Pathogen infection induces specific transgenerational modifications to gene expression and fitness in Caenorhabditis elegans
Phillip Wibisono,
Jingru Sun
Abstract:How pathogen infection in a parental generation affects response in future generations to the same pathogen via epigenetic modifications has been the topic of recent studies. These studies focused on changes attributed to transgenerational epigenetic inheritance and how these changes cause an observable difference in behavior or immune response in a population. However, we questioned if pathogen infection causes hidden epigenetic changes to fitness that are not observable at the population level. Using the nem… Show more
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