Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes (biosheets)

Satake, Ryosuke; Komura, Makoto; Komura, Hiroko; Kodaka, Tetsuro; Terawaki, Kan; Ikebukuro, Kenichi; Komuro, Hiroaki; Yonekawa, Hironobu; Hoshi, Kazuto; Takato, Tsuyoshi; Nakayama, Yasuhide

doi:10.1016/j.jpedsurg.2015.10.068

Cited by 29 publications

(16 citation statements)

References 18 publications

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“…And after getting preclinical studies and satisfactory verification from two formal clinical trials of partial laryngeal and tracheal replacement, porcine decellularized scaffolds seeded with human cells use started from 2015 for tissue engineering and preclinical study (Ansari et al, ; Liu et al, ). In another study, freeze‐dried collagenous biosheets implanted in rabbit model showed hyaline cartilage and mucosal layer regeneration (Komura et al, ; Satake et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 97%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 97%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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“…We have previously found that Biosheets produced by iBTA technology can recruit tissue stem cells from native tissue, and that these stem cells then mature and undergo proliferation (17). Biosheets were reconstructed in a manner analogous to native tissue, such as cornea, trachea, diaphragm, and esophagus (17,(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Urinary bladder reconstruction using autologous collagenous connective tissue membrane “Biosheet” induced by in-body tissue architecture

Iimori

Naito

Iwai

et al. 2019

Preprint

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Background: Tissue engineering technology has the potential for bladder reconstruction without complications. We have previously developed autologous collagenous prosthetic tissues using in-body tissue architecture (iBTA). This is a cell-free tissue engineering technology that can produce autologous implantable tissues be a desired shape by simple subcutaneous embedding of a specially designed mold. Grafts formed by iBTA can be made in any shape and form, including sheet-shaped tissues (Biosheet). In this study, we evaluated the efficacy and safety of autologous Biosheet as bladder repair material in a canine bladder defect model. Methods: We studied four healthy adult beagles (1-2 years old, 9.3-9.9 kg). Autologous Biosheets were prepared by embedding specially designed molds into subcutaneous pouches in the beagles. Eight weeks after implantation, the molds were extracted, and collagenous connective tissues surrounding the molds were harvested as autologous Biosheet. The urinary bladder wall was excised (2 cm × 2 cm) and autologous Biosheets were sutured to the cut edge of the native bladder using a simple continuous suture pattern. The efficacy of implantation of the Biosheets was evaluated by physical examination, blood tests, abdominal ultrasound, urinalysis, and urography, at 0, 1, 3, 7, 14, 28, 56, and 84 days after the implantation. The Biosheets were extracted at 28 days (n=1) and 84 days (n=3) after implantation. Results: No side-effects were observed during follow-up. No disruption of the sheet or any urinary leakage into the peritoneal cavity was observed. Histological analysis revealed α-SMA-positive muscle fibers at the margin of the Biosheets, indicating regeneration of the urinary bladder tissue. Conclusion: This is the first report evaluating the efficacy and safety of iBTA-induced autologous “Biosheets” as a bladder repair material in a canine model. In summary, autologous Biosheets could be useful biomaterials for urological reconstruction.

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“…Robotically assisted bilateral bronchoplasty, bioresorbable 3D airway stents, and tracheal cartilage regeneration techniques are also under investigation. [35][36][37] Conclusion ECAC is characterized by nonspecific symptom profile that may overlap with other more common diseases such as COPD and asthma. This often lead to delayed or misdiagnosis.…”

Section: Novel Therapiesmentioning

confidence: 99%

Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment

Kheir

Majid

2018

Semin Respir Crit Care Med

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Excessive central airway collapse (ECAC) is characterized by excessive narrowing of the airway lumen during exhalation leading to dyspnea, cough, mucostasis, recurrent respiratory infections, and poor quality of life. Tracheobronchomalacia and excessive dynamic airway collapse are heterogeneous entities of ECAC and are characterized by a diverse nonspecific symptom profile. Although the pathophysiology of airway mechanics as well as morphology in both entities is different, current evidence so far shows no practical benefit in making such distinction since both have similar symptoms and the diagnostic and therapeutic work-ups are the same. The diagnosis of ECAC should be based on dynamic flexible bronchoscopy and/or dynamic computed tomography scan as well as clinical symptoms that are not fully explained by other lung diseases. Initial treatment of symptomatic ECAC includes treatment of coexisting conditions (such as chronic obstructive pulmonary disease, asthma, gastroesophageal reflux disease, and vocal cord dysfunction) and supportive treatment of dynamic central airway collapse (antibiotics for respiratory infections, aggressive therapy, pulmonary physiotherapy, pulmonary rehabilitation, and continuous positive airway pressure). A short-term stent trial in selected patients with severe symptomatic ECAC is needed to assess whether patients will have improvement in symptoms and thus identify patients who will benefit from surgical central airway stabilization. A multidisciplinary airway team in highly specialized centers with experience in the evaluation and treatment of this patient population is essential for optimal outcomes.

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Patch tracheoplasty in body tissue engineering using collagenous connective tissue membranes (biosheets)

Cited by 29 publications

References 18 publications

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Urinary bladder reconstruction using autologous collagenous connective tissue membrane “Biosheet” induced by in-body tissue architecture

Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment

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