Pathogenesis, diagnosis and treatment of uterine lipoleiomyoma: A review

Yuan, Yue; Chen, Linjiao; Zhao, Ting C.; Yu, Meiling

doi:10.1016/j.biopha.2021.112013

Cited by 13 publications

(27 citation statements)

References 79 publications

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“…Uterine lipoleiomyomas are a very rare sub-entity of uterine leiomyomas, in which the literature reported its incidence to be 0.03% to 0.2% in 1978 [ 3 ]. However, the stated results of a recent study conducted in 2014 reported a higher incidence of 2.9% [ 5 ]. The mentioned neoplasm is recognized by the presence of abundant and mature adipocytes interspersed in uterine smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, its pathogenesis remains uncertain, however, multiple hypotheses have been proposed. This includes fatty infiltration, degeneration, the iatrogenic introduction of adipose tissue to the myometrium, metaplastic transformation of uterine smooth muscle cells into adipose cells, in addition to the transformation of undifferentiated mesenchymal cells [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical symptoms are variant and size-dependent. While most patients are asymptomatic, some may complain of pelvic pain, abnormal uterine bleeding, urinary frequency, and constipation [ 2 , 5 ]. Radiological imaging is of paramount importance for the detection of this tumor, in which the pelvic US may reveal a well-demarcated, hyperechoic lesion surrounded by a hypoechogenic rim [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lipoleiomyoma is a condition of favorable prognosis, and can rarely progress to leiomyosarcoma. Furthermore, treatment protocols are consistent with those of uterine leiomyomas, and treatment of asymptomatic patients is not recommended [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…While most patients are asymptomatic, some may complain of pelvic pain, abnormal uterine bleeding, urinary frequency, and constipation [2,5]. Radiological imaging is of paramount importance for the detection of this tumor, in which the pelvic US may reveal a well-demarcated, hyperechoic lesion surrounded by a hypoechogenic rim [5]. A computed tomography (CT) scan will present low attenuation of the fat component, however, it holds the disadvantage of poor representation of uterine anatomy [5,9].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Uterine Lipoleiomyoma: A Case Report and Review of Literature

Alsaif¹,

Alali²,

Elsharkawy³

et al. 2021

Cureus

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Uterine lipoleiomyoma is a rare benign neoplasm that falls under the umbrella of uterine leiomyoma. Upon histological examination, leiomyoma is primarily composed of smooth muscle cells of the uterus. Whereas, lipoleiomyoma reveals a characteristic pattern of mature adipocytes interspersed in uterine smooth muscles. This paper is discussing a case of a 60-year-old postmenopausal grand multiparous woman who presented with postmenopausal bleeding. A primary diagnosis of leiomyoma was made, however, histopathological diagnosis revealed its rare variant, lipoleiomyoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Uterine Lipoleiomyoma: A Case Report and Review of Literature

Alsaif¹,

Alali²,

Elsharkawy³

et al. 2021

Cureus

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Lipoleiomyoma: a potential mimic of an ovarian dermoid cyst on MRI—a case report

El Hassouni,

El Graini,

Sassi

et al. 2024

Journal of Surgical Case Reports

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Uterine lipoleiomyomas are rare variants of uterine leiomyomas which is composed of adipocytes and smooth muscle cells. In this report, we describe the case of a 39-year-old patient who presented with persistent, isolated pelvic pain. Ultrasonography showed an oval, well-defined left ovarian mass. Computed tomography (CT) scanning showed a predominantly-fatty mass with tissular components, no calcifications and heterogeneously enhanced after injection, suggesting initially a mature teratoma. Magnetic resonance imaging (MRI) findings revealed a latero-uterine mass, suggesting the presence of a left ovarian dermoid cyst with a potentially-malignant fleshy component. A subsequent pathology report revealed a lipoleiomyoma with cartilaginous metaplasia. Most notably, despite the fatty nature of the tumour and the use of MRI, the pedunculated appearance of the lipoleiomyoma observed intraoperatively mimicked a dermoid tumour even on imaging. Improved understanding of leiomyoma variants and secondary degenerative changes can help prevent misdiagnosis.

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A case report of pelviscopic resection of lipoleiomyoma originating from the uterine cervix in a postmenopausal woman

Kim

Lee

2022

Medicine

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Rationale: Lipoleiomyoma is a rare neoplasm of the uterus. It is considered a variant of uterine myomas. Its reported incidence varies from 0.03% to 0.2%. Lipoleiomyoma consists of variable proportions of mature lipocytes and smooth muscle cells. These tumors generally occur in asymptomatic obese perimenopausal or postmenopausal women. About 90.7% of lipoleiomyomas arise from the uterine corpus, with only 6.5% arising from the cervix. When it occurs in the cervix, it is difficult to diagnose and treat it. We report an uncommon case of pelviscopic resection of uterine cervical lipoleiomyoma showing continuous growth after menopause. Patient concerns: A 55-year-old postmenopausal woman was diagnosed with 40 mm-sized uterine myoma 4 years ago. The size of the mass increased to 58 mm in the last year. Diagnoses: An ultrasound scan revealed a 58 × 34-mm-sized round hyperechogenic and barely vascularity mass that appeared to have originated on the left side of the uterine cervix. Final pathologic findings showed lipoleiomyoma. Interventions: After admission to the hospital, we performed pelviscopic removal of uterine lipoleiomyoma and both tubes. Microscopic examination revealed a significant amount of fat cells between muscle cells. Outcomes: Surgeries were successful. The patient had been followed up regularly for three years after surgery. She did not experience any complications. She remained disease-free. Lessons: Although lipoleiomyomas mainly occur in postmenopausal women, they can also occur in the uterine cervix. They can increase in size after menopause. They can be removed laparoscopically. If a hyperechoic mass occurred in the uterus after menopause that keeps growing without symptoms, a differential diagnosis of lipoleiomyomas must be performed.

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Pathogenesis, diagnosis and treatment of uterine lipoleiomyoma: A review

Cited by 13 publications

References 79 publications

Uterine Lipoleiomyoma: A Case Report and Review of Literature

Uterine Lipoleiomyoma: A Case Report and Review of Literature

Lipoleiomyoma: a potential mimic of an ovarian dermoid cyst on MRI—a case report

A case report of pelviscopic resection of lipoleiomyoma originating from the uterine cervix in a postmenopausal woman

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