Paternal cadmium exposure induces glucolipid metabolic reprogramming in offspring mice via PPAR signaling pathway

Zhou, Jiansheng; Zhang, Yanwei; Wang, Xiaofei; Li, Yamin; Song, Junjie; Shao, Jinyou; Su, Ping

doi:10.1016/j.chemosphere.2023.139592

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…In hypoxic environments, the decrease in oxygen concentration leads to an increase in the proportion of ATP produced by animal bodies through glycolysis [ 38 ]. Research has revealed that the PPAR signaling pathway is closely associated with energy production processes, including lipid metabolism and glucose metabolism [ 39 ], indicating that the PPAR signaling pathway also plays a crucial role in the adaptation of Tibetan sheep to high-altitude hypoxia. Furthermore, our analysis of the cardiac proteome of Tibetan sheep showed a significant enrichment of reactive oxygen species metabolic processes in the three comparative groups at different altitudes.…”

Section: Discussionmentioning

confidence: 99%

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

He,

Li,

Zhao

et al. 2023

IJMS

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The Tibetan sheep has an intricate mechanism of adaptation to low oxygen levels, which is influenced by both genetic and environmental factors. The heart plays a crucial role in the adaptation of Tibetan sheep to hypoxia. In the present study, we utilized transcriptomic and proteomic technologies to comprehensively analyze and identify the long non-coding RNAs (lncRNAs), genes, proteins, pathways, and gene ontology (GO) terms associated with hypoxic adaptation in Tibetan sheep at three different altitudes (2500 m, 3500 m, and 4500 m). By integrating the differentially expressed (DE) lncRNA target genes, differentially expressed proteins (DEPs), and differentially expressed genes (DEGs), we were able to identify and characterize the mechanisms underlying hypoxic adaptation in Tibetan sheep. Through this integration, we identified 41 shared genes/proteins, and functional enrichment analyses revealed their close association with lipid metabolism, glycolysis/gluconeogenesis, and angiogenesis. Additionally, significant enrichment was observed in important pathways such as the PPAR signaling pathway, glycolysis/gluconeogenesis, the oxoacid metabolic process, and angiogenesis. Furthermore, the co-expression network of lncRNAs and mRNAs demonstrated that lncRNAs (MSTRG.4748.1, ENSOART00020025894, and ENSOART00020036371) may play a pivotal role in the adaptation of Tibetan sheep to the hypoxic conditions of the plateau. In conclusion, this study expands the existing database of lncRNAs and proteins in Tibetan sheep, and these findings may serve as a reference for the prevention of altitude sickness in humans.

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Section: Discussionmentioning

confidence: 99%

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

He,

Li,

Zhao

et al. 2023

IJMS

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“…Not only that, but maternal Cd exposure is also associated with fetal obesity. In addition, Cd influenced the lipid compound levels of the serum and tissue, such as triglycerides ( TG ), total cholesterol ( TC ), and free fatty acids ( FFA ) ( Zeng et al, 2023 ). A study indicated that the HDL-C and LDL-C levels gradually decreased and increased with increased urinary Cd levels, respectively ( Aja et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Wang,

Zhang,

Ali

et al. 2024

Poultry Science

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SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

Deng,

Fan,

Gao

et al. 2024

Advanced Science

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Cadmium (Cd) is a neurotoxic contaminant that induces cognitive decline similar to that observed in Alzheimer's disease (AD). Autophagic flux dysfunction is attributed to the pathogenesis of AD, and this study aimed to investigate the effect of autophagy on environmental Cd‐induced AD progression and the underlying mechanism. Here, Cd exposure inhibited autophagosome‐lysosome fusion and impaired lysosomal function, leading to defects in autophagic clearance and then to APP accumulation and nerve cell death. Proteomic analysis coupled with Ingenuity Pathway Analysis (IPA) identified SIRT5 as an essential molecular target in Cd‐impaired autophagic flux. Mechanistically, Cd exposure hampered the expression of SIRT5, thus increasing the succinylation of RAB7A at lysine 31 and inhibiting RAB7A activity, which contributed to autophagic flux blockade. Importantly, SIRT5 overexpression led to the restoration of autophagic flux blockade, the alleviation of Aβ deposition and memory deficits, and the desuccinylation of RAB7A in Cd‐exposed FAD4T mice. Additionally, SIRT5 levels decrease mainly in neurons but not in other cell clusters in the brains of AD patients according to single‐nucleus RNA sequencing data from the public dataset GSE188545. This study reveals that SIRT5‐catalysed RAB7A desuccinylation is an essential adaptive mechanism for the amelioration of Cd‐induced autophagic flux blockade and AD‐like pathogenesis.

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Paternal cadmium exposure induces glucolipid metabolic reprogramming in offspring mice via PPAR signaling pathway

Cited by 7 publications

References 52 publications

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

LncRNA and Protein Expression Profiles Reveal Heart Adaptation to High-Altitude Hypoxia in Tibetan Sheep

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

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