Paternal age as a risk factor for schizophrenia: How important is it?

Paternal Age at Birth of First Child and Risk of Schizophrenia

“…It is important to note that in the initial analyses, similar to those in previous studies, our results were in agreement with earlier fi ndings (18). This reassures us that our other fi ndings plausibly would apply to other studies of paternal age and schizophrenia.…”

Older maternal age and child behavioral and cognitive outcomes: a review of the literature

“…These results suggest that there may also be some causal influence of maternal age on offspring cognitive development. Interestingly, recent research has indicated that social class modifies the heritability of intelligence, where higher family socioeconomic status is associated with increased contribution of genetics to intelligence scores (60,61). It is possible that any causal effect of maternal age on offspring cognitive outcomes may be amplified by the increased affluence often associated with families of older mothers.…”

Beyond the first episode: Candidate factors for a risk prediction model of schizophrenia

“…While no precise age at which risk significantly increases can be clearly delineated, 35 years is the lowest cut-off where the OR is always 41 (Wohl & Gorwood, 2007), though a more recent study suggests the risk is only significant in the offspring of men aged 55 years and over (Torrey et al, 2009). A nationwide nested case control study in Sweden demonstrated a similar association with BAD, with a RR of 1.37 in the offspring of men aged 55 years and older compared to the offspring of men aged 20-24 (Frans et al, 2008).…”