2022
DOI: 10.21037/tau-22-667
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Patchouli alcohol inhibits GPBAR1-mediated cell proliferation, apoptosis, migration, and invasion in prostate cancer

Abstract: Background: G protein-coupled bile acid receptor 1 (GPBAR1) is a G protein-coupled receptor for bile acids, which is widely expressed in many human tissues. Patchouli alcohol (PA) has been shown to have an anti-cancer effect, including in prostate cancer (PCa). This study sought to confirm the regulatory mechanism of GPBAR1 in the anti-cancer activity of PA in PCa. Methods:The SwissTargetPrediction website (Pro >0) was used to predict the target of PA. The UALCAN and The Cancer Genome Atlas-Prostate cohort was… Show more

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Cited by 2 publications
(1 citation statement)
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“…The components were used as entry points to query their simplified molecular-input line-entry system (SMILES) numbers on PubChem 1 ( 21 ). The SMILES numbers were imported into SwissTargetPrediction 2 to retrieve the targets of each component ( 22 ), and targets with a probability greater than 0 were selected as the study objects ( 23 ) ( Supplementary Table S2 ).…”
Section: Methodsmentioning
confidence: 99%
“…The components were used as entry points to query their simplified molecular-input line-entry system (SMILES) numbers on PubChem 1 ( 21 ). The SMILES numbers were imported into SwissTargetPrediction 2 to retrieve the targets of each component ( 22 ), and targets with a probability greater than 0 were selected as the study objects ( 23 ) ( Supplementary Table S2 ).…”
Section: Methodsmentioning
confidence: 99%