Pathogen-Specific Clustering of Nosocomial Blood Stream Infections in Very Preterm Infants

Reichert, Felix; Piening, Brar; Geffers, Christine; Gastmeier, Petra; Bührer, Christoph; Schwab, Frank J.

doi:10.1542/peds.2015-2860

Cited by 20 publications

(11 citation statements)

References 40 publications

(46 reference statements)

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“…Staphylococcus aureus (S. aureus) is a well-established nosocomial pathogen that causes multiple types of neonatal infections [1,2]. Invasive S. aureus infections in neonates (e.g.…”

Section: Introductionmentioning

confidence: 99%

Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

Slingerland

Vos

Bras

et al. 2020

Antimicrob Resist Infect Control

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Background: Neonatal Staphylococcus aureus (S. aureus) bacteremia is an important cause of morbidity and mortality. In this study, we examined whether methicillin-susceptible S. aureus (MSSA) transmission and genetic makeup contribute to the occurrence of neonatal S. aureus bacteremia. Methods: A retrospective, single-centre study was performed. All patients were included who suffered from S. aureus bacteremia in the neonatal intensive care unit (NICU), Erasmus MC-Sophia, Rotterdam, the Netherlands, between January 2011 and November 2017. Whole-genome sequencing (WGS) was used to characterize the S. aureus isolates, as was also done in comparison to reference genomes. Transmission was considered likely in case of genetically indistinguishable S. aureus isolates. Results: Excluding coagulase-negative staphylococci (CoNS), S. aureus was the most common cause of neonatal bacteremia. Twelve percent (n = 112) of all 926 positive blood cultures from neonates grew S. aureus. Based on core genome multilocus sequence typing (cgMLST), 12 clusters of genetically indistinguishable MSSA isolates were found, containing 33 isolates in total (2-4 isolates per cluster). In seven of these clusters, at least two of the identified MSSA isolates were collected within a time period of one month. Six virulence genes were present in 98-100% of all MSSA isolates. In comparison to S. aureus reference genomes, toxin genes encoding staphylococcal enterotoxin A (sea) and toxic shock syndrome toxin 1 (tsst-1) were present more often in the genomes of bacteremia isolates. Conclusion: Transmission of MSSA is a contributing factor to the occurrence of S. aureus bacteremia in neonates. Sea and tsst-1 might play a role in neonatal S. aureus bacteremia.

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“…Staphylococcus aureus (S. aureus) is a well-established nosocomial pathogen that causes multiple types of neonatal infections [1,2]. Invasive S. aureus infections in neonates (e.g.…”

Section: Introductionmentioning

confidence: 99%

Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

Slingerland

Vos

Bras

et al. 2020

Antimicrob Resist Infect Control

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“…Candida bloodstream infection (BSI) is associated with high mortality and morbitidy rates among critically ill patients 1, 2 . The incidence of candidemia varies from 24 to 32.3 episodes/per 10,000 admissions 1, 3, 4 , and the mortality rate was 22–60% 2–6 .…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of candidemia varies from 24 to 32.3 episodes/per 10,000 admissions 1, 3, 4 , and the mortality rate was 22–60% 2–6 . Recent strategies of antifungal prophylaxis or preemptive therapy for selected high-risk patients account for emergence of fluconazole resistant strains and an increased prevalence of non- albicans Candida species 7–9 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia

Tsai

Hsu

Chu

et al. 2017

Sci Rep

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We aimed to determine the clinical and microbiological characteristics of Candida bloodstream infections in children and the impact of therapeutic strategies on outcomes. All pediatric patients with candidemia from a medical center in Taiwan over a 13-year period (2003–2015) were included and a total of 262 patients with 319 episodes of candidemia were analyzed. Overall susceptibility to fluconazole was 86.1%. Cumulative mortality at 7 and 30 days after the first episode of candidemia was 13.4% and 25.2%, respectively. The overall in-hospital mortality rate was 35.1%. The treatment outcomes did not change over the study period. Multivariate analysis showed that delayed catheter removal (odds ratio [OR], 5.52; 95% confidence interval [CI]: 2.97–10.25), septic shock (OR, 5.49; 95% CI: 2.85–10.57), and breakthrough candidemia (OR, 3.66; 95% CI: 1.43–9.35) were independently associated with clinical treatment failure. In children with candidemia, underlying renal insufficiency and hematological/oncological malignancy, delayed catheter removal, and septic shock at onset were independently associated final in-hospital mortality. Analyzing the subgroup of non-neonatal children did not change the findings. We concluded overall mortality of pediatric candidemia remains high during the past decade. Prompt early catheter removal and aggressive treatment strategy in patients with septic shock would be critical to improve outcomes.

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“…Auch das epidemische Potenzial und die Letalität verschiedener Bakterienspezies unterscheiden sich deutlich. So konnte gezeigt werden, dass bei Anwesenheit eines Frühgeborenen mit Sepsis durch Serratia marcescens und P. aeruginosa das Risiko für andere Frühgeborene der gleichen NIPS, ebenfalls eine LOS mit dem gleichen Erreger zu entwickeln, signifikant erhöht ist [26] und dass die Sepsis mit Koagulase-negativen Staphylokokken, S. aureus und Enterokokken mit einem deutlich geringeren adjustierten Sterblichkeitsrisiko assoziiert ist als die Sepsis mit gramnegativen Erregern [27].…”

Section: Känguru-pflegeunclassified

Prävention nosokomialer Infektionen in der Neonatologie

Petersen¹,

Piening²

2019

Neonatologie Scan

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Pathogen-Specific Clustering of Nosocomial Blood Stream Infections in Very Preterm Infants

Cited by 20 publications

References 40 publications

Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

Whole-genome sequencing to explore nosocomial transmission and virulence in neonatal methicillin-susceptible Staphylococcus aureus bacteremia

Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia

Prävention nosokomialer Infektionen in der Neonatologie

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