Patch testing for cutaneous adverse drug reactions in a paediatric population: A retrospective review

Carvalho, Joana; Coutinho, Iolanda Alen; Matos, Ana Luísa; Alves, Pedro Botelho; Ramos, Leonor; Gonçalo, Margarida

doi:10.1111/cod.14167

Cited by 3 publications

(2 citation statements)

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“…However, prick and intradermal tests could be painful and have showed different sensitivity and specificity upon age and tested drugs. Patch tests in NIDHRs have a better tolerance and have proved to be safe; however, sensitivity is lower and depends on the severity of reactions 2,3 . In some patients, in vivo tests could be even contraindicated, as in severe cutaneous reactions or anaphylaxis.…”

Section: Introductionmentioning

confidence: 99%

“…Patch tests in NIDHRs have a better tolerance and have proved to be safe; however, sensitivity is lower and depends on the severity of reactions. 2,3 In some patients, in vivo tests could be even contraindicated, as in severe cutaneous reactions or anaphylaxis. Although many authors suggest direct DPT in children as a safe and reliable procedure, 4,5 especially in mild-to-moderate reactions, it has to be remembered that DPT is a time-consuming procedure that must be performed in well-being conditions.…”

Section: Introductionmentioning

confidence: 99%

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In vitro diagnostic testing for drug allergy in children

Saretta

Tomei

Mori

et al. 2023

Pediatric Allergy Immunology

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Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic-like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. In this review, we analyze the different types of in vitro tests, focusing on those used more widely such as specific IgE and on those that are still for research settings, such as basophil activation test and lymphocyte transformation test, but that have shown some useful diagnostic potential.

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Section: Introductionmentioning

confidence: 99%