Pathogenesis and Management of Buerger’s Disease

Abstract

Buerger's disease or thromboangiitis obliterans causes pain, ulceration, or gangrene in the lower or upper extremity. It is associated with chronic cigarette smoking and is believed to be an immune mediated vasculitis. The pathogenesis is still unknown but recent postulate of its association with odontal bacteria has generated much renewed interest. Despite its recognition more than a century ago, little progress has been made in its treatment. Until the pathogenesis is elucidated, abstinence from cigarette is the only effective therapy.

Thromboangiitis obliterans (Buerger's disease)

“…However, the usefulness of surgical sympathectomy seems to be dependent on smoking cessation [35] , [36] , and its role in Buerger's remains controversial because there are no long term data to affirm its benefits [37] . Spinal Cord Stimulation …”

Stem Cell Therapies in Peripheral Vascular Diseases — Current Status

“…15,16 Thromboangiitis obliterans, or Buerger's disease is a non-atherosclerotic segmental inflammatory disease characterized by the presence of thrombosis in the small and medium arterial vasculature, affecting mainly young subjects with a positive history of chronic tobacco use, with frequent distal upper limb involvement, but it can also affect the lower limbs, leading to severe ischemic pain, gangrene of the extremities, and culminating with limb amputation. 17 Mesenteric artery disease is often undiagnosed in clinical practice, and it causes approximately 5% of all acute intestinal ischemic events. 13 The coeliac trunk is more often affected than the superior mesenteric artery, as it was shown by a study on a population undergoing cardiac catheterization, in which the prevalence of mesenteric artery disease was 14%, out of which 11% was located in the coeliac trunk.…”

Thromboangitis obliterans agyi manifesztációja

“…A betegség kezelésében a legfontosabb tényező a dohányzás abbahagyása, amely a betegség progresszióját a legtöbb esetben megállítja, időnként az érfalkárosodás regressziójáról is beszámoltak [5,15]. Betegünk példája is ezt támasztja alá, mivel a dohányzás abbahagyása után az alsó végtagi betegsége nem romlott, viszont a dohányzás újrakezdését követően jelentkezett az agyi manifesztáció.…”