarterial cervical ocorre em até um terço dos casos, eventualmente associada a algum defeito dos componentes do colágeno ou a uma arteriopatia que predisponha à ruptura da camada íntima ou média 6,7 .…”

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Dissecção espontânea cervical carotídea e verbal: estudo de 48 pacientes

Campos

Evaristo

Yamamoto

et al. 2004

Arq. Neuro-Psiquiatr.

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, Milberto Scaff 4 RESUMO -Objetivo: Dada a ausência de estudos de séries brasileiras de pacientes com dissecção arterial cervical espontânea, com o objetivo de descrever os fatores de risco, sintomas precedentes, manifestações clínicas, resultados da investigação, tratamento e evolução. Método: realizamos a análise retrospectiva dos prontuários e laudos radiológicos [angiografia digital(AD), ressonância magnética(RM) e ângio-ressonância(ARM)] dos pacientes com esse diagnóstico atendidos no Serviço de Neurologia do HC/USP entre 1997 e 2003. Resultados: 48 pacientes (24 homens), média de idade 37,9 anos; 26 pacientes com dissecção carotídea (DC) unilateral, 15 com vertebral (DV) unilateral e 7 com multiarterial, todos com déficits neurológicos. Os principais fatores de risco para doença vascular foram hipertensão arterial, tabagismo e dislipidemia. Mais de 80% apresentaram pelo menos um sintoma precedente, na maioria cefaléia têmporo-parietal. Cervicalgia foi referida por 44% dos pacientes com DV e por 3,4% dos com DC. O tempo médio entre o primeiro sintoma e o déficit foi 5,4 dias para as DC e 13,5 para as DV.AD foi o principal método diagnóstico (93%), associado a RM e ARM em 42% dos casos. Em 3 pacientes a RM cervical com supressão de gordura foi isoladamente suficiente. 75% dos pacientes receberam anticoagulação. Dois pacientes fizeram trombólise endovenosa sem complicações. A evolução foi boa, exceto por dois óbitos (DC bilateral). Conclusão: Os resultados são semelhantes aos da literatura, exceto pela baixa freqüência de cervicalgia nos casos de DC e pelo predomínio de cefaléia têmporo-parietal nas dissecções arteriais cervicais. Fatores de risco para doença vascular isquêmica foram frequentes. PALAVRAS-CHAVE: dissecção arterial, artéria carótida interna, artéria vertebral, angiografia, ressonância magnética. Spontaneous cervical carotid and vertebral arteries dissection -Study of 48 patientsABSTRACT -Objective: To report a Brazilian series of spontaneous cervical arterial dissections, risk factors, warning symptoms, clinical manifestations, diagnostic tests, treatment and prognosis. Method: We performed the retrospective analysis of clinical and neuroradiological records (MRI, A-MRI and Angiography) of patients with this diagnosis who were evaluated in a tertiary hospital for the period of 1997-2003. Results: 48 patients (24 men) with median age 37.9 years: 26 patients with unilateral internal carotid dissection (ICAD), 15 with unilateral vertebral artery dissection (VAD) and 7 with multivessel dissections. All patients presented neurological deficits. Hypertension, smoking and dyslipidemia were the main risk factors. More than 80% of patients presented at least one initial symptom, most of them temporoparietal headache. 44% of patients with VAD and only 3.4% of patients with ICAD had neck pain. The median interval between the onset of symptom and the appearance of neurological deficit was 5.4 days for ICAD and 13.5 days for VAD. Five patients with ICAD presented preceding TIA. Angiography was performed in...

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Pathogenesis of cervical artery dissections

Cited by 281 publications

References 43 publications

Copy number variation in patients with cervical artery dissection

Copy number variation in patients with cervical artery dissection

Progressive cervicocranial arteriopathy with dilatations and stenoses: case report

Dissecção espontânea cervical carotídea e verbal: estudo de 48 pacientes

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