2022
DOI: 10.3389/fgene.2022.1068408
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Paternal epigenetic influences on placental health and their impacts on offspring development and disease

Abstract: Our efforts to understand the developmental origins of birth defects and disease have primarily focused on maternal exposures and intrauterine stressors. Recently, research into non-genomic mechanisms of inheritance has led to the recognition that epigenetic factors carried in sperm also significantly impact the health of future generations. However, although researchers have described a range of potential epigenetic signals transmitted through sperm, we have yet to obtain a mechanistic understanding of how th… Show more

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Cited by 12 publications
(4 citation statements)
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References 178 publications
(212 reference statements)
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“…Thus, alterations inherited from fathers to offspring could also be related to placental-mediated effects. 6 Despite the recent advances related to the mechanisms of inheritance related to programing effects, further studies are needed to elucidate these phenomena.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Thus, alterations inherited from fathers to offspring could also be related to placental-mediated effects. 6 Despite the recent advances related to the mechanisms of inheritance related to programing effects, further studies are needed to elucidate these phenomena.…”
Section: Discussionmentioning
confidence: 99%
“…5 In the case of paternal inheritance, less is known in this regard. Still, in the last years, it has been described that besides the paternal effects on the placenta that can condition the maternal environment and, thus, affect the developing organism 6 ; sperm epigenome, including DNA methylation marks, histone’s modifications, and mainly non-coding RNAs, can be transmitted to the zygote and contribute to fertilization, embryo development and have been related to offspring postnatal health. In addition, some studies have shown that paternal exposure to different diets or chemical compounds can affect offspring health.…”
Section: Introductionmentioning
confidence: 99%
“…First, ethnicity is a social concept that can be related to but is fundamentally different from genetic ancestry. Further, if only maternal ethnicity is collected, it ignores the other parent's contribution to the placental genome and epigenome (31). In addition, genetic ancestry is interesting to study in its own right, as it may independently drive DNAme variation and/or confound other interesting associations.…”
Section: Placental Genetic Ancestry Epiphenotype Accurately Captures ...mentioning
confidence: 99%
“…Epigenetic changes, driven by environmental factors and oxidative processes, also play a crucial role as they can be transmitted across generations. 92 These epigenetic modifications are primarily manifested as patterns of DNA methylation, histone modifications, and RNA modifications, 93 and previous research has established connections between such epigenetic changes and male factor infertility, 94,95 as well as with impaired embryo development. 96 Additionally, Xavier et al suggested that epigenetic alterations can potentially lead to mutations in the offspring.…”
Section: Potential Risks Of Transmitting Genetic Mutations and Epigen...mentioning
confidence: 99%