Patch testing with the “sesquiterpene lactone mix”: a marker for contact allergy to Compositae and other sesquiterpene‐lactone‐containing plants <i>A multicentre study of the EECDRG</i>

Ducombs, G.; Benezra, Claude; Talaga, Patrice; Andersen, Knud Erik; Burrows, D.; Camarasa, J. G.; Dooms‐Goossens, A.; Frosch, Peter J.; Lachapelle, Jean‐Marie; Menné, Torkil; Rycroft, R. J. G.; White, Ian R.; Shaw, S.; Wilkinson, J. D.

doi:10.1111/j.1600-0536.1990.tb01590.x

Cited by 96 publications

(69 citation statements)

References 11 publications

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“…SL-mix. In agreement with the fmdings in the Danish investigation, the prevalence of positive reactions was thus of the same order of magnitude as that of some of the allergens included in the standard series (12).…”

Section: Frequencysupporting

confidence: 72%

“…However, a recently developed SL-mix containing alantolactone, dehydrocostus lactone and costunolide (0.1% pet.) seems non-sensitizing, but it is not yet commercially available and, moreover, not all patients with Campositae allergy have positive reactions when tested with it (12). It is therefore advisable to attempt to isolate other SLs from the most frequently sensitizing Compositae plants, with the object of finding safe and reliable allergen concentrations for test materials.…”

Section: Resultsmentioning

confidence: 99%

“…0.1% pet. was found to be nonsensitizing and seldom irritant (12). Current investigations have shown that a number of false negative reactions occur, both on testing using this mixture of pure SLs, as well as with a mix of plant extracts.…”

Section: Allergens and Diagnosismentioning

confidence: 99%

“…Other clinical forms of Compositae dermatitis are localized face and/ or hand eczema, as well as contact urticaria, which is often seen in patients who are sensitive to lettuce (11,12).…”

Section: Clinical Aspectsmentioning

confidence: 99%

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Compositae dermatitis: a survey

Paulsen

1992

Contact Dermatitis

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Compositae dermatitis in an allergic contact dermatitis, frequently chronic, triggered by plants of the Compositae family. The condition, which is seen, in particular, in middle-aged and elderly persons, typically starts in the summer months with an acute eczema either corresponding to areas exposed to light and air, or corresponding to areas of plant contact; it disappears spontaneously during the fall of the year. Repeated exposure over a number of years may cause severe intractable dermatitis affecting the patient throughout the year. The responsible allergens are sesquiterpene lactones, and investigations to date indicate that the frequency of the allergy is similar to that seen with some of the contact allergens of the standard patch test series. The diagnosis, however, is difficult, partly due to the fact that the clinical picture may be mistaken for a photodermatosis, and partly owing to the difficulty in obtaining commercially available allergens for patch testing. The diagnosis is therefore based on testing with plant extracts, which can cause pronounced local reactions and possibly active sensitization. A survey is given of the possible modes of sensitization, sex and age distribution, the relationship to photosensitivity and atopy, as well as the possible treatment. It is conclude~, on the basis of the chronic nature of the disease, and the diagnostic and treatment problems, that continued intensive research into the condition is urgently needed.

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Section: Frequencysupporting

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Allergens and Diagnosismentioning

confidence: 99%

“…Other clinical forms of Compositae dermatitis are localized face and/ or hand eczema, as well as contact urticaria, which is often seen in patients who are sensitive to lettuce (11,12).…”

Section: Clinical Aspectsmentioning

confidence: 99%

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Compositae dermatitis: a survey

Paulsen

1992

Contact Dermatitis

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“…All over the world, different national and international groups of patch test specialists recommend the use of a standard series, with minor variations due to differences in culture, industrialization, and use in various countries. Such series are frequently revised to adapt to changes in exposure, introduction of new allergens onto the market, and experience and information gained on irritant and sensitizing (patch test sensitization) properties, as well as alterations needed to the patch test materials themselves (14)(15)(16)(17)(18)(19). Testing with the test preparations in a standard series is said to detect 70% to 80% of all contact allergies (20)(21)(22)(23)(24)(25)(26).…”

Section: Standard Test Seriesmentioning

confidence: 99%

Thoughts on sensitizers in a standard patch test series

et al. 1999

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On behalf of the European Society of Contact DermatitisPatch testing is the predominant method of establishing contact allergy. The present patch test technique is the result of a continuous process of development and improvement since its first application in the late 19th century. The perfect patch test should give no false-positive and no false-negative reactions. The ideal patch test should also cause as few adverse reactions as possible, particularly no patch test sensitization. Even though the history and examination of a patient with suspected allergic contact dermatitis will give clues to possible sensitizers, it is not sufficient to patch test only with initially suspected sensitizers; unsuspected sensitizers used for patch testing frequently turn out to be the real cause of the dermatitis. Fortunately, a small number of substances are considered to account for the majority of delayed hypersensitivity reactions. Therefore, generally 20-25 test preparations consisting of chemically defined compounds, mixes of allergens, and natural and synthetic compounds, are grouped into a standard test series. The requirements to be fulfilled by a sensitizer in a standard patch test series are discussed in this article. A procedure of investigations is proposed before a sensitizer is included in a standard series.

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Sesquiterpenlactone [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Patch testing with the “sesquiterpene lactone mix”: a marker for contact allergy to Compositae and other sesquiterpene‐lactone‐containing plants A multicentre study of the EECDRG

Cited by 96 publications

References 11 publications

Compositae dermatitis: a survey

Compositae dermatitis: a survey

Thoughts on sensitizers in a standard patch test series

Sesquiterpenlactone [MAK Value Documentation in German language, 2006]

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