“…To decrease the risk of complications in patients with LSD who are using TIVADs for long-term ERT, we recommend following best practices, such as ultrasound guidance to place central venous catheters [ [3] , [4] , [5] , 21 ], experienced surgical team and personnel [ 1 , 5 ], hand hygiene and barrier precautions, and regular examination for thrombus via ultrasounds [ 3 , 22 ] and of skin integrity over TIVAD sites. The major long-term risk for patients with a potentially lifelong requirement for venous access is occlusion of the great veins and thus consideration should be made from the start to avoid this occurring by using specialist teams of surgeons with an interest in vascular access [ 23 ] and the ultrasound-guided percutaneous approach [ 19 , 23 ]. With these measures and careful placement, monitoring, and confirmation of the need for TIVAD, specialists will be equipped to strive for optimal outcomes with ERT with minimal complications from long-term TIVAD use.…”