Patent ductus arteriosus in an adult cat with pulmonary hypertension and right-sided congestive heart failure: hemodynamic evaluation and clinical outcome following ductal closure

Matos, José Novo; Hurter, Karin; Bektas, Rima N; Grest, Paula; Glaus, T M

doi:10.1016/j.jvc.2014.06.001

Cited by 15 publications

(17 citation statements)

References 21 publications

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“…Three animals died during or in the immediate post-operative period, but those that survived surgery with follow-up (3) had good long-term survival. but no arteritis or plexiform lesions 12. It could be postulated that reasons for excellent tolerance after PDA closure in this cat and in the animals who survived surgical ligation in our study, are due to reversible pulmonary vascular disease.Treatment targeting secondary polycythemia has been considered the cornerstone of management of dogs with reverse PDA, aiming to maintain the PCV below a threshold of 65% 8.…”

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confidence: 50%

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Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus

Greet¹,

Bode

Dukes‐McEwan

et al. 2021

Veterinary Internal Medicne

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Background: Studies describing the clinical progression of animals with reverse patent ductus arteriosus (PDA) are lacking. Objectives: To describe the signalment, presenting signs, echocardiographic features, and survival in a group of dogs and cats with bidirectional and continuous right-to-left PDA. Animals: Forty-six client-owned animals included, comprising 43 dogs and 3 cats with bidirectional or continuous right-to-left PDA. Methods: Retrospective multicenter study. Medical records and echocardiographic findings reviewed from animals diagnosed with bidirectional or continuous right-toleft PDA. Impact of ductal morphology, spectral Doppler flow profile, PCV, sildenafil treatment at presentation, sildenafil dose, severity of pulmonary hypertension, general anesthesia with or without surgery and the presence of right-sided congestive heart failure (R-CHF) on crude mortality rate were evaluated via Mantel-Cox log rank comparison of Kaplan-Meier survival curves. Univariable and multivariable Cox proportional hazards analysis was performed, and hazard ratio (HR) (95% confidence intervals [CI]) was presented. Results: Hindlimb collapse was the most common presenting sign in dogs (n = 16). Clinical signs in cats were variable. Median survival time was 626 days in dogs (range 1-3628 days). Dogs with R-CHF had a shorter median survival time (58 days vs 1839 days, P = .03). Dogs treated with sildenafil at initial presentation survived longer (1839 days vs 302 days, P = .03), which was the only independent predictor of survival (HR 0.35, CI 0.15-0.86, P = 0.021).

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confidence: 50%

“…Pulmonary hypertension and "shunt reversal" is a relatively uncommon complication, occurring in approximately 1% to 6% of dogs with PDA. 8,10,11 Cats appear to be more vulnerable to the development of PH, 12 with reverse or bidirectional shunting occurring more frequently in this species (15%-17% of cats with PDAs 13,14 ).…”

Section: Introductionmentioning

confidence: 98%

Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus

Greet¹,

Bode

Dukes‐McEwan

et al. 2021

Veterinary Internal Medicne

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“…Conversely, PAH was diagnosed subsequent to PDA closure in another cat, consistent with pulmonary vascular changes. Both histopathological lung changes on biopsy and resolution of PAH following PDA closure have been reported in a single cat (Novo-Matos and others 2014). Survival times were not significantly different between cats with and cats without PAH but interestingly the cats with PAH appeared to live longer (Fig 3).…”

Section: Discussionmentioning

confidence: 93%

Clinical findings and treatment outcomes for cats diagnosed with patent ductus arteriosus in the UK: a retrospective study of 19 cases (2004–2012)

et al. 2016

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Patent ductus arteriosus (PDA) is infrequently reported in cats and represents between 1-7.3 per cent of left to right shunting cardiac congenital anomalies. The objective of this study was to report the presenting complaints, clinical examination findings, diagnostic findings, treatment outcomes and survival times in cats diagnosed with a PDA in the UK. Medical records from three major UK referral centres were searched for cats that were diagnosed with PDA from January 2004 to December 2012. Data obtained for analysis included: signalment, clinical examination findings including murmur characteristics, diagnostic imaging findings, treatment outcomes and survival times. Nineteen cats were included in the analysis. The most common reason for referral was investigation of an incidentally detected heart murmur without clinical signs (13/19; 68 per cent). Pulmonary arterial hypertension (PAH) was diagnosed in seven (37 per cent) cats and those cats with PAH were significantly more likely to present with signs of disease (P=0.004). Median survival time in cats that were diagnosed with PDA and died due to cardiac causes was 898 days (interquartile range 459-1011 days). The median survival time of those cats that had an additional congenital anomaly was significantly shorter to those cats without a congenital anomaly (P=0.008).

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“…PAH associated with congenital left to right shunts) have been previously described in cats, and in some patients may be reversible. For example, ligation of a patent ductus arteriosus in an eight-year-old cat resulted in longterm clinical improvement; lung biopsy at the time of ligation found medial hypertrophy of small pulmonary arterioles without any detectable plexogenic lesions (Novo-Matos et al 2014). Specific factors that precipitate development of plexogenic vascular lesions are largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Plexogenic pulmonary arteriopathy in a cat with non‐restrictive ventricular septal defect and chronic pulmonary hypertension

Russell

Scansen

Himmel

2015

J of Small Animal Practice

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A 10-week-old, male, domestic long-hair cat was medically managed for congenital heart disease over a period of 8 years. Regular clinical examinations, including sequential echocardiography, documented a non-restrictive paramembranous ventricular septal defect, secundum-type atrial septal defect and aortic dextroposition. Pulmonary arterial hypertension was diagnosed by the presence of high-velocity tricuspid regurgitation, bidirectional low velocity flow across the ventricular septal defect, pulmonary arterial dilation and severe right ventricular hypertrophy without evidence of pulmonary outflow tract obstruction. The cat remained clinically stable until it died suddenly at 8 years of age. Histopathology of the lungs found evidence of plexogenic pulmonary arteriopathy. Despite severe pulmonary vascular lesions, other post-mortem evidence of right heart failure was lacking and death was attributed to a fatal cardiac arrhythmia. In this case report of a cat with chronic pulmonary hypertension over 8 years, plexogenic lesions were found on histopathology. The microscopic findings resemble those previously reported in dogs.

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Patent ductus arteriosus in an adult cat with pulmonary hypertension and right-sided congestive heart failure: hemodynamic evaluation and clinical outcome following ductal closure

Cited by 15 publications

References 21 publications

Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus

Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus

Clinical findings and treatment outcomes for cats diagnosed with patent ductus arteriosus in the UK: a retrospective study of 19 cases (2004–2012)

Plexogenic pulmonary arteriopathy in a cat with non‐restrictive ventricular septal defect and chronic pulmonary hypertension

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