Deep learning is the current de facto state of the art in tomographic imaging. A common approach is to feed the result of a simple inversion, for example the backprojection, to a convolutional neural network (CNN) which then computes the reconstruction. Despite strong results on "in-distribution" test data similar to the training data, backprojection from sparse-view data delocalizes singularities, so these approaches require a large receptive field to perform well. As a consequence, they overfit to certain global structures which leads to poor generalization on out-of-distribution (OOD) samples. Moreover, their memory complexity and training time scale unfavorably with image resolution, making them impractical for application at realistic clinical resolutions, especially in 3D: a standard U-Net requires a substantial 140GB of memory and 2600 seconds per epoch on a research-grade GPU when training on 1024 × 1024 images. In this paper, we introduce GLIMPSE, a local processing neural network for computed tomography which reconstructs a pixel value by feeding only the measurements associated with the neighborhood of the pixel to a simple MLP. While achieving comparable or better performance with successful CNNs like the U-Net on in-distribution test data, GLIMPSE significantly outperforms them on OOD samples while maintaining a memory footprint almost independent of image resolution; 5GB memory suffices to train on 1024 × 1024 images. Further, we built GLIMPSE to be fully differentiable, which enables feats such as recovery of accurate projection angles if they are out of calibration.