Patch Testing with Thimerosal in a Canadian Center: An 11-Year Experience

Freiman, Anatoli; Allayali, Ahmed Zahr; Sasseville, Denis

doi:10.2310/6620.2003.6152

Cited by 11 publications

(12 citation statements)

References 21 publications

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“…Finally, despite the higher rate of thimerosal sensitization among HCWs, we encourage HCWs to be vaccinated as appropriate. As has been previously reported, allergic patch test reactions to thimerosal are rarely relevant, 5,30,31 and most individuals with a positive patch test reaction to thimerosal do not react when vaccinated to thimerosal. 32 …”

Section: Discussionmentioning

confidence: 76%

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Kadivar

Belsito

2015

Dermatitis

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Section: Discussionmentioning

confidence: 76%

Occupational Dermatitis in Health Care Workers Evaluated for Suspected Allergic Contact Dermatitis

Kadivar

Belsito

2015

Dermatitis

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“…In the remaining patients, thimerosal sensitivity could have been induced by immunizations. Although in previous studies, high rates of thimerosal sensitivity was detected, making thimerosal one of the most common sensitizers, clinical relevance could not be shown in most of the patients and the real nature of positive reactions to thimerosal is still unknown (6, 7, 10–12). In our study, we could not find clinical relevance in any of the patients.…”

Section: Discussionmentioning

confidence: 99%

“…Thimerosal is used as a preservative in some cosmetics, ophthalmologic and otic preparations, contact lens solutions, vaccines, anti-toxins, desensitization solutions and intradermal tests. Several studies have revealed a high rate of thimerosal sensitivity in the range of 1.6%-15.3% (4)(5)(6)(7)(8)(9). Due to the decreasing use of this preservative in cosmetics and topical medications, thimerosal sensitivity is thought to be mainly induced by thimerosal containing vaccines (7,10,11).…”

Section: Discussionmentioning

confidence: 99%

Contact sensitivity to preservatives in Turkey

2005

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This study was designed to evaluate the frequency of contact sensitivity to 14 common preservatives among patients with contact dermatitis in Turkey. From 2000 to 2004, 308 patients with the diagnosis of contact dermatitis were patch tested in the Department of Dermatology, Ankara University School of Medicine. All patients were patch tested with European standard series. In addition to the four preservatives included in the standard series, patients were also tested with DMDM hydantoin, imidazolidinyl urea, bromonitropropane diol, diazolidinyl urea, thimerosal, propylene glycol, chlorocresol, chloroxylenol, methyldibromoglutaronitrile/phenoxyethanol (MDBGN/PE) and benzalkonium chloride. Out of the 308 patients suspected of having contact dermatitis, 23 patients were found to have positive reactions to one or more preservatives. Preservatives that were the most frequent cause of positive reactions were thimerosal (1.6%), benzalkonium chloride (1.6%), formaldehyde (1.3%) and MDBGN/PE (0.9%). In our study, 65% of the positive reactions were caused by allergens not present in the standard series, such as thimerosal, benzalkonium chloride and MDBGN/PE. Although thimerosal caused a high rate of contact sensitivity, it may not be considered as an important allergen, because clinical relevance could not be found in any of the patients.

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“…Because of this regular lack of identified relevant sources, the majority of US-based patch test experts have removed thimerosal from their standard screening trays. 88,89 Fragrances Fragrances are aromatic compounds that impart a smell or odor. They can be natural (from botanic or animal products) or synthetic in origin.…”

Section: Thimerosalmentioning

confidence: 99%