Patchable micro/nanodevices interacting with skin

Bai, Wubin; Kuang, Tairong; Chitrakar, Chandani; Yang, Ruiguo; Li, Shulin; Zhu, Donghui; Chang, Lingqian

doi:10.1016/j.bios.2018.09.035

Cited by 48 publications

(43 citation statements)

References 149 publications

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“…Flexible strain sensors, in contrast to metal or semiconductor-based conventional strain sensors, exhibit a superior application potential in a wide array of fields that includes monitoring of sports performance 1 , virtual reality 2 , personal healthcare 3 , human–machine interface 4 , and so on. Their ability to transform mechanical deformation stimuli into electrical shift signals is largely appreciated by researchers as well as industrial guys 5 .…”

Section: Introductionmentioning

confidence: 99%

Graphene/PVA buckypaper for strain sensing application

Mehmood

Mubarak

Khalid

et al. 2020

Sci Rep

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Strain sensors in the form of buckypaper (BP) infiltrated with various polymers are considered a viable option for strain sensor applications such as structural health monitoring and human motion detection. Graphene has outstanding properties in terms of strength, heat and current conduction, optics, and many more. However, graphene in the form of BP has not been considered earlier for strain sensing applications. In this work, graphene-based BP infiltrated with polyvinyl alcohol (PVA) was synthesized by vacuum filtration technique and polymer intercalation. First, Graphene oxide (GO) was prepared via treatment with sulphuric acid and nitric acid. Whereas, to obtain high-quality BP, GO was sonicated in ethanol for 20 min with sonication intensity of 60%. FTIR studies confirmed the oxygenated groups on the surface of GO while the dispersion characteristics were validated using zeta potential analysis. The nanocomposite was synthesized by varying BP and PVA concentrations. Mechanical and electrical properties were measured using a computerized tensile testing machine, two probe method, and hall effect, respectively. The electrical conducting properties of the nanocomposites decreased with increasing PVA content; likewise, electron mobility also decreased while electrical resistance increased. The optimization study reports the highest mechanical properties such as tensile strength, Young’s Modulus, and elongation at break of 200.55 MPa, 6.59 GPa, and 6.79%, respectively. Finally, electrochemical testing in a strain range of ε ~ 4% also testifies superior strain sensing properties of 60 wt% graphene BP/PVA with a demonstration of repeatability, accuracy, and preciseness for five loading and unloading cycles with a gauge factor of 1.33. Thus, results prove the usefulness of the nanocomposite for commercial and industrial applications.

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Section: Introductionmentioning

confidence: 99%

Graphene/PVA buckypaper for strain sensing application

Mehmood

Mubarak

Khalid

et al. 2020

Sci Rep

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“…3D artificial micro/nano scaffolds have already developed for bone regeneration [8,9], load-bearing bone defect repair [10,11] and large osteochondral defects in the articular joints [12]. Autologous chondrocytes-loaded micro/nano b-tricalcium phosphate (b-TCP) bioceramic scaffold has been explored in the repair of osteochondral defects and showed good regeneration behaviors [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment

Kai

Wang

Tao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano scaffolds have been widely developed and explored in the tissue repair of articular joints. In this study, chondrocyte/osteoblast-loaded b-tricalcium phosphate (b-TCP) bioceramic scaffold and chondrocyte-loaded b-TCP bioceramic scaffold were prepared by micromass stem cell culture and bioreactor-based cells-loaded scaffold culture for articular cartilage defect treatment. The results demonstrate chondrocyte and osteoblast can be successfully induced from allogeneic bone marrow stromal cells using micromass stem cell culture. Further, chondrocyte-loaded b-TCP scaffold and osteoblast-loaded b-TCP scaffold can be successfully prepared by bioreactor-based cells-loaded scaffold culture. Finally, the scaffolds are applied for Beagle articular cartilage defect treatment. The relative cartilage regeneration abilities on Beagle femoral trochleae were as follows: Chondrocyte/osteoblast-loaded b-TCP bioceramic scaffold group > chondrocyte-loaded b-TCP bioceramic scaffold group > b-TCP bioceramic scaffold. Therefore, micromass stem cell culture and bioreactor-based cells-loaded scaffold culture can be applied to prepare chondrocyte/osteoblastloaded b-TCP bioceramic scaffold for articular cartilage defect treatment. It suggests allogenic chondrocyte/osteoblast-loaded b-TCP bioceramic scaffold could be potentially used in the treatment of patients with cartilage defects.

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“…In transdermal delivery or cell transfection, microneedles and electroporation have been applied for decades [3]. However, in vivo techniques still face challenges for delivering DNA plasmids among other macromolecular cargo with high efficiency and specificity.…”

Section: Wearable Devices For Single-cell Transfectionmentioning

confidence: 99%

“…By temporarily cracking the cell membrane, cell permeability to macromolecules is increased [66]. This permeabilization can be achieved by several means, including viral vectors, chemical vectors, and physical methods [3,67]. In in vitro conditions, multiple physical approaches, including cell squeezing [68], sonoporation [69], microinjection [70], and optical transfection [71], have been reported.…”

Section: Wearable Electroporation For Single-cell Transfectionmentioning

confidence: 99%

“…The field of wearable electronics (see Glossary) and devices has advanced quickly over the past decade, with a focus on sensing physical and chemical properties and delivering stimulation and/or substances via direct contact with the skin [1][2][3][4]. With the integration of nanomaterials and rapid advancement of fabrication technologies, new devices functioning at the cellular level will lead to improved efficiency, safety, and non-invasiveness [5]. Miniaturizing these new devices to the scale comparable to a single cell could significantly increase the precision of cellular diagnosis and treatment that could not be achieved within bulk environments [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Wearable Devices for Single-Cell Sensing and Transfection

Chang

Wang

Ershad

et al. 2019

Trends in Biotechnology

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Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields. Highlights• Current wearable sensors have allowed for long-term, real-time detection of specific biomarkers directly from patients. • Miniaturized wearable biosensors with sensing elements interacting with skin or organs can capture target molecules from single cells, which results in significantly increased sensitivity, responding time, and precision. • Emerging wearable devices based on novel nanomaterials or nanofabricationshow potential for single-cell detection in cancer cell screening, cardiomyocyte detection, and optogenetics. • Transdermal delivery devices have been scaled down to the micro-and/or nanoscale, and their applications have extended to wide selections of natural molecules and bioengineered molecules. • Emerging nanodevices show unique capabilities in precise single-cell gene transfection in vivo, with improved delivery efficiency, safety, and dose controllability.RH Segoe Text 8 pt SC

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Patchable micro/nanodevices interacting with skin

Cited by 48 publications

References 149 publications

Graphene/PVA buckypaper for strain sensing application

Graphene/PVA buckypaper for strain sensing application

Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment

Wearable Devices for Single-Cell Sensing and Transfection

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