Pathogen transcriptional profile in nasopharyngeal aspirates of children with acute respiratory tract infection

Fukutani, Kiyoshi F.; Nascimento‐Carvalho, Cristiana M.; Gucht, Winke Van der; Khouri, Ricardo; Dierckx, Tim; Ranst, Marc Van; Houspie, Lieselot; Bouzas, Maiara L.; Oliveira, Juliana R.; Barral, Aldina; Weyenbergh, Johan Van; Oliveira, Camila I. de

doi:10.1016/j.jcv.2015.06.005

Cited by 13 publications

(14 citation statements)

References 21 publications

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“…Whether these approaches can work against mixed infections is a pressing question. Aspiration of bacteria from the diverse flora of the upper airway or gastrointestinal tract into the smaller airways of the lower lung can result in life-threatening bacterial pneumonias, often involving two or more bacterial species (33)(34)(35)(36). Epidemiologic studies identified a strong correlation between S. aureus colonization in the upper airway and onset of VAP, and a transition from S. aureus to P. aeruginosa as the primary pathogens in early-to late-onset VAP (37,38).…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

Cohen¹,

Hilliard²,

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

Cohen¹,

Hilliard²,

et al. 2016

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“…Epidemiologic reports show that nasal colonization occurs in approximately 30 to 80% of the overall population and is prevalent among children. This colonization state serves as a reservoir for invasive staphylococcal disease ( 8 , 19 , 24 – 35 ). In most instances, colonizing bacteria form biofilms on nasal tissue, allowing S. aureus to persist by evading host defenses and antibiotic treatment ( 36 ).…”

Section: Introductionmentioning

confidence: 99%

Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

Reddinger

Luke-Marshall

Håkansson

et al. 2016

mBio

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Staphylococcus aureus is a ubiquitous opportunistic human pathogen and a major health concern worldwide, causing a wide variety of diseases from mild skin infections to systemic disease. S. aureus is a major source of severe secondary bacterial pneumonia after influenza A virus infection, which causes widespread morbidity and mortality. While the phenomenon of secondary bacterial pneumonia is well established, the mechanisms behind the transition from asymptomatic colonization to invasive staphylococcal disease following viral infection remains unknown. In this report, we have shown that S. aureus biofilms, grown on an upper respiratory epithelial substratum, disperse in response to host physiologic changes related to viral infection, such as febrile range temperatures, exogenous ATP, norepinephrine, and increased glucose. Mice that were colonized with S. aureus and subsequently exposed to these physiologic stimuli or influenza A virus coinfection developed pronounced pneumonia. This study provides novel insight into the transition from colonization to invasive disease, providing a better understanding of the events involved in the pathogenesis of secondary staphylococcal pneumonia.

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“…Another prospective study investigated the nasopharyngeal microbiota in young infants with RSV infections by 16S-RNA sequencing; the authors found that RSV infection was positively associated with H. influenzae and S. pneumoniae , but negatively associated with S. aureus nasopharyngeal colonization [39]. In another study concerning nasopharyngeal aspirates from children with RSV infection aged between 6 months and 2 years, S. aureus was shown to colonize 77% of RSV-infected patients with a positive association between RSV and S. aureus nasopharyngeal carriage [40]. The conflicting data from the two latter studies may be explained by differences in target populations, sampling procedures and/or microbiological methods.…”

Section: Impact Of Viral Infections In the Respiratory Tract On Staphmentioning

confidence: 99%

Staphylococcus aureus colonization and non-influenza respiratory viruses: Interactions and synergism mechanisms

et al. 2018

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Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may increase the S. aureus carriage load in humans and its spread. In children, respiratory syncytial virus infection is associated with S. aureus carriage. The mechanisms by which some non-influenza respiratory viruses predispose host cells to S. aureus superinfection can be summarized in three categories: i) modifying expression levels of cellular patterns involved in S. aureus adhesion and/or internalization, ii) inducing S. aureus invasion of epithelial cells due to the disruption of tight junctions, and iii) decreasing S. aureus clearance by altering the immune response. The comprehension of pathways involved in S. aureus-respiratory virus interactions may help developing new strategies of preventive and curative therapy.

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Pathogen transcriptional profile in nasopharyngeal aspirates of children with acute respiratory tract infection

Cited by 13 publications

References 21 publications

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

Staphylococcus aureus colonization and non-influenza respiratory viruses: Interactions and synergism mechanisms

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