Paternity and Testicular Function Among Testicular Cancer Survivors Treated With Two to Four Cycles of Cisplatin-Based Chemotherapy

Infertility with Testicular Cancer

“…There was no differences in LH, testosterone, or sperm counts; however, there was a limited number of patients with semen analysis. 40 In another large study by Brydoy and colleagues, 554 men treated for testicular cancer were evaluated for paternity. They found that high-dose chemotherapy (>850 mg) had the lowest paternity compared with all other types of treatment.…”

Testicular cancer: A narrative review of the role of socioeconomic position from risk to survivorship

“…All of these treatments have varying side effect profiles, including infertility, chronic medical problems such as cardiovascular disease, neurotoxicity, nephrotoxicity, pulmonary toxicity from treatments, and second cancers and psychological problems [78]. Given the excellent survival among TGCT patients, treatment strategies continued to be explored that will reduce the toxicity of treatment while preserving long-term survival [79]. We did not find any studies of long-term side effects of TC treatment and SEP.…”

Regeneration of Spermatogenesis after Testicular Cancer Chemotherapy

“…However, it is not generally known how long it takes to produce sperm again in their semen. Brydøy et al [7] reported that the paternity rate, by natural conception or using ART when sperm reappeared in their semen, was approximately 10% at 5 years in the patient group having received high-dose cisplatin (total cisplatin dose >850 mg), and about 35% in the group with low-dose cisplatin (total cisplatin dose ≤850 mg). It was only 40%, even after 10 years, in the high-dose cisplatin group.…”

“…Thus, we do not have exact data on how long it takes for the full recovery of spermatogenesis or recovery to the level of normal semen parameters. As mentioned above, it apparently can take up to several years [7]. Therefore, couples should understand that such a time span after the initial appearance of sperm in semen may be necessary for complete recovery of spermatogenesis.…”

“…Cisplatin-based chemotherapy, including BEP, has been shown to have long-term deleterious effects on spermatogenesis. Even though most patients recover their spermatogenesis, it may take more than 5 years in some cases to regain the ability to impregnate, and some patients do not recover the capacity at all [7]. …”