Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks

Jian-jun, Zhao; Shi, Ning; Sun, Yan-Gang; Martella, Vito; Nikolin, Veljko; Zhu, Chunsheng; Zhang, Hailing; Hu, Bo; Bai, Xiaoshuan; Yan, Xijun

doi:10.1016/j.antiviral.2015.07.007

Cited by 58 publications

(74 citation statements)

References 49 publications

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“…Post-PPRV eradication, the world's cattle, sheep and goat populations would lack cross-protective immunity to morbillivirus infection. Canine distemper virus (CDV), a virus with an almost global distribution, is capable of causing significant disease in a broad range of hosts, including non-human primates [84,85]. CDV can rapidly adapt to use the human form of the morbillivirus receptor (SLAMF1) in vitro [86], raising concerns about the ease with which these viruses can effectively jump hosts.…”

Section: Examining the Potential For Inter-species (And Zoonotic) Tramentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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Section: Examining the Potential For Inter-species (And Zoonotic) Tramentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

Diop

Njeumi

et al. 2017

Journal of General Virology

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“…A surrogate model based on the study of the Canine distemper virus (CDV)—a closely related morbillivirus that infects a broad range of carnivores including ferrets or dogs—represents an attractive alternative. CDV causes a similar overall pathogenesis in its different hosts, but the disease severity varies from moderate in dogs, to completely lethal in highly susceptible species, such as ferrets and many wild carnivores [4,5]. The clinical signs include fever, often a characteristic rash, diarrhea, nasal discharge, conjunctivitis, and generalized immunosuppression, thereby reproducing the disease spectrum seen in MeV patients (Figure 1).…”

Section: Introductionmentioning

confidence: 97%

Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus

Budaszewski

Messling

2016

Viruses

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Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.

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“…Canine distemper (CD) is a world-wide distributed and highly contagious, febrile and often fatal disease in the wild and domestic carnivores, Mustelidae, Procyonidae, Ursidae and the large Felidae families (Cha et al, 2012;Zhao et al, 2015), and it has recently expanded to nonhuman primates (Bi et al, 2015). The etiological agent is canine distemper virus (CDV).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Canine distemper and Canine parvovirus in pet dogs in Wenzhou, China

Luo

Zhang

2016

IJAR

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Canine distemper virus (CDV) and canine parvovirus (CPV) are two common high morbidity and mortality rates viruses in pet dogs. The current research was designed to investigate the two common diseases in pet dogs in Wenzhou, China. Secretions of eyes, nasal cavities and faeces samples from 2406 pet dogs from various districts of Wenzhou were collected at Wenzhou Vocational College of Science and Technology, Wenzhou, affiliated pet hospital from March of 2010 to December of 2014 and were tested CDV and CPV by commercially available rapid test Kits. Results indicated that the overall prevalence of CDV, CPV, and both viruses infections in pet dogs were observed 28.5% (685); 19.6% (471); and 7.0% (168), respectively in Wenzhou, China.

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Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks

Cited by 58 publications

References 49 publications

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus

Epidemiology of Canine distemper and Canine parvovirus in pet dogs in Wenzhou, China

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