Pathogenesis and Diagnosis of Genitourinary Cancer

Guo, Charles C.; Shen, Steven S.; Ro, Jae Y.

doi:10.3390/cancers13020347

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…As research continues to uncover the complexities of bladder cancer at the molecular level, the potential for tailored precision therapies becomes increasingly promising. The identification of molecular subtypes opens new avenues for personalized treatment pathways, offering renewed hope for individuals battling this clinically complex malignancy [21]. Bladder cancer manifests across a broad clinical spectrum, encompassing early-stage urothelial bladder cancer and advanced urothelial bladder cancer, each with distinct biological behaviors, treatment paradigms, and prognostic implications.…”

Section: The Importance Of Genomic Profiling In Urological Tumorsmentioning

confidence: 99%

Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

Inayat,

Tariq,

Bashir

et al. 2024

ann urol oncol

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Urologic cancers, with bladder cancer as a pivotal subtype, pose substantial challenges to global health, necessitating a profound understanding of their molecular underpinnings. This article explores recent genomic research, with a focus on transitional cell carcinoma, the primary histological form of transitional cell carcinoma, aiming to elucidate the intricate molecular processes that underlie the onset and advancement of disease. Leveraging advanced genomic and transcriptomic analyses such as next-generation sequencing (NGS) and molecular subtyping techniques, this review delves into the diverse genetic and molecular subtypes inherent in bladder cancer. It emphasizes the critical role of molecular subtyping in guiding treatment decisions and refining patient stratification for precision medicine approaches. Furthermore, the review examines emerging diagnostic biomarkers such as methylation markers and single nucleotide polymorphism (SNP) sites, highlighting their potential in enabling early detection and targeted therapies. Their integration promises to enhance diagnostic accuracy and therapeutic monitoring in bladder cancer patients. Collaboration among multidisciplinary teams comprising clinicians, researchers, and bioinformaticians is paramount for unraveling the molecular complexities of urologic cancers and advancing personalized cancer care. This thorough review seeks to offer a detailed examination of the existing understanding on urologic oncology, offering valuable insights into the molecular intricacies of urothelial carcinoma and while also laying the groundwork for future research directions aimed at optimizing patient outcomes globally.

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Section: The Importance Of Genomic Profiling In Urological Tumorsmentioning

confidence: 99%

Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

Inayat,

Tariq,

Bashir

et al. 2024

ann urol oncol

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Section: Introductionmentioning

confidence: 99%

“…Genitourinary cancers include cancers of the urinary system, as well as the reproductive tract [1]. Kidney, bladder, and prostate cancers are the most common genitourinary cancers posing significant health burden [1][2][3]. Between 1990 and 2019, the global incidence of kidney cancer increased by 155%, bladder cancer by 123%, and prostate cancer by 169% [2].…”

Section: Introductionmentioning

confidence: 99%

Awareness of Genitourinary Cancers Risk Factors—A 2024 Population-Based Cross-Sectional Study in Poland

Moczeniat,

Jankowski,

Duda-Zalewska

et al. 2024

Int J Public Health

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ObjectiveThis study aimed to assess the awareness of genitourinary cancers risk factors among adults in Poland and to identify factors associated with public awareness of risk factors for genitourinary cancers.MethodsThis cross-sectional survey was carried out between 1 and 4 March 2024 in a nationwide sample of 2,165 adults in Poland. Quota sampling was used. Data were collected using computer-assisted web interview (CAWI) method.ResultsRegardless of the type of cancer (kidney, bladder, or prostate cancer), a family history of cancer was the most recognized risk factor indicated by over half of respondents. Over one-third were aware that chemical exposure increases the risk for bladder cancer (39.4%) or prostate cancer (34.2%). Smoking was recognized as a risk factor for kidney cancer by 40.6% of respondents. Female gender, having higher education, being occupationally active and the presence of chronic diseases were the most important factors (p < 0.05) associated with a higher level of awareness of genitourinary cancers risk factors.ConclusionThis study revealed gaps in public awareness of genitourinary cancers risk factors among adults in Poland, especially lifestyle-related and workplace-related risk factors.

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“…Genitourinary (GU) cancers, among the most common malignant diseases in men, 1 are a collection of urinary and reproductive system cancers, mainly including prostate cancer (PC), bladder cancer (BC) and kidney cancer with high incidence. PC and BC respectively rank as the second and sixth most common cancer for men in 2020.…”

mentioning

confidence: 99%

Rapid screening for genitourinary cancers: mass spectrometry-based metabolic fingerprinting of urine

Wang

Fan

et al. 2022

Chem. Commun.

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Pathogenesis and Diagnosis of Genitourinary Cancer

Abstract: Genitourinary (GU) cancers are among the most common malignant diseases in men [...]

Cited by 7 publications

References 18 publications

Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

Awareness of Genitourinary Cancers Risk Factors—A 2024 Population-Based Cross-Sectional Study in Poland

Rapid screening for genitourinary cancers: mass spectrometry-based metabolic fingerprinting of urine

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