Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

Valent, Peter; Gleich, Gerald J.; Reiter, Andreas; Roufosse, Florence; Weller, Peter F.; Hellmann, Andrzej; Metzgeroth, Georgia; Leiferman, Kristin M.; Arock, Michel; Sotlar, Karl; Butterfield, Joseph H.; Cerny-Reiterer, Sabine; Mayerhofer, Matthias; Vandenberghe, Peter; Haferlach, Torsten; Bochner, Bruce S.; Gotlib, Jason; Horny, Hans‐Peter; Simon, Hans‐Uwe; Klion, Amy D.

doi:10.1586/ehm.11.81

Cited by 145 publications

(173 citation statements)

References 172 publications

(143 reference statements)

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“…Blood eosinophilia, traditionally defined for use in clinical practice as an eosinophil count of 0.5 3 10 9 /l, is encountered in all areas of medicine and in both primary and secondary care. The degree of blood eosinophilia may be arbitrarily categorized as mild (from 0.5 3 10 9 /l and up to 1.5 3 10 9 /l), moderate (from 1.5 3 10 9 /l and up to 5.0 3 10 9 /l) and severe (from 5.0 3 10 9 /l) and may arise from either clonal intrinsic disorders or from reactive extrinsic conditions [2][3][4]. Reactive causes account for the vast majority of cases.…”

Section: Introductionmentioning

confidence: 99%

“…A plethora of distinct disease entities with concomitant eosinophilia has been known for many years, whereas the primary eosinophilic conditions were not introduced until 1968 [1,5,6]. Advances in cytogenetic, and in particular molecular techniques, have recently identified specific lymphoid and myeloid neoplasms with eosinophilia, hereby categorizing clonal markers in these entities [3,4,7]. For the prognostic evaluation and management of patients presenting with eosinophilia it is important to identify both the many patients with reactive eosinophilia and those patients with the rarer specific clonal diseases.…”

Section: Introductionmentioning

confidence: 99%

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Association of the blood eosinophil count with hematological malignancies and mortality

et al. 2015

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Blood eosinophilia (≥0.5 × 109/l) may be an early sign of hematological malignancy. We investigated associations between levels of blood eosinophils and risks of hematological malignancies and mortality in order to provide clinically derived cut‐offs for referral to specialist hematology care. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count encompassing the eosinophil count during 2000–2007 and matched these laboratory data with Danish nationwide health registers. We used multivariable logistic regression to calculate odds ratios (ORs) for the 4‐year incidences of hematological malignancies and mortality between the eosinophil counts and a reference count of 0.16 × 109/l which was the median eosinophil count in our data. Risks of hematological malignancies and mortality increased above the median eosinophil count. At the 99th percentile, corresponding to an eosinophil count of 0.75 × 109/l, risks of hematological malignancies were increased more than twofold with OR (95% C.I.) of 2.39 (1.91–2.99). Interestingly, risks reached a plateau around an eosinophil count of 1.0 × 109/l. Risks also increased when the eosinophil count approached zero. Here, counts associated relatively more with acute myeloid leukemia and myelodysplastic syndromes whereas counts above 0.16 × 109/l associated more with myeloproliferative neoplasms. Eosinophil counts associate with hematological malignancies and mortality even below the definition of eosinophilia. The observed plateau of risks around 1.0 × 109/l is important for physicians encountering patients with eosinophilia since even mild‐to‐moderate eosinophilia according to traditional definitions confers maximally increased risks of subsequent/subclinical hematological malignancy. Am. J. Hematol. 90:225–229, 2015. © 2014 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of the blood eosinophil count with hematological malignancies and mortality

et al. 2015

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“…Rare cases of eosinophilia are classified as primary or non-reactive and arise from an autonomous cell production, caused by clonal disorders of lymphoid or myeloid origin. A residual small group of patients are termed idiopathic because the suspected clonal origin is missing [3][4][5]. Irrespective of the cause of eosinophilia, activation of eosinophils may cause a diverse organ involvement [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…A residual small group of patients are termed idiopathic because the suspected clonal origin is missing [3][4][5]. Irrespective of the cause of eosinophilia, activation of eosinophils may cause a diverse organ involvement [3,5,6]. Thus, blood eosinophilia may arise from intrinsic eosinophilic disorders caused by cytogenetic mechanisms or extrinsic eosinophilic reactions caused by cytokines [3][4][5]7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Irrespective of the cause of eosinophilia, activation of eosinophils may cause a diverse organ involvement [3,5,6]. Thus, blood eosinophilia may arise from intrinsic eosinophilic disorders caused by cytogenetic mechanisms or extrinsic eosinophilic reactions caused by cytokines [3][4][5]7,8]. Hodgkin's lymphoma (HL) is a classic example of a hematologic, extrinsic disorder accompanied by blood eosinophilia in about 15% of cases.…”

Section: Introductionmentioning

confidence: 99%

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Eosinophilia in routine blood samples and the subsequent risk of hematological malignancies and death

et al. 2013

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Eosinophilia may represent an early paraclinical sign of hematological malignant disease, but no reports exist on its predictive value for hematological malignancies. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count (DIFF) encompassing the eosinophil count during 2000-2007. From these, one DIFF was randomly chosen and categorized according to no (<0.5 3 10 9 /L), mild (0.5-1.0 3 10 9 /L) or severe (1.0 3 10 9 /L) eosinophilia. From the Danish Cancer Registry and the Danish Civil Registration System, we ascertained hematological malignancies and death within 3 years following the DIFF. Using multivariable logistic regression odds ratios (ORs) were calculated and adjusted for previous eosinophilia in a DIFF, sex, age, year, month, C-reactive protein, previous cancer, and comorbidity. ORs for developing Hodgkin's lymphoma (HL) was significantly increased in individuals exhibiting severe eosinophilia, OR 5 9.09 (C.I. 2.77-29.84), P 5 0.0003. The association with classical myeloproliferative neoplasms (cMPNs) showed an increasing risk with OR 5 1.65 (1.04-2.61) P 5 0.0322 and OR 5 3.87 (1.67-8.96) P 5 0.0016 for mild and severe eosinophilia. Eosinophilia was in a similar fashion associated with chronic lymphatic leukemia (CLL), OR 5 2.57 (1.50-4.43), P 5 0.0006 and OR 5 5.00 (1.57-15.94), P 5 0.0065, and all-cause death, OR of 1.16 (1.09-1.24), P < 0.0001 and 1.60 (1.35-1.91), P < 0.0001. We confirm associations between eosinophilia and HL and cMPNs, and in addition for the first time demonstrate a dose-dependent association between eosinophilia and CLL as well as death. Unexplained eosinophilia should prompt clinicians to consider conditions where early diagnosis may improve prognosis. Am.

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A 52-Year-Old With Painful Fingertips

Oka,

Sumitomo,

Ohmura

2023

JAMA

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Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field

Cited by 145 publications

References 172 publications

Association of the blood eosinophil count with hematological malignancies and mortality

Association of the blood eosinophil count with hematological malignancies and mortality

Eosinophilia in routine blood samples and the subsequent risk of hematological malignancies and death

A 52-Year-Old With Painful Fingertips

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