Paternal Obesity and Programming of Offspring Health

Fullston, Tod; Shehadeh, Helana; Schjenken, John E.; McPherson, Nicole O.; Robertson, Sarah A.; Zander-Fox, Deirdre; Lane, Michelle

doi:10.1007/978-1-4939-6386-7_6

Cited by 2 publications

(1 citation statement)

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“…Paternal HFD, leading to diet-induced obesity (DIO) in rats 3 – 5 , results in offspring with delayed growth, impaired liver function 6 – 10 , and deviations in social and anxiety-like defensive behavioral responses 11 , epigenetic reprogramming 12 , 13 , and alterations to the gut microbiome 14 , 15 . Recently, paternal diet has been implicated in the development of inter- and transgenerational offspring phenotypes 16 – 18 . While altered maternal investment 11 , 19 – 21 could potentially explain offspring developmental deficits, epigenetic changes to spermatozoa that cause negative outcomes in the paternal lineage have been identified 22 – 29 .…”

Section: Introductionmentioning

confidence: 99%

Effects of paternal high-fat diet and maternal rearing environment on the gut microbiota and behavior

Korgan

Foxx

Hashmi

et al. 2022

Sci Rep

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Exposing a male rat to an obesogenic high-fat diet (HFD) influences attractiveness to potential female mates, the subsequent interaction of female mates with infant offspring, and the development of stress-related behavioral and neural responses in offspring. To examine the stomach and fecal microbiome’s potential roles, fecal samples from 44 offspring and stomach samples from offspring and their fathers were collected and bacterial community composition was studied by 16 small subunit ribosomal RNA (16S rRNA) gene sequencing. Paternal diet (control, high-fat), maternal housing conditions (standard or semi-naturalistic housing), and maternal care (quality of nursing and other maternal behaviors) affected the within-subjects alpha-diversity of the offspring stomach and fecal microbiomes. We provide evidence from beta-diversity analyses that paternal diet and maternal behavior induced community-wide shifts to the adult offspring gut microbiome. Additionally, we show that paternal HFD significantly altered the adult offspring Firmicutes to Bacteroidetes ratio, an indicator of obesogenic potential in the gut microbiome. Additional machine-learning analyses indicated that microbial species driving these differences converged on Bifidobacterium pseudolongum. These results suggest that differences in early-life care induced by paternal diet and maternal care significantly influence the microbiota composition of offspring through the microbiota-gut-brain axis, having implications for adult stress reactivity.

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