Paternal Age and Epilepsy in the Offspring

Vestergaard, Mogens; Mork, Alissa; Madsen, Kathrine Bang; Olsen, Jørn

doi:10.1007/s10654-005-4250-2

Cited by 63 publications

(40 citation statements)

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“…In addition, substantial residual confounding may be important because estimates were not adjusted for prenatal and perinatal complications, psychiatric or neurologic disorders among family members, or parental socioeconomic status, all of which could influence the association. 2,3,7,14 We performed partially and fully adjusted analyses and found confounders influencing the association between childhood epilepsy and febrile seizure and ADHD, but the association cannot solely be explained by these confounding factors.…”

Section: Figurementioning

confidence: 99%

“…4 These risk factors have also been associated with an increased risk of attentiondeficit/hyperactivity disorder (ADHD). 5,6 Other common risk factors include parental age, 7,8 family history, and genetic factors; 9,10 and this scenario has led to a hypothesis of a common pathophysiological link between epilepsy and psychiatric disorders in general, and ADHD in particular. [11][12][13] Febrile seizure is also a common childhood disorder, affecting 2% to 5% of children before 5 years of age.…”

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Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD

et al. 2016

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OBJECTIVES: Epilepsy, febrile seizures, and attention-deficit/hyperactivity disorder (ADHD) are disorders of the central nervous system and share common risk factors. Our goal was to examine the association in a nationwide cohort study with prospective follow-up and adjustment for selected confounders. We hypothesized that epilepsy and febrile seizures were associated with subsequent ADHD. METHODS:A population-based cohort of all children born in Denmark from 1990 through 2007 was followed up until 2012. Incidence rate ratios (IRRs) and 95% confidence intervals (95% CIs) for ADHD were estimated by using Cox regression analysis, comparing children with epilepsy and febrile seizure with those without these disorders, adjusted for socioeconomic and perinatal risk factors, as well as family history of neurologic and psychiatric disorders. RESULTS:A total of 906 379 individuals were followed up for 22 years (∼10 million personyears of observation); 21 079 individuals developed ADHD. Children with epilepsy had a fully adjusted IRR of ADHD of 2.72 (95% CI, 2.53-2.91) compared with children without epilepsy. Similarly, in children with febrile seizure, the fully adjusted IRR of ADHD was 1.28 (95% CI, 1.20-1.35). In individuals with both epilepsy and febrile seizure, the fully adjusted IRR of ADHD was 3.22 (95% CI, 2.72-3.83). CONCLUSIONS:Our findings indicate a strong association between epilepsy in childhood and, to a lesser extent, febrile seizure and subsequent development of ADHD, even after adjusting for socioeconomic and perinatal risk factors, and family history of epilepsy, febrile seizures, or psychiatric disorders. Ms Bertelsen conceptualized and designed the study, conducted the initial analyses, and drafted the initial manuscript; Ms Larsen conducted the initial analyses and critically reviewed the manuscript; Dr Petersen supervised the initial analyses and critically reviewed the manuscript; Dr Christensen conceptualized and designed the study, helped draft the initial manuscript, and critically reviewed the manuscript; Dr Dalsgaard conceptualized and designed the study, helped draft the initial manuscript, and critically reviewed the manuscript; and all authors approved the fi nal manuscript as submitted. WHAT'S KNOWN ON THIS SUBJECT:Several studies have demonstrated an association between seizure disorders and attention-defi cit/hyperactivity disorder in childhood. Genetic and environmental risk factors infl uence this association, but former studies on this subject have been limited by retrospective designs and small sample sizes. WHAT THIS STUDY ADDS:This prospective population-based study found a strong association between childhood epilepsy and febrile seizures and subsequent attention-defi cit/hyperactivity disorder, even after adjusting for perinatal and socioeconomic risk factors, as well as family history of neurologic and psychiatric disorders.by guest on May 9, 2018 http://pediatrics.aappublications.org/ Downloaded from BERTELSEN et alThe population prevalence of epilepsy has been esti...

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Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD

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“…The most replicated studies in this field showed a link between an advanced paternal age and increased risk for bipolar disorder, epilepsy, autistic behaviours and schizophrenia (Thacker 2004;Malaspina et al 2005;Vestergaard et al 2005;Frans et al 2008;Dalman and Allebeck 2002). Most researchers attribute these associations to the accumulation of chromosomal aberrations and mutations during the maturation of germ cells (Liu et al 2011;.…”

Section: Theories and Mechanisms Of Parental Age And Birth Order Effectsmentioning

confidence: 99%

Maternal age, birth order and other early-life factors: a family-level approach to exploring exceptional survival

Jarry

Gagnon²,

Bourbeau³

2014

Populationyearbook

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The literature provides increasing empirical support for the idea that early-life experiences can greatly shape someone's future health and longevity. Besides shared early-life conditions, within-family variation in maternal age at time of childbirth and birth order have been found to be related to later-life survival. In this study, we examine whether there is a persisting effect of maternal age and birth order on survival to age 104 when both variables are considered and adjusted for season of birth and birth spacing. To address potential confounding by unmeasured family-level factors, we apply a case-sibling control analysis. Using data on 273 centenarians born in Quebec in the 1890-1900 period and their siblings, we show that children born to mothers over age 40 are less likely to reach age 104 while third-and fourthborn children are more likely to make this landmark. When examining the effect of maternal age in combination with the effect of birth order, we obtain higher estimates of both maternal age effects and birth order effects, indicating that the measured influence of one is suppressed when the other is not accounted for. We argue that being born early in the sibling row may provide a biological advantage related in part to the quality of the female reproductive system, but this effect may be counterbalanced by the precariousness of the family as a socio-economic unit at the earliest stages of its cycle. No mediation of these effects is seen when including birth spacing and season of birth. However, we find that birth order differences in longevity are most prominent among siblings born to older mothers and in families where the father was a farmer. We discuss other possible social and historical pathways through which maternal age, birth order and season of birth may operate to mould the offspring's longevity.

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“…Nonetheless, children of older fathers are not only more likely to have several diseases of clear genetic cause (Kühnert and Nieschlag, 2004;Lambert et al, 2006), they show also an increased risk for multifactorial diseases such as birth defects (Olshan et al, 1994;McIntosh et al, 1995;Kazaura et al, 2004;Bille et al, 2005;Zhu et al, 2005a, b;Archer et al, 2007;Yang et al, 2007), childhood cancers (Moll et al, 1996;Hemminki et al, 1999;Sharpe et al, 1999;Murray et al, 2002;Yip et al, 2006), prostate cancer (Zhang et al, 1999), breast cancer (controversial) (Colditz et al, 1991;Choi et al, 2005), diabetes mellitus type l (Bingley et al, 2000;Cardwell et al, 2005), multiple sclerosis (Montgomery et al, 2004), some forms of cerebral palsy (Fletcher and Foley, 1993), schizophrenia (Malaspina, 2001), bipolar disorder (Frans et al, 2008), autism (Reichenberg et al, 2006), epilepsy (Vestergaard et al, 2005), Alzheimer disease (Whalley et al, 1995) and lower intelligence quotients (Malaspina et al, 2005;Saha et al, 2009). However, some of the reported associations need to be considered with caution for methodological reasons in the statistical analysis, especially in regard to the validity of the data sources (Kirby, 2007) (Fig.…”

Section: Paternal Age and Outcome Of Offspringmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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Paternal Age and Epilepsy in the Offspring

Cited by 63 publications

References 10 publications

Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD

Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD

Maternal age, birth order and other early-life factors: a family-level approach to exploring exceptional survival

Paternal age and reproduction

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