Pathogenesis, Diagnosis, and Management of Kikuchi-Fujimoto Disease

Deaver, Darcie; Horna, Pedro; Cualing, Hernani; Sokol, Lubomir

doi:10.1177/107327481402100407

Cited by 92 publications

(143 citation statements)

References 63 publications

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“…It was first reported in 1972 by Kikuchi and Fujimoto, independently [2,3]. Following the initial descriptions of KFD in 1972, approximately 740 cases have been reported in the literature [4]. Of those cases, 593 (81%) were adult patients, and male to female ratio was 1:2 in adults, but young boys were more commonly affected than girls (1.4:1) [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Following the initial descriptions of KFD in 1972, approximately 740 cases have been reported in the literature [4]. Of those cases, 593 (81%) were adult patients, and male to female ratio was 1:2 in adults, but young boys were more commonly affected than girls (1.4:1) [4,5]. During the 1990's, researchers noted that women were affected four times more than men by this disease, and this female predominance attracted attention from the science community, however, recent reports from Eastern countries have suggested that the actual ratio is closer to 1:1 [1, [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

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Kikuchi Fujimoto Disease: The First Reported Case in Mongolia

Altangerel,

Khatanbaatar,

Natsagdorj

et al. 2017

Cent. Asian j. Med. Sci.

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Objectives: Kikuchi-Fujimoto Disease (KFD) is a rare, benign condition of necrotising histiocytic lymphadenitis, typically presenting in young women. This report is on the first diagnosed case of KFD in Mongolia. Methods: The patient was a 24-year-old female, who presented with fever, night sweats, rash, and cervical lymphadenopathy. Based on clinical features, histopathology, and immunohistochemistry findings, the diagnosis of KFD was confirmed. Results: Full recovery was achieved using symptomatic treatment. Conclusion: To minimize diagnostic confusion and potentially harmful and unnecessary treatments, we emphasize that clinicians should be aware of this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kikuchi Fujimoto Disease: The First Reported Case in Mongolia

Altangerel,

Khatanbaatar,

Natsagdorj

et al. 2017

Cent. Asian j. Med. Sci.

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“…The incidence of the disease is unknown. 13 It usually presents as localized painful lymphadenopathy, most commonly in the cervical region with associated fever and leukopenia in up to 50% of patients. 11 Kikuchi disease almost always runs a benign course and resolves in several weeks to months.…”

Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

Cervical lymphadenopathies: a diagnostic crisis

2017

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Cervical lymphadenopathy refers to lymphadenopathy of the cervical lymph nodes. The causes are varied, and may be inflammatory, degenerative, infective or neoplastic. The first case presented here is of a 29-year old male presented with h/o recurrent progressive right sided painless swelling in the infraparotid region with cervical lymphadenopathy for past one year. Swelling was 6×6cm, nontender, firm mass. Cervical lymph nodes were palpable. He had raised eosinophil counts and elevated serum IgE levels. Biopsy showed abundant eosinophilic infiltration with microabscess suggestive of Kimura’s disease. Second case reported here is of a 17-year old female patient presented with fever for 3 weeks with cervical lymphadenopathy. The lymph node was 3×2cm, tender and firm. Routine blood investigations showed anemia. Biopsy showed lymph nodes composed of sheets of macrophages with crescent shaped nuclei with areas of necrosis and karyhorrhexis suggestive of Kikuchi’s disease. Kimura’s disease is a relatively uncommon chronic inflammatory benign condition mostly affecting the lymph nodes, subcutaneous tissue and salivary glands of head and neck region. It is seen in males in their second decade of lives. Peripheral eosinophilia, regional lymphadenopathy and elevated serum IgE levels are characteristics of Kimura’s disease. Kikuchi-Fujimoto disease is a benign, idiopathic and self-limited disease. Affects young females between 20-35 years of age. Usually there will be localized painful lymphadenopathy, fever and leukopenia. Kikuchi disease runs a benign course and resolves in several weeks to months. The two cases are presented to make clinicians aware of Kimura’s disease and Kikuchi’s disease as a differential diagnosis of cervical lymphadenopathy and to avoid the diagnostic dilemma both clinically and histopathologically.

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“…2 Less common symptoms include chills, night sweats, weight loss, arthralgia, and cutaneous manifestations. 2,5 Although the amount of weight loss is not mentioned in the literature, our patient had lost a significant amount of weight. This may be explained by lack of appetite due to an inflammatory response and release of cytokines.…”

Section: Case Reportmentioning

confidence: 99%

“…In severe cases, high-dose corticosteroids or hydroxychloroquine have been shown to be effective in rapid resolution of symptoms. 1,2,3,7 Due to its association with connective tissue disorders, patients should be evaluated for simultaneous or subsequent development of SLE. 8…”

Section: Case Reportmentioning

confidence: 99%

Kikuchi-Fujimoto Disease: Unusual Presentation of Rare Disease

Reddy

Day

et al. 2016

Clinics and Practice

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Kikuchi-Fujimoto disease (KFD) is a rare, benign disorder that typically follows a selflimiting natural course and was initially described in young females of Asian descent. Its clinical presentation may mimic lymphoproliferative disorders, connective tissue disorders, and chronic infections. This often leads to misdiagnosis and inappropriate treatment. The exact cause of this condition remains unknown although autoimmune processes and certain infectious agents have been associated with the disease. The diagnosis of KFD is made histopathologically. Treatment is supportive and long-term follow-up is recommended due to increased risk of future development of systemic lupus erythematosus. Here we are presenting a case of a patient with an unusual presentation of KFD.

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Pathogenesis, Diagnosis, and Management of Kikuchi-Fujimoto Disease

Cited by 92 publications

References 63 publications

Kikuchi Fujimoto Disease: The First Reported Case in Mongolia

Kikuchi Fujimoto Disease: The First Reported Case in Mongolia

Cervical lymphadenopathies: a diagnostic crisis

Kikuchi-Fujimoto Disease: Unusual Presentation of Rare Disease

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