volume 67, issue 1, P101-111 1993
DOI: 10.1128/jvi.67.1.101-111.1993
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Abstract: Cotton rats (Sigmodon hispidus) were inoculated intranasally with 102.0 to 1010.0 PFU of human adenovirus type 5. The virus replicated to a high titer in pulmonary tissues, with the peak titer being proportional to the input dose. The 50% lethal dose was 109-4 PFU. Histopathologic changes were proportional to the infecting inoculum and included the infiltration of interstitial and intra-alveolar areas, moderate damage to bronchiolar epithelium, and cellular infiltration of peribronchiolar and perivascular regi…

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