Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Saltzman, Wendy; Harris, Breanna N.; Jong, Trynke R. de; Perea-Rodríguez, Juan Pablo; Horrell, Nathan D.; Zhao, Meng; Andrew, Jacob R.

doi:10.1093/icb/icx047

Cited by 36 publications

(29 citation statements)

References 83 publications

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“…Social monogamy marks the first extension of the mother‐infant bond to other attachments within the family, specifically mating and fathering. Studies on social monogamy utilized several primate species (cotton‐top tamarins, marmosets and lamurs) 147 , and five rodent species, all originating from a single rodent lineage (prairie voles, mandarin voles, California mice, Campbell's dwarf hamsters, and Mongolian gerbils) 148 .…”

Section: The Three Tenets Of Resiliencementioning

confidence: 99%

What is resilience: an affiliative neuroscience approach

2020

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Resilience – a key topic in clinical science and practice – still lacks a clear conceptualization that integrates its evolutionary and human‐specific features, refrains from exclusive focus on fear physiology, incorporates a developmental approach, and, most importantly, is not based on the negation (i.e., absence of symptoms following trauma). Building on the initial condition of mammals, whose brain matures in the context of the mother's body and caregiving behavior, we argue that systems and processes that participate in tuning the brain to the social ecology and adapting to its hardships mark the construct of resilience. These include the oxytocin system, the affiliative brain, and biobehavioral synchrony, all characterized by great flexibility across phylogenesis and ontogenesis. Three core features of resilience are outlined: plasticity, sociality and meaning. Mechanisms of sociality by which coordinated action supports diversity, endurance and adaptation are described across animal evolution. Humans' biobehavioral synchrony matures from maternal attuned behavior in the postpartum to adult‐adult relationships of empathy, perspective‐taking and intimacy, and extends from the mother‐child relationship to other affiliative bonds throughout life, charting a fundamental trajectory in the development of resilience. Findings from three high‐risk cohorts, each tapping a distinct disruption to maternal‐infant bonding (prematurity, maternal depression, and early life stress/trauma), and followed from birth to adolescence/young adulthood, demonstrate how components of the neurobiology of affiliation confer resilience and uniquely shape the social brain.

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Section: The Three Tenets Of Resiliencementioning

confidence: 99%

What is resilience: an affiliative neuroscience approach

2020

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“…In many species, mothers share their caring activities with other members of the group or family. For example, in some species, a male (most commonly the progenitor) also participates in the caring activities . Although paternal behaviour is considered to occur in only 5%‐10% of the species, these percentages could be underestimating the incidence of this behaviour in males.…”

Section: Oxytocin and Parental Behaviour In Reproductive And Nonrepromentioning

confidence: 99%

“…For example, in some species, a male (most commonly the progenitor) also participates in the caring activities . Although paternal behaviour is considered to occur in only 5%‐10% of the species, these percentages could be underestimating the incidence of this behaviour in males. Division of work between mothers and fathers (guarding/defence vs nursing, etc.)…”

Section: Oxytocin and Parental Behaviour In Reproductive And Nonrepromentioning

confidence: 99%

“…The neural basis supporting nonreproductive parental behaviour is mostly like that described earlier in the present review, although the neuroendocrine or cognitive mechanisms underlying those behavioural changes are less well known. However, the evidence suggests that OXT release in specific sites of the brain might also be behind the onset of paternal behaviour and sensitised (repeated exposures) or spontaneous maternal behaviour in naïve animals …”

Section: Oxytocin and Parental Behaviour In Reproductive And Nonrepromentioning

confidence: 99%

“…However, the evidence suggests that OXT release in specific sites of the brain might also be behind the onset of paternal behaviour and sensitised (repeated exposures) or spontaneous maternal behaviour in naïve animals. 78,83,84 For example, CD38 KO sires with CD38 lentivirus infection in the NAc, and treated with s.c. OXT, recovered from the deficit in retrieval behaviour observed in CD38 KO females that were untreated. 83 Interestingly, a recent study in female mice also showed that OXT in the MPOA promoted sensitised-induced parental behaviour.…”

Section: Ox Y To Cin and Parental B Ehaviour In Reproduc Tive And Nmentioning

confidence: 99%

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Role of oxytocin in parental behaviour

Olazábal

2018

J Neuroendocrinology

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Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts in the brain (eg, medial preoptic area, ventral tegmental area, nucleus accumbens) to promote parental behaviour under different reproductive and physiological conditions. OXT appears to accelerate and strengthen the neural process that makes newborns attractive or rewarding. Furthermore, OXT reduces stress/anxiety and might improve mood and well being, resulting in indirect benefits for parents. However, OXT also plays a role in the development of species reproductive and social strategies, making some species or individuals more prone to display caring activities in nonreproductive contexts. There are important differences in the development of the OXT system and its regulation by gonadal hormones that can make individuals or species very different. Those intra- and interspecific differences in the OXT system have been associated with differences in parental behaviour. For example, differences in OXT levels in body fluids and genetic variants for the OXT and OXT receptor genes have been associated with variability in parental mood and behaviour in humans. Thus, OXT has received much attention as a potential therapeutic agent for affective, emotional and behavioural problems. Despite many preliminary studies indicating promising findings, several unknown aspects of the OXT system remain to be addressed before we can achieve a complete understanding of its function in the brain. The enormous interest that this area of study has attracted in the last decade will likely continually contribute to advancing our understanding of the role of OXT in parental behaviour and other behavioural and physiological functions.

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