Pathogenesis, diagnosis and therapy of induratio penis plastica (IPP)

Schneider, Harold J.; Rugendorff, E. W.; Röhrborn, C

doi:10.1007/bf02085410

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…This may result from the inevitable accumulated sexual activity that increases the risk of repetitive penile trauma, or from the increased vulnerability of the tunica albuginea [22–24]. The results also confirm that β‐blocker therapy and diabetes seem to be potential risk factors [8,10,26], as the incidence of Peyronie's disease was three times greater in diabetics (18.3% vs 6.0%).…”

Section: Discussionmentioning

confidence: 55%

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The prevalence of Peyronie's disease: results of a large survey

et al. 2001

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Objectives To determine the prevalence of Peyronie's disease, a localized connective tissue disorder of the penile tunica albuginea, the symptoms of which include palpable plaque, painful erections and curvature of the penis, in a large sample of men in Germany. Subjects and methods A standardized questionnaire was sent to 8000 male inhabitants (age range 30±80 years) of the greater Cologne area (< 1.5 million inhabitants). Three questions about the selfdiagnosis of Peyronie's disease were previously assessed for validity on 158 healthy men and 24 patients with con®rmed Peyronie's disease. To optimize the response rate, the questionnaire was mailed three times to all the men. Results The response rate after the third mailing was 55.4% (4432 men); 142 men (3.2%, mean age 57.4 years, SD 13.4) reported the new appearance of a palpable plaque which, from the previous validation, was the most sensitive question and the main symptom of the disease. In men aged 30±39 years only 1.5% reported localized penile induration, compared with 3.0% in those 40±49 and 50±59 years, 4.0% in those 60±69 years and 6.5% of those >70 years old. Newly occurring angulation was reported by 119 of the 142 men (84%) and painful erection by 66 (46.5%). The combination of the three symptoms (plaque, deviation and painful erection) was reported by 46 of the 4432 respondents (1.04%), i.e. 32% of the 142 men with penile induration; 58 of the 142 men (41%) reported erectile dysfunction. Conclusions This is the ®rst large cross-sectional, community-based study to examine the prevalence of Peyronie's disease. Using previously validated questions the prevalence of Peyronie's disease in the sample was 3.2%; this is much higher than indicated in previous reports. A comparably high prevalence is reported for diabetes and urolithiasis, suggesting that this`rare' disease is more widespread than previously thought.

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Section: Discussionmentioning

confidence: 55%

“…The most widely accepted hypothesis is that Peyronie's disease is initiated by trauma to the erect penis, with consecutive aberrant wound healing and scar formation [4–6]. Some authors suggested an infectious aetiology, autoimmune disease or local manifestation of a general fibromatosis [7–10].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of Peyronie's disease: results of a large survey

et al. 2001

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“…Additionally, we can confirm that diabetes seems to be a potential risk factor 8,10,19 as the share of diabetics with Peyronie's disease was three times greater (18.3 vs 6.0%).…”

Section: Epidemiology Of Peyronie's Disease F Sommer Et Almentioning

confidence: 51%

Epidemiology of Peyronie's disease

Sommer¹,

Schwarzer²,

Wassmer

et al. 2002

Int J Impot Res

159

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“…Infection, autoimmune origin, local manifestation of a general fibromatosis and part of generalized arterial disease, have been suggested as probablee causes of PD. [7–10] A family history of PD in 2% of patients and an association with Dupuytren's palmar fibromatosis in 20%, which is a known inherited autosomal dominant disease, appear to suggest that patients may have an inherited predisposition to this disease. [8] In addition to a genetic element, an autoimmune component may be present, as evidenced by the finding of abnormal serologic tests in 785 men with PD[11] and the finding of elevated antielastin antibodies in the sera of men with the disease.…”

Section: Definition Etiology and Prevalencementioning

confidence: 99%

US Imaging in Peyronie's Disease

Kalokairinou¹,

Konstantinidis²,

Domazou³

et al. 2012

Journal of Clinical Imaging Science

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The aim of this study is to assess the role of ultrasound (US) in Peyronie's Disease (PD). PD is a psychologically and physically devastating disorder that manifests in middle-aged men. Fibrous inelastic plaques in the tunica albuginea, result in palpable penile scar in the flaccid condition and cause painful erections and penile deformity, including penile curvature, hinging, narrowing, and shortening of penis. Penile deformity is the most common (52%) first symptom of PD and is present in 94% of affected men. US is the primary imaging modality of choice due to its easy availability, low risk, and ability to image and quantify both calcified and soft tissue elements of PD. US provides identification of smaller and non-palpable lesions and shows the extent of fibrosis. Detection of calcifications within the plaque suggests stabilization of the disease and provides information useful to select patients for appropriate treatment.

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Pathogenesis, diagnosis and therapy of induratio penis plastica (IPP)

Cited by 13 publications

References 7 publications

The prevalence of Peyronie's disease: results of a large survey

The prevalence of Peyronie's disease: results of a large survey

Epidemiology of Peyronie's disease

US Imaging in Peyronie's Disease

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