Patented Herbal Formulations and their Therapeutic Applications

Musthaba, Mohamed; Baboota, Sanjula; Athar, Tanwir; Thajudeen, Kamal Y.; Ahmed, Shamim; Ali, Javed

doi:10.2174/187221110793237538

Cited by 24 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, there are evidence to show that the majority of these herbal medicines have not been as well screened for efficacy and toxicity when compared to their western counterparts [ 1 , 51 ]. As toxicity studies and scientific investigations into these herbal remedies are often expensive [ 52 ], it is now left to the scientific community to investigate some of the claims of the manufacturers of these herbal preparations to verify or refute their claims. This is an important public health service that must not be overlooked if it is really true that academics must contribute to safeguarding the health of our people.…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

Kale

Awodele

2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThe potential harm of medicinal herbs has been recently observed following herbal toxicity studies after ingestion of polyherbal remedies. This was the rationale for the food and drug regulatory agency decision for thorough safety evaluation of herbal medicines. Androgenic, antipyretic, analgesic and anti-inflammatory potentials as well as chemical compositions of extracts of massularia acuminata, terminalia ivorensis, anogeissus leiocarpus and macuna pruriens respectively have been documented. Thus, Bon-santé cleanser® (BSC) is formulated from these medicinal plants with the intention to boost body hormones and energizes the body. Considering the wide usage of BSC, we investigated on its safety in male Wistar rats.MethodsThirty-two male Wistar rats weighing 201.9 ± 7.5 g were grouped into four treatment groups of eight per group. Group I, (control) received distilled water (10 ml/kg). Groups II-IV received 250 mg/kg, 500 mg/kg and 1000 mg/kg of BSC per oral respectively. Each group was treated for sixty days.ResultsAcute toxicity test, in male Wistar albino mice, showed that LD50 was 600 mg/kg via i.p. while 4 g/kg was nonlethal after oral administration in mice. Hepatic and renal biomarker enzymes were unaltered in all rats. Increased in PCV (p <0.05) was observed at 500 mg/kg. BSC modulates antioxidants biomarkers following sub-chronic administration and increased serum Na+ (p >0.05). BSC at 1000 mg/kg caused mild inflammation of the liver and heart but not kidneys histologically.ConclusionsBSC has been found to be relatively safe in Wistar rats. Although, our findings indicate that herbal therapy with BSC should be done with caution as a mild alteration in the liver and heart architectures were observed.

show abstract

Section: Discussionmentioning

confidence: 99%

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

Kale

Awodele

2016

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Although, it is difficult to claim exclusive rights for growing herbs, spices, plants etc, however, this should not dissuade the manufactures from venturing into HMP research since patents can also be granted on the basis of novelty related to processing and formulating HMP, unique compositions and their intended use for a medical purpose. 185 , 186 , 187 , 188 Patents have been granted for HMP based on novel poly herb compositions, dosage forms, establishment of new processes for isolation and standardization of active compounds. 186 …”

Section: Surmounting the Challenges Faced By Botanicalsmentioning

confidence: 99%

“… 185 , 186 , 187 , 188 Patents have been granted for HMP based on novel poly herb compositions, dosage forms, establishment of new processes for isolation and standardization of active compounds. 186 …”

Section: Surmounting the Challenges Faced By Botanicalsmentioning

confidence: 99%

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

Chugh

Bali

Koul

2018

Integrative Medicine Research

View full text Add to dashboard Cite

The use of botanicals for maintaining good health and preventing diseases is undisputed. The claimed health benefits of natural health products and herbal medicines are based on traditional claims, positive results obtained in preclinical studies and early phase clinical trials that are not backed by safety and efficacy evidences approved by regulatory agencies. Although, the popularity of botanicals is growing, health care practitioners of modern medicine seldom recommend their use because of ill equipped database of their safety and potency. This review discusses problems that preclude botanicals from integrating into the mainstream contemporary therapeutics and cues that provide impetus for their realisation.

show abstract

“…Owing to the side effects of the available drugs and cost, many plant-derived natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including the peptic ulcer [19].…”

Section: Paraffin Basementioning

confidence: 99%

Wound Healing and Anti-Ulcerogenic Activity of Gardenia angustifolia Extract in Rats

James¹,

Christopher²,

Berikisu³

et al. 2013

Biochem & Pharmacol

View full text Add to dashboard Cite

Gardenia angustifolia is widely utilized in many parts of Nigeria to manage a wide range of ailments. As part of effort to elucidate its pharmacological activities and hence medicinal potential, wound healing and anti-ulcerogenic properties of the extract was evaluated using experimentally created wound and ulcers in albino rats. Wound healing properties was evaluated using excision wound model, while anti-ulcer activity was studied using ethanol induced ulcer model. Five groups of rats were experimentally wounded at the back area. An area of uniform wound of 7×7 mm using millimeter ruler was excised. The animal groups were topically treated with Gardenia angustifolia gel, wound dressed with leaf, fruit and root gel significantly healed earlier than those treated with paraffin base and povidone iodine (standard). In anti-ulcer studies, rats were orally administered with different doses of the root extract (100, 250 and 500 mg/kg body weight) and positive control group (Omeprazole, 8 mg/kg body weight) for five days. After induction of ulcer using 5 ml/ kg body weight of ethanol, the stomach of the rats was opened, gastric volume and ulcer area were measured. The results indicated that Gardenia angustifolia root extract could prevent ulceration in rats in a dose dependent manner. The acute toxicity study revealed that the plant could be toxic at higher doses. Blood glucose reduction was dose and time dependent. From this study it is evident that G. angustifolia possess anti-ulcer properties and also wound dressed with the root, leaf and fruit gels significantly enhanced the acceleration of wound healing in rats.

show abstract

Patented Herbal Formulations and their Therapeutic Applications

Cited by 24 publications

References 0 publications

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

Safety evaluation of Bon-santé cleanser® polyherbal in male Wistar rats

Integration of botanicals in contemporary medicine: road blocks, checkpoints and go-ahead signals

Wound Healing and Anti-Ulcerogenic Activity of Gardenia angustifolia Extract in Rats

Contact Info

Product

Resources

About