Paternal and/or maternal preconception-induced neurobehavioral teratogenicity in animal and human models

Rimawi, Issam; Ornoy, Asher; Yanai, Joseph

doi:10.1016/j.brainresbull.2021.05.026

Cited by 8 publications

(3 citation statements)

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“…Prenatal exposure to insults has and still is extensively investigated, whereas preconception insult exposure received minimal consideration 8 . Consequences of parental preconception insult exposure on the offspring were first investigated in 1915 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Consequences of parental preconception insult exposure on the offspring were first investigated in 1915 9 . However, only recently did this area of research started to gain attention, especially paternal exposure to insults (for review, see 8 ). This is mainly caused by enhanced knowledge of the mechanisms that may mediate deficits in inheritance including histone modifications, sperm RNA transmission, and DNA methylation (for review, see 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…Previous paternal investigations, mostly employing rodent models, studied the deleterious effects of a variety of insults exposure (including therapeutics, ionizing radiation, lifestyle influences, etc.) on the offspring and observed behavioral, biochemical, and/or molecular alterations (for review, see 8 ). However, only few studies considered investigating gene expression alterations in the avian model after paternal insult exposure 26 , and none considered analyzing the whole transcriptome using next generation sequencing techniques.…”

Section: Introductionmentioning

confidence: 99%

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Whole transcriptome analysis in offspring whose fathers were exposed to a developmental insult: a novel avian model

Rimawi,

Yanai,

Turgeman

et al. 2023

Sci Rep

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Although the effects of paternal exposure to insults on the offspring received limited attention in the past, it is currently gaining interest especially after understanding the mechanisms which may mediate such exposure effects. In the current study, the well-controlled avian model (Fayoumi) was utilized to investigate the effects of paternal exposure to the developmental insult, chlorpyrifos on the offspring’s gene expression via mRNA and small RNA sequencing. Numerous mRNA gene expression changes were detected in the offspring after paternal exposure to the developmental insult, especially in genes related to neurogenesis, learning and memory. qPCR analysis of several genes, that were significantly changed in mRNA sequencing, confirmed the results obtained in mRNA sequencing. On the other hand, small RNA sequencing did not identify significant microRNA genes expression changes in the offspring after paternal exposure to the developmental insult. The effects of the paternal exposure were more pronounced in the female offspring compared to the male offspring. The results identified expression alterations in major genes (some of which were pertinent to the functional changes observed in other forms of early developmental exposure) after paternal insult exposure and provided a direction for future studies involving the most affected genes.

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Section: Introductionmentioning

confidence: 99%