Patch Testing with a Textile Dye Mix in Two Concentrations – A Multicentre Study by the Swedish Contact Dermatitis Research Group

Abstract

contact allergy to the TDM is common and inclusion into the Swedish baseline series should be considered.

Recommendation to include a textile dye mix in the European baseline series

“…Similar results were obtained in a joint study with the same mix a few years later . In 2006, the concentration was raised to 6.6%, and this TDM has been patch tested not only in Sweden and Belgium , but also in seven dermatology departments in Sweden , and in 12 clinics in nine countries in Europe and the United States . The frequencies of TDM‐positive patients were 3.7% in the European/US study and 2.5% in the Swedish study , with overall clinical relevance of 31% and 37%, respectively.…”

“…In 2006, the concentration was raised to 6.6%, and this TDM has been patch tested not only in Sweden and Belgium , but also in seven dermatology departments in Sweden , and in 12 clinics in nine countries in Europe and the United States . The frequencies of TDM‐positive patients were 3.7% in the European/US study and 2.5% in the Swedish study , with overall clinical relevance of 31% and 37%, respectively. In the recent Swedish study encompassing seven dermatology departments from all over Sweden, a TDM at 8.0% was tested in parallel, and this mix picked up 2.8% of those allergic to this mix, in contrast to 2.5% for the 6.6% mix .…”

Patch Testing To a Textile Dye Mix by the International Contact Dermatitis Research Group

“…This was also seen in the aforementioned studies from EECDRG and from the recent Swedish study. 14,15 However, in several previous studies, D Orange 1 was the most common allergen in the patients allergic to the mix. 3,13,24 In several other studies, however, D Blue 106 and D Blue 124 have been described as common allergens, 4 and many authors of studies on contact allergy to DDs have recommended them as screening allergens for textile dye dermatitis.…”

“…13 Contact allergy to the TDM was twice as common in Leuven as in Malmö in that study. Two additional studies have been performed with this TDM 6.6%, one in Sweden 14,15 In the Swedish multicenter study, the frequency of contact allergy to the TDM 6.6% was 2.5%, whereas in the EECDRG study, it was 3.7%.…”

“…In other studies, the difference has been even smaller, and it has been suggested that D Orange 3 may perhaps be excluded from the mix in the future but this would need further studies. 15 There are many possible explanations for the considerable differences in prevalence of contact allergy to the TDM between the various centers, including simultaneous reactions to PPD and the other para-substituted amino compounds, differences in referrals of patients for patch testing and differences in clothing habits. Another explanation may be differences in evaluation of the morphology of a test reaction.…”